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Chorionic Villi Analysis

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Advances in Mutagenesis Research

Part of the book series: Advances in Mutagenesis Research ((MUTAGENESIS,volume 4))

Abstract

Since the mid-1980s, chorionic villi sampling in the first trimenon of pregnancy (CVS I) has gained increasing acceptance for prenatal diagnosis of fetal genetic diseases. The tissue sampling is performed in the 10th to 12th week of gestation, thus the application of this method yields earlier results than other routine techniques, e.g. amniocentesis (AC) or fetal blood sampling (FBS). This major advantage allows termination of affected pregnancies, if requested, at a time when it is both safer and less distressing. Not surprisingly, for this reason, and due to the improvements in gynecological procedures and the advent of new genetic techniques, more and more women prefer CVS I. The high acceptance of this technique can be well demonstrated by the increasing number of laboratories joining the International CVS Registry (Fig. la). This registry, maintained since 1984 through the efforts of Jackson and supported by the WHO, contains, in nearly 80000 entries, data of 193 centres in over 20 countries (Jackson 1991). It should be pointed out that this represents a highly conservative estimate of the number of the groups actually involved in CVS, since only a fraction of eligible laboratories participated in this study.

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  1. Institut für Humangenetik, Heubnerweg 6, D-1000, Berlin 19, Germany

    R. D. Wegner

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  1. FB9 der Universität Gesamthochschule Essen, Universitätsstraße 5, Postfach 10 37 64, 4300, Essen 1, Germany

    Günter Obe

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Wegner, R.D. (1993). Chorionic Villi Analysis. In: Obe, G. (eds) Advances in Mutagenesis Research. Advances in Mutagenesis Research, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77466-9_10

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