Abstract
The use of immunohistochemical techniques has confirmed the presence of neurohypophyseal and adenohypophysiotropic hormones within axons and axon terminals of the median eminence (see ZIMMERMAN, 1976). The magnocellular perikarya of the supraoptic (SON) and paraventricular nuclei (PVN) have also been confirmed as the sources of the neurohypophyseal hormones (BURLET et al., 1974; VANDESANDE et al., 1975). However, the location of the perikarya of origin of the “releasing and inhibiting hormones” remains a source of controversy. Using antisera capable of detecting somatostatin perikarya in normal animals, and LRH perikarya in castrated rats, we have begun a study on the topical neuroanatomy of neuroendocrine cells. We have taken the approach of using the magnocellular neurons of the hypothalamo-neurohypophyseal system as regional landmarks against which to compare the distribution of perikarya containing releasing and inhibiting hormones. We have also been able to identify a substantial amount of arginine vasopressin (AVP), oxytocin (OT), and neurophysin (NPh) containing fibers in several areas of the brain outside the hypothalamus.
Supported by the Deutsche Forschungsgemeinschaft (SFB 51-C/21 and C/27).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Alpert, L.C., Brawer, J.R., Patel, Y.C., Reichlin, S.: Somatostatinergic neurons in anterior hypothalamus: immunohistochemical localization. Endocrinology 98, 255–259 (1976)
Barker, J.L.: Peptides: Roles in neuronal excitability. Physiol. Rev. 56, 435–452 (1976)
Barry, J., Dubois, M.P., Poulain, P.: LRF producing cells of the mammalian hypothalamus. A fluorescent antibody study. Z. Zellforsch. Mikrosk. Anat. 146, 351–366 (1973)
Burlet, A., Marchetti, J., Duheille, J.: Immunohistochemistry of vasopressin: Study of the hypothaiamo-neurohypophyseal system of normal, dehydrated and hypophysectomized rats. In: Neurosecretion — The Final Neuroendocrine Pathway. Knowles, F., Vollrath, L. (eds.). Berlin-Heidelberg-New York: Springer-Verlag 1974, pp. 24–30
Christ, J.F.: Derivation and boundaries of the hypothalamus, with atlas. In: The Hypothalamus. Haymaker, W., Anderson, W., Nauta, W.J.H. (eds.). Springfield: C. Thomas 1969, pp. 13–60
King, J.C., Gerall, A.A., Fishback, J.B., Elkind, K.E., Arimura, A.: Growth hormone-release inhibiting hormone (GH-RIH) pathway of rat hypothalamus revealed by the unlabeled antibody peroxidase-antiperoxidase method. Cell Tissue Res. 160, 423–430 (1975)
Martin, J.B.: Brain regulation of growth hormone secretion. In: Frontiers in Neuroendocrinology. Martini, L., Ganong, W.F. (eds.). New York: Raven Press 1976, Vol. IV, pp. 129–168
Sofroniew, M.V., Weindl, A., Schinko, I., Wetzstein, R.: The distribution of vasopressin, oxytocin and neurophysin producing neurones in the guinea pig brain. I. The classical hypothaiamo-neurohypophyseal system. Cell Tissue Res. (1978) (in preparation)
Sofroniew, M.V., Weindl, A.: The distribution of vasopressin, oxytocin and neurophysin producing neurones in the guinea pig brain. II. Cell groups within the hypothalamus distinct from the supraoptic and paraventricular nuclei. Cell Tissue Res. (1978) (in preparation)
Vandesande, F., De May, J., Dierickx, K.: Identification of neurophysin producing cells. I. The origin of the neurophysin-like substance-containing nerve fibers of the external region of the median eminence of the rat. Cell Tissue Res. 151, 187–200 (1974)
Vandesande, F., Dierickx, K., De Mey, J.: Identification of the vasopressinneurophysin II and the oxytocin-neurophysin I producing neurons in the bovine hypothalamus. Cell Tissue Res. 156, 189–200 (1975)
Weindl, A.: Neuroendocrine aspects of circumventricular organs. In: Frontiers in Neuroendocrinology. Ganong, W.F., Martini, L. (eds.). New York: Oxford University Press 1973, pp. 3–32
Weindl, A., Sofroniew, M.V.: Demonstration of extrahypothalamic peptide secreting neurons. A morphological contribution to the investigation of psychotropic effects of neurohormones. Pharmakopsychiatrie 5, 226–234 (1976)
Zimmerman, E.A.: Localization of hypothalamic hormones by immunocytochemical techniques. In: Frontiers in Neuroendocrinology. Martini, L., Ganong, W.F. (eds.). New York: Raven Press 1976, Vol. IV, pp. 25–62
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Weindl, A., Sofroniew, M.V., Schinko, I. (1978). Distribution of Vasopressin, Oxytocin, Neurophysin, Somatostatin, and Luteinizing Hormone Releasing Hormone-Producing Neurons. In: Bargmann, W., Oksche, A., Polenov, A.L., Scharrer, B. (eds) Neurosecretion and Neuroendocrine Activity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66885-2_101
Download citation
DOI: https://doi.org/10.1007/978-3-642-66885-2_101
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-66887-6
Online ISBN: 978-3-642-66885-2
eBook Packages: Springer Book Archive