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Treatment of Miscellaneous and Unusual Infections with Trimethoprim and Trimethoprim/Sulfonamide Combinations

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Inhibition of Folate Metabolism in Chemotherapy

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 64))

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Abstract

The broad spectrum of in vitro antimicrobial activity and frequent observations of synergy with the combination of trimethoprim and sulfamethoxazole (co-trimoxazole) have lead to its evaluation clinically in a large variety of infectious diseases. Many of these are discussed in other chapters. However, a few notable exceptions remain. The present chapter is a summary of data from studies in a variety of diseases in which the combination has been evaluated in some detail, though well-controlled clinical studies have not been reported in most cases. These include brucellosis, toxoplasmosis, nocardiosis, the “atypical” mycobacterioses, histoplasmosis, paracoccidioidomycosis, phycomycosis, and chromomycosis. A few additional examples are included because of their inherent interest, despite the paucity of available information; i.e., bubonic plaque, Q fever, Isospora belli infections, pneumonitis due to the “Pittsburgh pneumonia agent,” malakoplakia, and pediculosis capitis.

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    George H. Hitchings

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Desjardins, R.E. (1983). Treatment of Miscellaneous and Unusual Infections with Trimethoprim and Trimethoprim/Sulfonamide Combinations. In: Hitchings, G.H. (eds) Inhibition of Folate Metabolism in Chemotherapy. Handbook of Experimental Pharmacology, vol 64. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81890-5_21

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