Abstract
Patient presensitization represents a considerable problem in candidacy for renal transplantation. While it is well known that hyperimmunized patients-panel reactive antibody (PRA) higher than 60% — create difficulties in donor matching and have a worse outcome than non-hyperimmunized patients, less information is available on patients with an intermediate degree of sensitization (30–60%). In order to evaluate how graft outcome relates to such degrees of sensitization, 241 consecutive transplanted patients were divided into two groups on the basis of their previous year’s PRA peak: group A, PRA 0–29%; group B, PRA 30–60%. Group A showed a significantly better survival both in the first year (90% vs 79%, P<0.05) and in the third year (82% vs 64%, P < 0.01). However, detailed analysis of group B demonstrated that some parameters may significantly influence graft outcome: (1) better compatibility on locus DR; (2) a primary kidney transplant; (3) a dialysis duration of less than 6 months; and (4) the prophylactic use of anti-lymphocyte globulin (ALG).
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© 1992 Springer-Verlag Berlin Heidelberg
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Buscaroli, A. et al. (1992). Value of panel reactive antibodies (PRA) as a guide to the treatment of hyperimmunized patients in renal transplantation. In: Kootstra, G., Opelz, G., Buurman, W.A., van Hooff, J.P., MacMaster, P., Wallwork, J. (eds) Transplant International Official Journal of the European Society for Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77423-2_17
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DOI: https://doi.org/10.1007/978-3-642-77423-2_17
Publisher Name: Springer, Berlin, Heidelberg
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