Abstract
Since the establishment of the United States Army Antimalarial Drug Development Programme in 1963, there has been a continual evolution of the organisational structure, the philosophy, the approach and the methods used. This evolution reflects the rapid development of science and technology in these years, the gradual development of a multidisciplinary cadre of scientists and the evolution of ethical principles and statutory requirements. The philosophy, approaches and methods which will be discussed in this chapter are those which have been employed by the US Army Programme in the past, those which are presently being employed and those which will be incorporated in the future. As the science and technology of drug development continue to evolve, more rational and more efficient methods must be developed and applied to malaria research, to ensure the optimal use of the limited resources which have traditionally been allocated to this disease.
The author dedicate this chapter to the late Dr. Robert S. Rozman, who devoted most of his later years to the development of antimalarial drugs.
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Heiffer, M.H., Davidson, D.E., Korte, D.W. (1984). Preclinical Testing. In: Peters, W., Richards, W.H.G. (eds) Antimalarial Drugs I. Handbook of Experimental Pharmacology, vol 68 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69251-2_12
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DOI: https://doi.org/10.1007/978-3-642-69251-2_12
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