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The Role of CD28 Costimulation in the Generation of Cytotoxic T Lymphocytes

  • Chapter
Pathways for Cytolysis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 198))

Abstract

Cell-mediated cytotoxicity is one of the most important effector functions produced during cellular immune responses. There are several types of effector cells that can mediate cellular cytotoxicity and they demonstrate distinct target cell specificity. Antigen-specific, major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes (CTLs) recognize peptide antigens bound to class I or class II MHC molecules through the CD3/T cell receptor (TCR) complex. Natural killer (NK) cells and certain T lymphocytes can lyse target cells using a mechanism that does not require recognition of MHC molecules. The membrane receptors on the effector cells and target cells that are responsible for MHC-unrestricted recognition are still unknown. In the addition to the first signal through the antigen-specific receptor, a second signal derived from adhesion or costimulatory molecules is required to activate efficient cytolytic function.

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Authors and Affiliations

  1. Department of Immunology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113, Japan

    M. Azuma

  2. Department of Human Immunology, DNAX Research Institute for Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA, 94304-1104, USA

    L. L. Lanier

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  1. M. Azuma
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  1. Basel Institute of Immunology, Grenzacherstr. 487, 4005, Basel, Switzerland

    Gillian M. Griffiths

  2. Department of Biochemistry, University of Lausanne, Ch. Boveresses 155, 1066, Epalinges/Lausanne, Switzerland

    Jürg Tschopp

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Azuma, M., Lanier, L.L. (1995). The Role of CD28 Costimulation in the Generation of Cytotoxic T Lymphocytes. In: Griffiths, G.M., Tschopp, J. (eds) Pathways for Cytolysis. Current Topics in Microbiology and Immunology, vol 198. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79414-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-79414-8_4

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