Abstract
Chronic ethanol poisoning is probably the commonest chemical intoxication in the world and yet one of the least understood. It can also be one of the most difficult diseases to diagnose in clinical practice. Much indirect evidence based on cell, tissue and animal studies suggests — and has done so for many years — that it is associated with increased, or at least altered, free radical activity. In humans, unfortunately, the evidence is much more sparse and far more difficult to interpret.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Albano E, Tomasi A, Goria-Gatti L, Poli G, Dianzani MU (1988) Spin trap** of ethanol derived free radicals in rat liver microsomes. In: Nordmann R, Ribière C, Rouache H (eds) Alcohol toxicity and free radical mechanisms. Pergamon, Oxford, pp 17–23
Carini R, Mazzanti R, Biasi F, Chiarpotto E, Marmo G, Moscarella S, Gentilini P, Dianzani MU, Poli G (1988) Fluorescent aldehyde-protein adducts in the blod serum of healthy alcoholics. In: Nordmann R, Ribière C, Rouache H (eds)Alcohol toxicity and free radical mechanisms. Pergamon Oxford, pp 61–69
Cawood P,Wickens DG, Iversen SA, Braganza JH, Dormandy TL (1984) The nature of diene conjugation in human serum. FEBS Lett 171: 320–324
Dormandy TL (1986) Free radicals in medicine. In: Triger DR (ed) Advanced medicine. Bailliere Tindall, London, pp 333–340
Dormandy TL (1988) Diene conjugation in chronic alcoholics. In: Nordmann R, Ribière C, Rouache H (eds) Alcohol toxicity and free radical mechanisms. Pergamon, Oxford, pp 55–60
Ekstrom G, von Bahr C, Ingelman-Sundberg K (1988) Ethanol-inducible cytochrome P-450 from human liver. In: Nordmann R, Ribière C, Rouache H (eds) Alcohol toxicity and free radical mechanisms, Pergamon. Oxford, pp 219–224
Fairbank J, Ridgway L, Griffin J, Wickens DG, Singer A, Dormandy TL (1988) Diagnosis of cervical neoplasia by the estimation of octadeca-9,11-dienoic acid. Lancet i: 537–539
Fink R, Clemens MR, Marjot DH, Iversen SA, Cawood P, Dormandy TL (1985) Increased free-radical activity in alcoholics. Lancet ii: 291–294
Hind CKR, Griffin J, Pack S, Latchman YE, Drake HF, Jones HM, Brostoff J, Dormandy TL, Treasure T (1988) The effect of cardiopulmonary bypass on circulating levels of free-radical products.Cardiovasc Res 22: 37–44
Iversen SA, Cawood P, Dormandy TL (1985) A method for the estimation of a diene-conjugated derivative of linoleic acid in serum phospholipids and its possible origin. Ann Clin Biochem 22: 137–140
Lewis K, Paton A (1982) Could superoxide cause cirrhosis? Lancet ii: 188–189
Lieber CS (1984) Alcohol and the liver. Hepatol Update 4: 1243–1260
Martin F,Ward K, Slavin G, Levi J, Peters TJ (1985) Alcoholic skeletal myopathy. Q J Med 55: 231–251
Schellenberg F, Weill J (1987) Desialotransferrin measured by isoelectric focusing. Ann Biol Chem 45: 290–295
Shaw S, Jayatilleke R, Ross WA, Gordon ER, Lieber CS (1981) Ethanol induced lipid peroxidation. J Lab Clin Med 98: 417–425
Situnayake RD, Crump BJ, Thurnham DI, Davies JA, Gearty J, Davis MN (1990) Lipid peroxidation and hepatic antioxidants in alcoholic liver disease. Gut 31: 1311–1317
Thurmann RG, Ley HC, Scholz R (1972) Hepatic microsomal ethanol oxidation. Eur J Biochem 25: 220–230
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Dormandy, T.L. (1992). Free Radical Activity in Chronic Ethanol Intoxication in Humans. In: Packer, L., Prilipko, L., Christen, Y. (eds) Free Radicals in the Brain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77609-0_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-77609-0_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-77611-3
Online ISBN: 978-3-642-77609-0
eBook Packages: Springer Book Archive