Overview
Disruption of the major pancreatic duct or its tributaries may result in extravasation of pancreatic juice from the portion of the pancreas proximal to the obstruction. This juice may be locally contained and after 4–5 weeks develop a wall sufficiently thick to be called a pseudocyst. Less frequently, the pancreatic juice may not be contained by surrounding viscera and enter the abdominal cavity forming pancreatic ascites [1, 2]. Sometimes the juice may fistulize retroperitoneally into the pleural space [3], bronchus [4, 5], pericardium [3], colon [6, 7], portal vein [8], common bile duct [9], etc. The disruption of the pancreatic duct may be partial or complete and present from the anterior or posterior surface of the pancreas. In the case of necrotizing pancreatitis, large segments of the major pancreatic duct may be destroyed along with the surrounding parenchyma. In some instances of partial disruption of the major or tributary duct, obstruction of the major pancreatic duct proximal to the obstruction may be present which impedes flow to the duodenum and contributes to the persistence of the fistula.
Pancreatic fistulas may result from blunt or penetrating trauma, acute pancreatitis, operative trauma, pseudocysts, pancreatic necrosis, chronic pancreatitis, or carcinoma. The fistulas may be external or internal.
Pancreatic fluid collections may occur following an injury to the pancreaticductal system as a result of an operation, trauma, necrotizing pancreatitis, or infected pancreatic necrosis. Drainage of the pancreatic fluid collection externally may create a fistula. External pancreatic fistulas are usually considered low output if less than 200 ml/day and high output if over that amount [10]. Internal fistulas and ascites most often arise in the setting of chronic pancreatitis, cancer of the pancreas, or processes eroding into the pancreas, such as peptic ulcers or cancer.
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References
Cameron JL, Anderson RP, Zuidema GD (1967) Pancreatic ascites. Surg Gynecol Obstet 125:328
Donowitz M, Kerstein MI, Spiro HM (1974) Pancreatic ascites. Medicine 53:183
Pottmeyer EW, Frey CT, Matsuno S (1987) Pancreaticopleural fistulas. Arch Surg 122:648
Gouin PR, McMahon SM (1989) Transient expectoration of pancreatic fluids in a patient with pancreaticopleural fistulas. Crit Care Med 17:293
Iglehart JD, Mansback C, Postlethwaite R, Roberts L, Ruth W (1986) Pancreaticobronchial fistula. Gastroenterology 90:759
Grodinsky C, Ponka JL (1978) The spectrum of colonic involvement in pancreatitis. Dis Colon Rectum 21:66
Berne TV, Edmondson HA (1966) Colonic fistulization due to pancreatitis. Am J Surg 111:359
Willis SM, Brewer TG (1989) Pancreatic duct-portal vein fistula. Gastroenterology 97:1025–1027
Miller BM, Traverso LW, Freeny PC (1988) Intrapancreatic communication of bile and pancreatic ducts secondary to pancreatic necrosis. Arch Surg 123:1000
Pederzoli P, Bassi C, Falconi M, Albrigo R, Vantini I, Micciolo R (1986) Conservative treatment of external pancreatic fistulas with parenteral nutrition alone or in combination with continuous intravenous infusion of somatostatin, glucagon, or calcitonin. Surg Gynecol Obstet 163:428
Kerlin DL, Frey CF, Bodai BI, Twomey PL, Ruebner B (1987) Cystic neoplasms of the pancreas. Surg Gynecol Obstet 165:475
Broughan TA, Leslie JD, Scoto JM, Hermann RE (1986) Pancreatic islet cell tumors. Surgery 99:671
Stefanini P, Carboni M, Patrassie N, Basoli A (1974) Beta islet cell tumor of the pancreas: results of a study on 1067 cases. Surgery 75:597
Modlin IM (1979) Endocrine tumors of the pancreas. Surg Gynecol Obstet 149:751
Joehl RJ, Nahrwold DL (1985) Inhibition of human pancreatic secretion by terbutaline as a potential agent for treating patients with pancreatic fistulas. Surg Gynecol Obstet 160:109
Miller BM, Traverso LW, Freeny PC, Abumrad NN (1989) Failure of somatostatin or an analog to promote closure of end pancreatic fistulae. Int J Pancreatol 4:65
Prinz RA, Pickleman J, Hoffman JP (1988) Treatment of pancreatic cutaneous fistulas with a somatostatin analog. Am J Surg 155:36
Tao LC, Ho C-S, McLoughlin MJ, McHattie J (1978) Percutaneous fine needle aspiration biopsy of the pancreas. Acta Cytol 22:215
Pellegrini CA, Heck CF, Raper S, Way LW (1989) An analysis of the reduced morbidity and mortality rates after pancreaticoduodenectomy. Arch Surg 124:778
Ihse I, Toregard BM, Akerman M (1979) Intraoperative fine needle aspiration cytology in pancreatic lesions. Ann Surg 190:732
Weiss SM, Skibber JM, Mohiuddin M, Rosato FE (1985) Rapid intraabdominal spread of pancreatic cancer. Arch Surg 120:415
Lightwood R, Reber HA, Way LW (1976) The risk and accuracy of pancreatic biopsy. Am J Surg 132:189
Moossa AR, Altorki N (1983) Pancreatic biopsy. Surg Clin North Am 63:1205
Campanale RP, Frey CF, Farias LR, Twomey PL, Guernsey JM, Keehn R, Higgins G (1985) Reliability and sensitivity of frozen section pancreatic biopsy. Arch Surg 120:283
Meinke WB, Twomey PL, Guernsey JM, Frey CF, Higgins G, Keehn R (1983) Gastric outlet obstruction following palliative surgery for cancer of the head of the pancreas. Arch Surg 118:550
Meinke WB, Twomey PL, Guernsey JM, Frey CF, Farias LR, Higgins G, Keehn R (1983) Gastrointestinal bleeding after operation of pancreatic cancer. Am J Surg 146:57
Schouten JT (1986) Operative therapy for pancreatic carcinoma. Am J Surg 151:626
Whipple AO, Parsons WB, Mullins CR (1935) Treatment of carcinoma of the ampulla of vater. Ann Surg 102:763
Dreyer BJ (1962) Pancreaticoduodenectomy with ligatures of the pancreatic duct. Arch Surg 85:465
Goldsmith HS, Ghosh BC, Huvos AG (1971) Ligation versus implantation of the pancreatic duct after pancreaticoduodenectomy. Surg Gynecol Obstet 132:87
Forrest JF, Longmire WP (1979) Carcinoma of the pancreas and periampullary region. Ann Surg 189:129
Crist DW, Sitzmann JV, Cameron JL (1987) Improved hospital morbidity, mortality and survival after the Whipple procedure. Ann Surg 206:358
LeRut JP, Gianello PR, Otte JB, Kestens PJ (1984) Pancreaticoduodenal resection. Ann Surg 199:432
O’Brien PH, Mincey KH (1985) Analysis pancreaticoduodenectomy. J Surg Oncol 28:50
Gall FP, Gebhardt C, Zirngibl H (1982) Chronic pancreatitis: results of 116 consecutive and partial duodenopancreatectomies combined with pancreatic duct occlusion. Hepatogastroenterology 29:115
Funovics JM, Zoch G, Wenz E, Schulz F (1987) Progress in reconstruction afte resection of the head of the pancreas. Surg Gynecol Obstet 164:545
Van Heerden JA (1984) Pancreatic resection for carcinomas of the pancreas: Whipple versus total pancreatectomy -an institutional perspective. World J Surg 8:880
Trede M (1985) The surgical treatment of pancreatic carcinoma. Surgery 97:28
Telford GL, Mason GR (1984) Pancreaticogastrostomy: clinical experience with a direct pancreatic duct to gastric mucosa anastomosis. Am J Surg 147:832
Lygidakis NJ, Brummelkamp WH (1985) A new approach for the reconstruction of continuity of the alimentary tract after pancreaticoduodenotomy. Surg Gynecol Obstet 160:453
Itani KM, Coleman RE, Meyers WG, Akwari OE (1986) Pylorus-preserving pancreatoduodenectomy. Ann Surg 204:655
Frey CF (1983) Subtotal pancreatectomy. In: Brooks JR (ed) Surgery of the pancreas. Saunders, Philadelphia, p 242
Warren KW, Broach JW, Ihum CW (1968) Diagnosis and surgical treatment of carcinomas of the pancreas. Curr Probl Surg 3:10
Maetani S (1972) Modified methods of pancreaticojejunal anastomosis following pancreaticoduodenectomy. Surg Gynecol Obstet 134:1003
O’Brien PH, Mincey KH (1985) Analysis of pancreatoduodenectomy. J Surg Oncol 28:50–58
Imanoga H (1966) A new method of pancreaticoduodenectomy designed to preserve liver and pancreatic function. Surgery 47:577
Greene BS, Loubeau JM, Peoples JB, Elliot DW (1990) Are pancreato-enteric anastomoses improved by duct to mucosa sutures? Presented at the annual meeting of SSAT, May 15, 1990
Phelan JT (1969) A technique of pancreaticoduodenectomy. Surg Gynecol Obstet 129:116
Fish JC, Smith LB, Williams RP (1969) Digestive function after radical pancreaticoduodenectomy. Am J Surg 117:40
Jordan GL (1970) Pancreatic fistula. Am J Surg 119:200
Monge JJ, Judd ES, Gage RP (1964) Radical pancreatoduodenectomy: a 22-year experience with complications, mortality rate and survival rate. Ann Surg 160:711
Aston SJ, Longmire WP Jr (1973) Pancreaticoduodenal resection. Arch Surg 106:813
Gilsdorf RB, Spanos P (1973) Factors influencing morbidity and mortality in pancreaticoduodenectomy. Ann Surg 177:332
Braasch JW, Deziel DJ, Rossi RL, Watkins E, Winter PF (1986) Pyloric and gastric preserving pancreatic resections. Ann Surg 204:411
Edis AJ, Kiernan PD, Taylor WF (1980) Attempted curative resection of ductal carcinoma of the pancreas: review of Mayo Clinic experience, 1951–1975. Mayo Clin Proc 55:531–536
Herter FP, Cooperman AM, Ahlborn TN, Antinori C (1982) Surgical experience with pancreatic and periampullary cancer. Ann Surg 195:274
Kairaluoma MI, Kiviniemi H, Stahlberg M (1987) Pancreatic resection for carcinoma of the pancreas and the periampullary region in patients over 70 years of age. Br J Surg 74:116
Warren KW, Choe DS, Plaza J, Relihan M (1975) Results of radical resection for periampullary cancer. Ann Surg 181:534
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Frey, C.F. (1992). Pancreatic Fistulas and Tumors of the Pancreas. In: Pederzoli, P., Bassi, C., Vesentini, S. (eds) Pancreatic Fistulas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77418-8_6
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DOI: https://doi.org/10.1007/978-3-642-77418-8_6
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