Abstract
Our previous studies showed that a broadly reactive immunoglobulin G (IgG) anti-immunoglobulin (IgG-anti-Ig) autoantibody is induced during the immune response of LEW rats to BN blood cells. The present experiments analyze the immunoregulatory effect of this physiological autoantibody on antigen receptor-activated B cells in cell cultures. The results show that: (a) At 0.9 pg IgG-anti-Ig/106 B cells, an almost complete suppression of the antibody response is induced; we calculated that a few IgG-anti-Ig molecules are sufficient to suppress the antibody response of one B cell; (b) IgG-anti-Ig-induced B-cell suppression is dose-dependent; (c) IgG-anti-Ig suppresses B cells contained in their natural environment (mixed spleen cell population). These data demonstrate that the IgG-anti-Ig autoantibody is an extremely efficient regulatory molecule of the alloimmune response.
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© 1992 Springer-Verlag Berlin Heidelberg
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Terness, P., Süsal, C., Baur, C., Opelz, G. (1992). An immunoglobulin-specific autoantibody occurring during alloimmunization suppresses the antibody response. In: Kootstra, G., Opelz, G., Buurman, W.A., van Hooff, J.P., MacMaster, P., Wallwork, J. (eds) Transplant International Official Journal of the European Society for Organ Transplantation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77423-2_164
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DOI: https://doi.org/10.1007/978-3-642-77423-2_164
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