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Pathogenesis of Primary Liver Tumors Induced by Chemicals

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Therapeutic Strategies in Primary and Metastatic Liver Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 100))

Abstract

Our knowledge on the pathogenesis of primary liver tumors induced by chemicals is mainly based on investigations of experimental models, especially the rat liver treated with various carcinogens. It is evident from these studies that hepatocarcinogens may have at least four different types of target cells in the liver, namely, the hepatocytes, the bile ductular epithelia, and the sinusoidal and perisinusoidal cells (Fig. 1). All of these cell types may be specifically altered by the carcinogen and give rise to tumors or tumor-like lesions [7]. According to the similarity of the neoplastic cells to their normal counterparts, the liver tumors of the rat may be classified as neoplastic hepatic nodules (corresponding to human hepatic adenomas), hepatocellular carcinomas, cholangiofibromas, cholangiocarcinomas, benign hemangioendotheliomas, angiosarcomas, and pericytomas. Sequential cellular changes have been observed during the development of most of these tumor types. Detailed analysis of the different steps of tumorigenesis has considerably improved our understanding of the pathogenesis of primary liver tumors.

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Authors and Affiliations

  1. Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 6900, Heidelberg, Germany

    P. Bannasch & H. Zerban

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  1. P. Bannasch
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  2. H. Zerban
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  1. Chirurgische Klinik, Klinikum der Universität Heidelberg, Im Neuenheimer Feld 110, 6900, Heidelberg 1, Germany

    Christian Herfarth , Peter Schlag  & Peter Hohenberger ,  & 

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Bannasch, P., Zerban, H. (1986). Pathogenesis of Primary Liver Tumors Induced by Chemicals. In: Herfarth, C., Schlag, P., Hohenberger, P. (eds) Therapeutic Strategies in Primary and Metastatic Liver Cancer. Recent Results in Cancer Research, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82635-1_1

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  • DOI: https://doi.org/10.1007/978-3-642-82635-1_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82637-5

  • Online ISBN: 978-3-642-82635-1

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