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Frequency and Origin of Chromosome Abnormalities in Man

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Mutations in Man

Abstract

During the past 25 years human cytogenetics has changed from a highly specialized academic discipline restricted to only a few institutions to a rapidly expanding area of research and routine application involving hundreds of laboratories. World-wide several millions of individuals have now been karyotyped, perhaps more than from any other species. This immense progress was based on at least three important methodological developments:

  1. 1.

    the introduction of the lymphocyte culture technique as an easily accessible source of mitotic cells (Nowell 1960),

  2. 2.

    the improvement in preparing metaphase spreads by combination of the hypotonic solution pretreatment (Hsu 1952), and the air-drying technique (Rothfels and Siminovitch 1958), and

  3. 3.

    the development of various differential staining techniques which allowed the identification of each chromosome pair and the accurate delineation of structural rearrangements (see Schwarzacher 1976; Comings 1978; Schweizer 1981 for re-view).

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Authors and Affiliations

  1. Institut für Humangenetik, FU Berlin, Heubnerweg 6, 1000, Berlin 19, Germany

    K. Sperling

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  1. K. Sperling
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Editors and Affiliations

  1. Institut für Genetik, Freie Universität Berlin, Arnimallee 5-7, 1000, Berlin 33, Germany

    Günter Obe

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© 1984 Springer-Verlag Berlin Heidelberg

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Sperling, K. (1984). Frequency and Origin of Chromosome Abnormalities in Man. In: Obe, G. (eds) Mutations in Man. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69530-8_6

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  • DOI: https://doi.org/10.1007/978-3-642-69530-8_6

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  • Print ISBN: 978-3-642-69532-2

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