SpringerLink
Log in

Assessing Treatment of Psoriasis and Eczema by Noninvasive Methods

  • Chapter
Noninvasive Methods for the Quantification of Skin Functions

  • 127 Accesses

Abstract

The efficacy of treatments for inflammatory skin diseases such as psoriasis and eczema is currently assessed using clinical scoring systems based on a gradation of erythema, scaling, and infiltration. These clinical assessments, although easy and rapid to use, are never objective and seldom reproducible. Skin biopsies and other biological samples are very useful, but, since they are generally obtained by invasive methods, their use must remain exceptional.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

eBook
USD 9.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Braverman IM, Yen A (1977) Ultrastructure of the capillary loops in the dermal papillae of psoriasis. J Invest Dermatol 68: 53–60

    Article  PubMed  CAS  Google Scholar 

  2. Duteil L, Schalla W (1987) Evolution of cutaneous parameters during antipsoriatic therapy (PUVA): comparison according to the measuring site. Fundam Clin Pharmacol 1: 395

    Google Scholar 

  3. Klemp P (1987) Cutaneous and subcutaneous blood flow measurements in psoriasis. Dan Med Bull 34: 147–159

    PubMed  CAS  Google Scholar 

  4. Ryan T (1980) Micorcirculation in psoriasis: blood vessels, lymphatics and tissue fluid. Pharmacol Ther 10: 27–64

    Article  PubMed  CAS  Google Scholar 

  5. De Lacharriére O, Kalis B (1989) Measurement of skin microcirculation. In: Leveque JL (ed) Cutaneous investigation in health and disease. Dekker, New York, pp 385–420

    Google Scholar 

  6. Klemp P, Staberg B (1983) Cutaneous blood flow in psoriasis. J. Invest. Dermatol 81: 503–506

    Google Scholar 

  7. Klemp P, Staberg B (1985) The effects of antipsoriatic treatment on cutaneous blood flow in psoriasis measured by 133Xe washout method and laser Doppler velocimetry. J Invest Dermatol 85: 259–263

    Article  PubMed  CAS  Google Scholar 

  8. Klemp P. (1985) Regulation of local subcutaneous blood flow in patients with psoriasis and effects of antipsoriatic treatment on subcutaneous blood flow. J Invest Dermatol 85: 175–178

    Article  PubMed  CAS  Google Scholar 

  9. Nilson GE, TenlandT, Oberg A (1980) A new instrument for continuous measurement of tissue blood flow by light beating spectroscopy. IEEE Trans Biomed Engin 271: 12–19

    Google Scholar 

  10. Schalla W, Duteil L (1987) Sequence of change during resolution of psoriatic lesions. J Invest Dermatol 89: 441

    Google Scholar 

  11. Bravermann IM, Sibley J (1982) Role of the microcirculation in the treatment and pathogenesis of psoriasis. J Invest Dermatol 78: 12–17

    Article  Google Scholar 

  12. FrödinT, Skogh M, Molin L (1988) The importance of the coal tar bath in the Ingram treatment of psoriasis. Evaluation by evaporimetry and laser Doppler flowmetry. Br J Dermatol 118: 429–434

    Google Scholar 

  13. Broby-Johansen U, Kristensen JK (1989) Antipsoriatic effect of local corticosteroids — 02 cosumption and blood flow measurements compared to clinical parameters. Clin Exp Dermatol 14: 137–140

    Article  PubMed  CAS  Google Scholar 

  14. Staberg B, Klemp P (1984) Skin blood flow in psoriasis during Goeckerman or beech tar therapy. Acta Derm Venereol (Stockh) 64: 331–334

    CAS  Google Scholar 

  15. Khan A, Schall LM, Tur E, Maibach HI, Guy RH (1987) Blood flow in psoriatic skin lesions: the effect of treatment. Br J Dermatol 117: 193–201

    Article  PubMed  CAS  Google Scholar 

  16. Trevisan G, Dal Canton M (1991) Laser-Doppler evaluation of cutaneous blood flow in psoriasis. G Ital Dermatol Venereol 126: 71–74

    Google Scholar 

  17. Klemp P, Staberg B (1986) Cutaneous and subcutaneous blood flow in nonlesional skin of patients with minimal psoriatic skin manifestations. J Invest Dermatol 86: 582–584

    Article  PubMed  CAS  Google Scholar 

  18. Macdonald Hull S, Goodfield M, Wood EG, Cunliffe WG (1989) Active and inactive edges of psoriatic plaques: identification by tracing and investigation by laser Doppler flowmetry and immunocytochemical techniques. J Invest Dermatol 92: 782–785

    Article  Google Scholar 

  19. Huch R, Huch A, Lübbers DW (1981) Transcutaneous PO2. Thieme-Stratton, New York

    Google Scholar 

  20. Falstie-Jensen N, Spaun E, Brochner-Mortensen, Falstie-Jensen (1988) The influence of epidermal thickness on transcutaneous oxygen pressure measurements in normal persons. Scand. J Clin Lab Invest 48: 519–523

    Google Scholar 

  21. Franzeck UK, Bollinger A, Huch R, Huch A (1984) Transcutaneous oxygen tension and capillary morphologic characteristics and density in patients with chronic venous incom-petence. Circulation 70: 806–811

    Article  PubMed  CAS  Google Scholar 

  22. Severinghaus JW, Stafford M,Thunstrom AM (1978) Estimation of skin metabolism and blood flow with tcpO2 and tcpCO2 electrodes by cuff occlusion of the circulation. Acta Anaesthesiol Scand Suppl 68: 9–15

    CAS  Google Scholar 

  23. Rooth G, Ewald U, Caligara F (1987) Transcutaneous PO2 and PCO2 monitoring at 37°C; cutaneous PO2 and PCO2. Adv Exp Med Biol 220: 23–32

    PubMed  CAS  Google Scholar 

  24. Tronnier H, Böttger EM, Hoffmann E (1979) Transcutane PO2-Messung unter UV-Therapie von Psoriasis und Akne ( Vorläufige Mitteilung ). Z Hautkr 54: 546–550

    Google Scholar 

  25. Ott A, Stüttgen G (1984) Microcirculation in psoriasis. Acta Derm. Venereol Suppl Stockh 113: 99–102

    Google Scholar 

  26. Klemp P, Bojsen J (1986) Local variation in cutaneous and subcutaneous blood flow measured by CdTe(Cl) minidetectors in normal and psoriatic skin. J Invest Dermatol 86: 109–114

    Article  PubMed  CAS  Google Scholar 

  27. Pinnagoda J, Tupker RA, AgnerT, Serup J (1990) Guidelines for transepidermal water loss ( TEWL) measurement. Contact Dermatitis 22: 164–178

    Google Scholar 

  28. Wilson DR, Maibach H (1989) Transepidermal water loss: a review. In: Lévèque JL (ed) Dekker, New York, pp 113–134

    Google Scholar 

  29. Tagami H (1989) Impedance measurement for evaluation of the hydration state of the skin surface. In: Lévèque JL (ed) Dekker, New York, pp 79–112

    Google Scholar 

  30. Tagami H, Yoshikuni K (1985) Interrelationship between water-barrier and reservoir functions of parhologic stratum corneum. Arch Dermatol 121: 642–645

    Article  PubMed  CAS  Google Scholar 

  31. Serup J, Blichmann C (1987) Epidermal hydration of psoriasis plaques and the relation to scaling. Acta Derm. Venereol (Stockh) 67: 357–366

    Google Scholar 

  32. Berardesca E, Fideli D, Borroni G, Rabbiosi G, Maibach H (1990) In vivo hydration and water retention capacity of stratum corneum in clinically uninvolved skin in atopic and psoriatic patients. Acta Derm Venereol (Stockh) 70: 400–404

    CAS  Google Scholar 

  33. Marks J, Rogers S, Chadkirk B, Shuster S (1981) Clearance of chronic plaque psoriasis by anthralin- subjective and objective assessment and comparison with photochemotherapy. Br J. Dermatol 105 S 20: 96–99

    Article  Google Scholar 

  34. Hartop PJ, Allenby CF, Prottey C (1978) Comparison of barrier function and lipids in psoriasis and essential fatty acid-deficiency rats. Clin Exp Dermatol 3: 259–267

    Article  PubMed  CAS  Google Scholar 

  35. Clar EJ, Cambrai M, Heid E, Grosshand E (1976) Electrophysiology of the epidermis in psoriasis (preliminary study). Ann. Dermatol Syph 103 /3: 291–295

    CAS  Google Scholar 

  36. Borroni G, Berardesca E, Gabba P, Rabbiosi G (1988) Skin impedance in psoraitic epidermis. Bioeng. Skin 4: 15–22

    Google Scholar 

  37. Borroni G, Berardesca E, Gabba P, Vignoli GP, Rabbiosi G (1987) Can the use of powerful topical corticosteroids at high concentrations be justified in psoriasis? An in vivo electro-physiological study. Pharmacol Skin 1: 261–264

    Google Scholar 

  38. Cambrai M, Clar EJ, Grosshans E, Altermatt C (1979) Skin impedance ans phoreographic index in psoriasis. Arch Dermatol Res 264: 197–211

    Article  PubMed  CAS  Google Scholar 

  39. Alexander H, Miller D (1979) Dertermining skin thickness with pulsed ultrasound. J Invest Dermatol 72: 17–19

    Article  PubMed  CAS  Google Scholar 

  40. Payne P (1989) Skin thickness measurement and cross sectional imaging. In: Leveque JL (ed) Dekker, New York, pp 183–214

    Google Scholar 

  41. Serup J (1984) Non-invasive quantification of psoriasis plaques-measurements of skin thickness with 15 MHz pulsed ultrasounds. Clin. Exp. Dermatol 9: 502–508

    Article  PubMed  CAS  Google Scholar 

  42. Broby-Johansen U, Karlsmark T, Petersen LJ, Serup J (1990) Ranking of the antipsoriatic effect of various topical corticosteroids applied under a hydrocolloid dressing-skin-thickness, blood flow and colour measurements compared to clinical assessments. Clin Exp Dermatol 15: 343–348

    Article  PubMed  CAS  Google Scholar 

  43. Vaillant L, Berson M, Machet L, Bertram A, Pourcelot L, Lorette G (1991) Ultrasound imaging of psoriatic skin: a non invasive technique to evaluate treatments of psoriasis. Proceedings of the 2nd International congress on ultrasound and the skin, Modena ( Italy ), Sept 1991, p 14

    Google Scholar 

  44. Boroni G, Vignati G, Zaccone C, Vignoli GP, Zanetta R, Beradesca E, Brazzelli V, Perinti A, Rabbiosi G (1991) Monitoring of psoriatic plaque during photochemotherapy by 20 MHz- Sonography. Proceeding of the 2nd international congress on ultrasound and the skin, Modena ( Italy ), Sept 1991 p 15

    Google Scholar 

  45. Grice K, Sattar H, Baker H, Sharrat M (1975) The relationship of transepidermal water loss to skin temperature in psoriasis and eczema. J Invest Dermatol 64: 313–315

    Article  PubMed  CAS  Google Scholar 

  46. Abe T, Ohkido M, Yamamoto K (1987) Studies on the skin barrier function: skin surface lipids and transepidermal water loss in atopic skin during childhood. J Dermatol 5: 223–229

    Google Scholar 

  47. Rajka G (1974) Trnsepidermal water loss on the hands in atopic dermatitis. Arch Dermatol Frosch 251: 111–115

    CAS  Google Scholar 

  48. Tagami H, Kanamaru Y, Inoue K, Suehisa S, Inoue F, Iwatsuki K, Yoshikuni K, Yamada M (1982) Water Sorption-desorption test of the skin in vivo for functional assessment of the stratum corneum. J Invest Dermatol 78: 425–428

    Article  PubMed  CAS  Google Scholar 

  49. Thune P (1989) Evaluation of the hydration and the water-holding capacity in atopic skin and so-called dry skin. Acta Derm Venereol (Stockh) S 144: 133–135

    CAS  Google Scholar 

  50. Werner Y, Lindberg M (1985) Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm Venereol (Stockh) 65: 102–105

    CAS  Google Scholar 

  51. Lodén M, Olsson H, AxellT, Werner Linde Y (1992) Friction, capacitance and transepidermal water loss ( TEWL) in dry atopic and normal skin. Br J Dermatol 126: 137–141

    Google Scholar 

  52. Watanabe M, Tagami H, Horii I, Takahashi M, Kligman A (1991) Functional analyses of the superficial stratum corneum in atopic xerosis. Arch Dermatol 127: 1689–1692

    Article  PubMed  CAS  Google Scholar 

  53. Tupker RA, Pinnagoda J, Coenraads PJ, Nater JP (1990) Susceptibility to irritants: role of barrier function, skin dryness and history of atopic dermatitis. Br J Dermatol 123: 199–205

    Article  PubMed  CAS  Google Scholar 

  54. GöllHausen R, Göttersberg K, Winter H, Przybilla B, RuzickaT, Ring J (1988) Skin sensitivity in patients with atopic eczema and normals. Evaluation by visual assessment, evaporimeter and laser Doppler flowmeter. J Invest Dermatol 90: 241

    Google Scholar 

  55. Staberg B, Klemp P, Serup J (1984) Patch test response evaluated by cutaneous blood flow measurements. Arch Dermatol 120: 741 - 743

    Article  PubMed  CAS  Google Scholar 

  56. Prens EP, Van Joost, Steketee J (1987) Quantification of patch test reactions by ranscutaneous PO2 measurement. Contact Dermatitis 16: 142–146

    Article  PubMed  CAS  Google Scholar 

  57. Serup J, Staberg B, Klemp P (1984) Quantification of cutaneous oedema in patch test reac 240 L. Duteil et al., Assessing Treatment of Psoriasis and Eczemations by measurements of skin thickness with high frequency pulsed ultrasound. Contact Dermatitis 10: 88–93

    Article  PubMed  CAS  Google Scholar 

  58. Seidenari S, Di Nardo A, Pepe P, Giannetti A (1991) Ultrasound B scanning with image analysis for assessment of allergic patch test reactions. Contact Dermatitis 24: 216–222

    Article  PubMed  CAS  Google Scholar 

  59. Seidenari S, Di Nardo A (1991) Echographic evaluation of the acitvity of topical corticosteroids Proceedings of the 2nd international congress on ultrasound and the skin, Modena (Italy) Sep 1991, p 50

    Google Scholar 

  60. Queille Roussel C, Duteil L, Padilla JM, Poncet M, Czernielewski J (1990) Objective assessment of topical anti-inflammatory drug acitivity on experimentally induced nickel contact dermatitis: comparison between visual scoring, colorimetry, laser Doppler velocimetry and transepidermal water loss. Skin Pharmacol 3: 248–255

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre International de Recherches Dermatologiques Galderma (cird Galderma), 635 Route des lucioles, Sophia Antipolis, 06565, Valbonne Cedex, France

    J. Czernielewski

Authors
  1. L. Duteil
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Queille-Roussel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Czernielewski
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hautklinik der Städtischen Kliniken Dortmund Lehrstuhl Dermatologie, Universität Witten/Herdecke, Beurhausstr. 40, 4600, Dortmund 1, Germany

    Peter J. Frosch

  2. Department of Dermatology, University of Pennsylvania School of Medicine, 19104-6142, Philadelphia, PA, USA

    Albert M. Kligman M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Duteil, L., Queille-Roussel, C., Czernielewski, J. (1993). Assessing Treatment of Psoriasis and Eczema by Noninvasive Methods. In: Frosch, P.J., Kligman, A.M. (eds) Noninvasive Methods for the Quantification of Skin Functions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78157-5_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78157-5_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78159-9

  • Online ISBN: 978-3-642-78157-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation