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Genetic Control of the Susceptibility to Infection with Pathogenic Bacteria

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Genetic Control of the Susceptibility to Bacterial Infection

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 124))

Abstract

The elegant early work of Benacerraf and Germain (1978), McDevitt (1976), and others (Klein 1975; Snell et al. 1976) has clearly demonstrated the influence of the mouse histocompatibility complex (H-2) on the susceptibility or resistance of different strains of mice to a variety of diseases including bacterial infections. As a result, numerous investigations have resulted in a veritable explosion of knowledge concerning these interrelationships. Many aspects of these murine H-2 genetic influences on these disease associations will be described in other chapters in this book. Our task is to point out those examples in man in which there is a definite or presumed relationship of the human histocompatibility system (HLA) to disease susceptibility and pathogenesis of bacterial disease.

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Authors and Affiliations

  1. Rockefeller University, 1230 York Avenue, New York, NY, 10021-6399, USA

    J. B. Zabriskie

  2. Cornell University Medical College, New York, USA

    A. Gibofsky

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  1. J. B. Zabriskie
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  2. A. Gibofsky
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Editors and Affiliations

  1. Department of Microbiology and Pediatrics, Cellular Immunobiology Unit of the Tumor Institute, USA

    David E. Briles Ph.D.

  2. Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, 35294, USA

    David E. Briles Ph.D.

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© 1986 Springer-Verlag Berlin · Heidelberg

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Zabriskie, J.B., Gibofsky, A. (1986). Genetic Control of the Susceptibility to Infection with Pathogenic Bacteria. In: Briles, D.E. (eds) Genetic Control of the Susceptibility to Bacterial Infection. Current Topics in Microbiology and Immunology, vol 124. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70986-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-70986-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-16238-4

  • Online ISBN: 978-3-642-70986-9

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