Abstract
Glia maturation factor (GMF), discovered in our laboratory (Lim et al. 1972, 1973; Lim and Mitsunobu 1974), is one of the first brain-derived growth factors reported (Lim 1980, 1985). These factors often have target cells within the nervous system and thus may have autoregulatory functions in brain development, repair and regeneration. GMF is an acidic protein extractable at neutral pH from the mature brain of various species. In addition to promoting the proliferation and differentiation of astrocytes, GMF is also a mitogen for Schwann cells. GMF stimulates astrocytes to produced second order hormones such as interleukin-1 and prostaglandins. When added to cultures of glial tumor cells, GMF partially reverses the malignant process by promoting contact inhibition. The isolation of this biologically active protein is essential to the understanding of its mechanism of action.
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Lim R, Mitsunobu K, Li WKP (1973) Maturation-stimulating effect of brain extract and dibutyryl cyclic AMP on dissociated embryonic brain cells in culture. Exp Cell Res 79: 243–246
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© 1986 Springer-Verlag Berlin Heidelberg
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Lim, R., Miller, J.F. (1986). Isolation of Glia Maturation Factor with HPLC and Verification with a Monoclonal Antibody. In: Montalcini, R.L., Calissano, P., Kandel, E.R., Maggi, A. (eds) Molecular Aspects of Neurobiology. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70690-5_9
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DOI: https://doi.org/10.1007/978-3-642-70690-5_9
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