Abstract
The diagnostic potential of visualization of lymphatic vessels and lymph nodes was recognized soon after the discovery of X-rays. A variety of heavy metal salts, sodium or potassium iodides, and bromides were injected intralymphatically into cavities as well as into soft tissues. Lymphograms were produced but serious tissue damage resulted [1,2]. In 1931, it was found that Thorotrast, a thorium-containing colloid, which at the time was believed to be a biologically inert substance, would, upon injection into the pleural space of animals, visualize the thoracic and diaphragmatic lymph vessels [3]. Also, the newly discovered iodized oil, Lipiodol, instilled into the maxillary sinus, successfully demonstrated lymphatic drainage of the maxillary area [4].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Capua A (1934) Iniezioni di thorotrast colloidale nella cavita peritoneale per lo studio della diffusione del mezzo di contrasto per le vie linfatiche. Radiol Med (Torino) 21:289–294
Dotti E (1934) Erforschung der Funktion der Lymphgefäße und Lymphdrüsen mittels Röntgendarstellung nach subkutaner Injektion von Thoriumdioxyd (Tierexperimente). Fortschr Geb Roentgenstr 50:615–618
Menville LJ, Ané JN (1934) A roentgen study of the absorption by the lymphatics of the thorax and diaphragm of thorium dioxide injected intrapleurally into animals. AJR 31:166–172
Pfahler GE (1932) A demonstration of the lymphatic drainage from the maxillary sinuses. AJR 27:352–356
Kinmonth JB (1972) The lymphatics; diseases, lymphography and surgery. Arnold, London
Schaffer B, Koehler PR, Daniel CR, Wohl GT, Riveria E, Meyers WA et al. (1963) A critical evaluation of lymphangiography. Radiology 80:917–936
Desmons M, Ramioul H (1964) Essaimage néoplastique périlymphatique après lymphographie dans un cas de tumeur mélanique du pied. J Radiol Electrol 45:703–705
Koehler PR (1967) Lymphography. Complications and accidents. In: Ruttimann A (ed) Progress in lymphology. Thieme, Stuttgart, pp 306–307
Juillard GJF, Boyer PJJ (1977) Intralymphatic immunization: current status. Eur J Cancer 13:439–440
Edwards JM (1972) Endolymphatic radiotherapy. In: Kinmonth JB (ed) The lymphatics. Arnold, London, pp 364–389
Kiusk H (1971) Technique of lymphography and principles of interpretation. Green, St. Louis, pp 284–307
Averette HE, Viamonte MI, Fergusson JH (1963) Lymphangiodenography as a guide to lymphadenectomy. Obstet Gynecol 21:682–686
Jackson RJA (1970) Chlorophyllated lipiodol ultrafluid as a contrast medium: an explanation for the disadvantages attending its use. In: Viamonte M, Koehler PR, Witte M, Witte C (eds) Progress in lymphography. Thieme, Stuttgart, pp 179–183
Fischer HW (1977) Introduction to angiographic contrast agents. In: Miller RE, Skucas J (eds) Radiographic contrast agents. University Park Press, Baltimore, p 465
Doss LL, Alyea JL, Waggoner CM, Schroeder TT (1980) Fluorescein-aided isolation of lymphatic vessels for lymphangiography. AJR 134:603–604
Fischer HW (1962) Intralymphatic introduction of radioactive colloids into the lymph nodes. Radiology 79:297–301
Heinzel F, Rosier M (1966) Quantitative investigation of the dynamics of intralym-phatically applied substances. In: Ruttimann A (ed) Progress in lymphology. Thieme, Stuttgart, pp 248–253
Heinzel F, Rösier H, Ruttimann A, Wirth W (1968) Kinetische Untersuchungen nach intralymphatischer Applikation radioaktiver Substanzen. Radiologe 8:154–158
Fischer HW (1959) Lymphangiography and lymphadenography with various contrast agents. Ann NY Acad Sci 78:799–808
Tjernberg B (1956) Lymphography as an aid to examination of lymph nodes; preliminary report. Acta Soc Med Ups 61:207–214
Thomas SF, Dummel RJ, Patterson JA, Madden JD, Dummel GM (1959) Uniform colloidal dispersion for hepatolienography. Ann NY Acad Sci 78:793–798
Fuchs WA (1965) Lymphographie und Tumordiagnostik. Springer, Berlin Heidelberg New York
Jonsson K, Anderson JH, Osborne B, Wallace S (1977) Ether-dissolved ethiodol for lymphangiography: an experimental study. AJR 129:1047–1050
Ronneburg HP (1976) The addition of ether to contrast medium lipiodol ultrafluid — a proven modification of lymphographie examinations. Radiol Diagn (Berl) 17:523–524
Svoboda M (1971) Radiocontrast agents for lymphography. In: Knoefel PK (ed) The international encyclopedia of pharmacology and therapeutics, sect 76, pt II. Pergamon, Oxford, pp 413–429
Kiusk H (1971) Technique of lymphography and principles of interpretation. Green, St. Louis
Wendth AF, Moriarty DF, Cross UF, Vitale P (1968) Urinary bladder opacification following lymphangiography. Radiology 91:762–763
Blaudow K, Banaschak A (1968) Die Bedeutung der Lymphographie für gynäkologische Karzinome. Radiol Diagn (Berl) 9:661–668
Gerteis W (1972) Darstellungsmethoden des Lymphgefäßsystems und praktische Lymphographie. In: Von Messen H (ed) Lymphgefäß-System — Lymph vessel system. Springer, Berlin Heidelberg New York, pp 595–636 (Handbuch der allgemeinen Pathologie, vol 3/6)
Teske H-J, Kalkowski B (1977) On the persistence of an oily contrast medium (lipiodol ultrafluid®) in normal and abnormal lymph nodes. In: Mayall RC, Witte MH (eds) Plenum, New York, pp 157–161
Davidson JW (1969) Lipid embolism to the brain following lymphography: case report and experimental study. AJR 105:763–771
Koehler PR (1968) Complications of lymphography. Lymphology 1:116–120
Redman HC (1966) Dermatitis as a complication of lymphangiography. Radiology 86:323–326
Kiusk H (1971) Technique of lymphography and principles of interpretation. Green, St. Louis, pp 43–51
Bron KM, Baum S, Abrams HL (1963) Oil embolism in lymphangiography: incidence, manifestations and mechanism. Radiology 80:194–202
Clouse ME, Hallgrimsson J, Wenlund DE (1966) Complications following lymphography with particular reference to pulmonary oil embolization. AJR 96:972–978
Yoffey JM, Courtice FC (1970) Lymphatics, lymph and the lymphomyeloid complex. Academic Press, New York
Rusznyák I, Földi M, Szabó G (1967) Lymphatics and lymph circulation; physiology and pathology. Pergamon, Oxford
Kampmeier OF (1969) Evolution and comparative morphology of the lymphatic system. Thomas, Springfield
Gooneratne BWM (1974) Lymphography, clinical and experimental. Butterworth, London
Kalima TV, Collan Y, Kalima SH (1977) Variations of lymphatic endothelial cell junctions in experimental conditions. In: Mayall RC, Whitte MH (eds) Progress in lymphology. Plenum, New York, pp 7–12
Yoffey JM, Courtice FC (1970) Lymphatics, lymph and the lymphomyeloid complex. Academic, New York, pp 236–246
Rusznyák I, Földi M, Szabó G (1967) Lymphatics and lymph circulation; physiology and pathology. Pergamon, Oxford, pp 566–592
Hargens AR (ed) (1981) Tissue fluid pressure and composition. Williams and Wilkins, Baltimore
Rusznyák I, Földi M, Szabó G (1967) Lymphatics and lymph circulation; physiology and pathology. Pergamon, Oxford, pp 511–565
Málek P (1967) Pathophysiological and radiological aspects of lymphovenous anastomosis. Experientia [Suppl] 14:197–203
Yoffey JM, Courtice FC (1970) Lymphatics, lymph and the lymphomyeloid complex. Academic, New York, pp 187–189,220–222
Kinmonth JB, Taylor GW (1964) Chylous reflux. Br Med J 1:529–532
Gross F, Haefeli H (1952) Motion picture analysis of blood circulation stimulators on the blood vessels of the mesotestis of the rat. Physiol Pharmacol Acta 10:C4–6
Mislin H (1975) The functional organization of vasomotoric lymph drainage. In: Gregl A (ed) Lymphographie und Pharmakolymphographie. Fischer, Stuttgart, p 10
Hargens AR, Zweifach BW (1977) Contractile stimuli in collecting lymph vessels. Am J Physiol 233.H57–H65
Schaffer B, Koehler PR, Daniel CR, Wohl GT, Riveria E, Meyers WA, Skelley JF (1963) A critical evaluation of lymphangiography. Radiology 80:427
Chiappa S, Campani R, Felder E, Ferrari D, Tirone P (1979) Experimental lymphography by intratissue injection of a crystal suspension. In: Mólek P, Bartoš V, Weissleder H, Witte MH (eds) Lymphology. Proc of the VI international congress, Prague, 1977. Thieme, Stuttgart, pp 359–362
Vogel G (1972) Pharmacology of the lymph and the lymphatic system. In: Von Messen H (ed) Lymphgefäß-System — Lymph vessel system. Springer, Berlin Heidelberg New York, pp 363–404 (Handbuch der allgemeinen Pathologie, vol 3/6)
Vogel G (1979) Pharmacology of the lymph and the lymphatic system. In: Malek P, Bartos V, Weissleder H, Witte MH (eds) Lymphology. Proc of the VI international congress, Prague, 1977. Thieme, Stuttgart, pp 205–210
Schaffer B, Koehler PR, Daniel CR, Wohl GT, Riveria E, Meyers WA, Skelley FJ (1963) A critical evaluation of lymphangiography. Radiology 80:917–930
Kinmonth JB (1952) Lymphangiography in man. Method of outlining lymphatic trunks in man. Clin Sci 11:13–20
Mayall RC, Mayall ACDG, Mehri ET, Ferretti UR, Villani MV (1977) Lymphokinetics-lymphangiographic demonstration of lymphokinetic effect of benzo-pyrone. In: Mayall RC, Witte MH (eds) Progress in lymphology. Plenum, New York, pp 179–196
Bartos V, Kolc J, Málek P (1979) The effect of Venalot on experimental pancreatitis in dogs. In: Mâlek P, Bartos V, Weissleder H, Witte MH (eds) Lymphology. Proc of the VI international congress, Prague, 1977. Thieme, Stuttgart, pp 231–233
Mislin H (1961) Experimenteller Nachweis der autochthonen Automatic der Lymphgefäße. Experientia 17:29–30
Mislin H (1971) Effect of coumarin from Melilotus officinalis on the function of lymphangion. Arzneim Forsch 21:852–853
Kinmonth JB, Taylor GW, Harper RAK (1955) Lymphangiography by radiological methods. J Fac Radiols (Lond) 6(4):217–223
Krajnovic P (1975) Application of Venalot in lymphography. In: Gregl A (ed) Lymphographie und Pharmakolymphographie. Fischer, Stuttgart
Benda K(1977) Pharmakolymphographie. Radiol Diagn (Berl) 18:289–300
Brůna J, Sůnová J (1979) Technique and possibilities of clinical pharmacolymphography. In: Malek P, Bartos V, Weissleder H, Witte MH (eds) Lymphology. Proc of the VI international congress, Prague, 1977. Thieme, Stuttgart, pp 355–357
Rovière H, Valette G (1937) Physiologie du système lymphatique „Formation de la lymphe, circulation lymphatique normale et pathologique”. Masson, Paris
Bellinazzo P, Monteverde G (1953) Effects of the sympathetic nervous system on the circulation of the lymph in the limbs, experimental research by means of Thorotrast lymphography. Minerva Chir 8:731–740
Guerbet M, Bismuth V, Desprez-Curely JP, Gluckman A, Bourdon R (1970) Lymphangiography with new oily contrast media. In: Viamonte M, Koehler RP, Witte M (eds) Progress in lymphology II. Thieme, Stuttgart, p 181
Vogel G, Ströcker H (1967) Original differences in capillary permeability — investigations of the penetration of polyvinyl pyrrolidone and endogenous proteins from plasma in the rabbit lymph. Pfluegers Arch Gesamte Physiol 294:119–126
Clark ER, Clark EL (1936) Observations on living mammalian lymphatic capillaries: their relation to the blood vessels. Am J Anat 60:253–298
Wiedemann MP (1963) Patterns of the arteriovenous pathways. In: Handbook of physiology, sect 2 — Circulation, vol 2. American Physiol Soc, Washington DC, pp 891–933
Dennhardt R, Gartemann H (1979) Technique for the collection of intestinal lymph with an extracorporeal intestinal lymphatic-vena cava shunt. In: Malek P, Bartos V, Weissleder H, Witte MH (eds) Lymphology. Proc of the IV international congress, Prague, 1977. Thieme, Stuttgart, pp 88–91
Leeds SE, Uhley HN, Meister RB (1977) The cardiac and pulmonary efferent lymphatics. Folia Angiol 25:65
Nelson AW, Swan H (1969) Long-term catheterization of the thoracic duct in the dog. Arch Surg 98:83–86
Danese CA (1968) Regeneration of lymphatic vessels. In: Mayerson HS (ed) Lymph and the lymphatic system. Springfield, Illinois, pp 53–73
Foldi M (1968) Lymphogenous encephalography. In: Mayerson H (ed) Lymph and the lymphatic system. Springfield, Illinois, p 169
Job TT (1918) Lymphatico-venous communications in the common rat and their significance. Am J Anat 24:467–491
Takashima T, Benninghoff DL (1966) Lymphatico-venous communications and lymph reflux after thoracic duct obstruction: an experimental study in the dog. Invest Radiol 1:188–197
Witte MH, Witte Cl, Kintner K, Thomas D (1979) Effect of abdominal paracentesis on thoracic duct lymph dynamics in experimental ascites. In: Malek P, Bartos V, Weissleder H, Witte MH (eds) Lymphology. Proc of the VI international congress, Prague, 1977. Thieme, Stuttgart, pp 138–141
Burn JI (1974) Obstructive lymphopathy. In: Gooneratne BWM (ed) Lymphography, clinical and experimental. Butterworth, London, pp 34–55
Schacher JF, Sulahian A, Edeson JFB (1969) Experimental lymphoedema in dogs infected with Brugia spp. Trans R Soc Trop Med Hyg 63:682–684
Drinker CK, Field ME, Homans J (1934) The experimental production of edema and elephantiasis as a result of lymphatic obstruction. Am J Physiol 108:509–520
Gooneratne BWM (1974) Lymphography in experimental filariasis. In: Gooneratne BWM (ed) Lymphography, clinical and experimental. Butterworth, London, pp 83–122
Leeds SE, Uhley HN, Meister RB (1979) Application of direct cannulation and injection lymphangiography to the study of the canine cardiac and pulmonary efferent mediastinal lymphatics. Invest Radiol 14:70–78
Gooneratne BWM (1972) The lymphatic system of cats outlined by lymphography. Acta Anat 81:36–41
Gooneratne BWM (1974) Simian lymphography. In: Gooneratne BWM (ed) Lymphography, clinical and experimental. Butterworth, London, pp 165–176
Gooneratne BWM (1972) Lymphatic system in rhesus monkeys (Macaca mulatto) outlined by lower limb lymphography. Acta Anat 81:602–608
McCullough DL (1975) Experimental lymphangiography: experience with direct medium injection into the parenchyma of the rat testes and prostate. Invest Urol 13:211 – 219
Johansson S, Sternby NH, Theander G, Wehlin L (1966) Iodinated oil emulsion for lymphography. Acta Radiol [Diagn] 4:690–704
Vialla M, Colin R (1964) Essai comparatif entre les méthodes d’opacification lymphatique avec produits hydrosolubles et liposolubles. J Radiol Electrol 45:190–192
Fischer HW (1966) Experiences in seeking an Ethiodol emulsion for lymphography. Invest Radiol 1:29–36
Koehler PR (1965) Radiographic visualization of the substernal lymph nodes. Radiology 85:565–567
Penning L, Kerckhoffs HP (1967) Comparative experimental evaluation of several types of emulsified oily radiopaque materials in the cranial subarachnoid space. Radiology 88:730–735
Teplick JG, Haskin ME, Skelley J, Wohl GT, Sanen F (1964) Experimental studies with a new radiopaque emulsion. Radiology 82:478–485
Roth S, Hiort U, Joseph K, Jost F, Kalbfleisch H, Müller H, Vielhauer E (1979) Indirect lymphography and lymph scintigraphy of the retrosternal lymphatics with a new contrast emulsion and its isotope. In: Malek P, Bartos V, Weissleder H, Witte MH (eds) Lymphology. Proc of the VI international congress, Prague, 1977. Thieme, Stuttgart, pp 352–355
Grimes G, Vermess M, Gallelli JF, Girton M, Chatterji DC, et al. (1979) Formulation and evaluation of ethiodized oil emulsion for intravenous hepatography. J Pharm Sci 68:52–56
Siefert HM, Mützel W, Schöbel C, Weinmann H-J, Wenzel-Hora BI, Speck U (1980) Iotasul, a water-soluble contrast agent for direct and indirect lymphography. Results of preclinical investigations. Lymphology 13:150–157
Wenzel-Hora BI, Siefert HM, Grüntzig J (1982) Animal experimental studies of indirect lymphography of the eye, face and neck regions using Iotasul. Lymphology 15:32–35
Griintzig VJ, Wenzel-Hora BI, Siefert HM (1982) Die indirekte Lymphographie am Auge und im Gesichts-Hals-Bereich mit Iotasul im Tier experiment. Fortschr Röntgenstr 136:592–594
Wenzel-Hora BI, Kalbas B, Siefert HM, Arndt JO, Schlösser HW, Huth F (1981) Iotasul, a water-soluble (non-oily) contrast medium for direct and indirect lymphography. Lymphology 14:101–112
Apitzsch DE, Kroll H-U, Zühlke HV (1981) Indirect caudal lymphography using a new water-soluble contrast agent — animal experimental studies in pigs. Lymphology 14:95–100
Clark LC, Kaplan S, Becattini F (1970) The physiology of synthetic blood. J Thoracic Cardiovas Surg 60:757–773
Long DM, Liu MS, Szanto PS, Alrenga P (1972) Initial observations with a new X-ray contrast agent — radiopaque perfluorocarbon. Rev Surg 29:71–76
Liebner EJ (1977) Evaluation of perfluoroctylbromide for lymphography in the dog: comparison with Ethiodol. Invest Radiol 12:368–372
Long DM, Nielson MD, Multer FK, Lasser EC, Liu MS, Russell S (1979) Comparison of radiopaque perfluorocarbon and Ethiodol in lymphography. Radiology 133:71–76
Miller ML, Stinnett JD, Clark LC (1980) Ultrastructure of tumoricidal peritoneal exudate cells stimulated in vivo by perfluorochemical emulsions. J Reticuloendothel Soc 27:105–118
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Sovak, M. (1984). Contrast Media in Lymphography. In: Sovak, M. (eds) Radiocontrast Agents. Handbook of Experimental Pharmacology, vol 73. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69515-5_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-69515-5_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69517-9
Online ISBN: 978-3-642-69515-5
eBook Packages: Springer Book Archive