Morphology of the Autonomic Nervous System

  • Chapter
Frog Neurobiology

Abstract

The anatomy of the autonomic nervous system of the frog was established during the last century and was first summarized in Ecker’s and Wiedersheim’s famous monography, revised by Gaupp (1899). This description was based mainly on Rana esculenta. Some of the few recent contributions deserve mention, particularly those of Hirt (1934), Nicol (1952) and especially those of Pick (1957, 1970) on Rana pipiens. Here only an outline of the anatomy will be given; the reader is thus invited to consult the above papers for more details.

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Abbreviations

Ach:

Acetylcholine

AChE:

Acetylcholinesterase

ATP:

adenosine-triphosphate

IMAO:

inhibitor of monoamine-oxidase(s)

MAO:

monoamine-oxidase(s)

6-OH-DA:

6-hydroxydopamine

LGV:

large granulated (=dense-cored) vesicles

SGV:

small granulated (= dense-cored) vesicles

SIF:

small intensely fluorescent (cells)

References

  • Abraham, A.: Die mikroskopische Innervation des Herzens der Amphibien. Acta biol. Univ. Szeged. 7, 45–64 (1961).

    Google Scholar 

  • Abraham, A.: Microscopic Innervation of the Heart and Blood Vessels in Vertebrates including Man. Budapest: Akademiai Kiado. London: Pergamon Press 1969.

    Google Scholar 

  • Aikawa, T.: On the innervation of the frog’s stomach. Jap. J. med. Sci. Biophys. 2, 91–129 (1931).

    Google Scholar 

  • Angelakos, E.T., Glassman, P.M., Millard, R.W., King, H.: Regional distribution and subcellular localization of catecholamines in the frog heart. Comp. Biochem. Physiol. 15, 313–324 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Angelakos, E.T., King, H.P.: Demonstration of nerve terminals containing adrenaline by a new histochemical technique. Nature (Lond.) 213, 391–392 (1967).

    Article  CAS  Google Scholar 

  • Ariens Kappers, J.: Survey of the innervation of the Epiphysis cerebri and the accessory pineal organs of Vertebrates. In: Progress in Brain Research (J. Ariens Kappers and J.P. Schade, eds.), vol. 10, p. 87–151. Amsterdam: Elsevier Publ. Co. 1965.

    Google Scholar 

  • Augustinsson, K.B.: Cholinesterases. A study in comparative enzymology. Acta physiol. scand. 15, Suppl. 52, 1–182 (1948).

    Google Scholar 

  • Axelrod, J.: Methylation reactions in the formation and metabolism of catecholamines and other biogenic amines. Pharmacol. Rev. 18, No. 1, 96–113 (1966).

    Google Scholar 

  • Azuma, T., Binia, A., Visscher, M.B.: Adrenergic mechanisms in the bullfrog and turtle. Amer. J. Physiol. 209, 1287–1294 (1965).

    PubMed  CAS  Google Scholar 

  • Banister, J., Mann, S.P.: An investigation of the adrenergic innervation of the heart and major blood vessels of the frog by Falck’s method of fluorescence microscopy. J. Physiol. (Lond.) 181, 13P–15P (1965).

    Google Scholar 

  • Bartoszewicz, W., Barrnett, R.J.: Fine structural localization of nucleoside phosphatase activity in the urinary bladder of the toad. J. Ultrastruct. Res. 10, 599–609 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Baumgarten, H.G., Holstein, A.F., Owman, Ch.: Auerbach’s plexus of mammals and man: electron microscopic identification of three different types of neuronal processes in myenteric ganglia of the large intestine from Rhesus monkeys, guinea-pigs and man. Z. Zellforsch. 106, 376–397 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Bazanova, I.S., Evdokimov, S.A., Majorov, V.N., Merkulova, O.S., Tchernigovski, V.N.: (in Russian) Morphology and electrophysiology of interneuronal synapses in living preparations of parasympathetic ganglia of frog urinary bladder. Fiziol. J. SSSR 51, 309–317 (1965).

    CAS  Google Scholar 

  • Bazanova, I.S., Ivanova, T.S., Petushkov, N.M.: (In Russian) Structural shifts in interneuronal synapses of frog after stimulation of preganglionic fibers with electrical current. Arkh. Anat. Gistol. Embriol. 52, 76–83 (1967).

    PubMed  CAS  Google Scholar 

  • Beale, L.S.: On the structure and formation of the so-called apoiar, unipolar and bipolar nerve cells of the frog. Phil. Trans. 153, 543–569 (1863).

    Article  Google Scholar 

  • Bell, C.: A histochemical study of the esterases in the bladder of the toad (Bufo marinus). Comp. Biochem. Physiol. 21, 91–98 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Bell, C., Burnstock, G.: Cholinesterases in the bladder of the toad (Bufo marinus). Biochem. Pharmacol. 14, 78–89 (1965).

    Article  Google Scholar 

  • Berman, H.J., Siggins, G.R.: Neurogenic factors in the microvascular system. Fed. Proc. 27, 1384–1390 (1968).

    PubMed  CAS  Google Scholar 

  • Bernheim, F.: Die Innervation der Harnblase beim Frosch und Salamander. Arch. Anat. Physiol., Physiol. Abt., 11–28 (1892).

    Google Scholar 

  • Berthold, C.H.: Ultrastructural appearance of glycogen in the B-neurons of the lumbar spinal ganglia of the frog. J. Ultrastruct. Res. 14, 254–267 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Bidder, F.: Die Endigungsweise der Herzzweige des N. vagus beim Frosch. Arch. Anat. Physiol, wiss. Med. 1–50 (1868).

    Google Scholar 

  • Birks, R.B., Katz, B., Miledi, R.: Physiological and structural changes at the amphibian myoneural junction in the course of nerve degeneration. J. Physiol. (Lond.) 150, 145–168 (1960).

    CAS  Google Scholar 

  • Bishop, G.H., O’Leary, J.: Pathways through the sympathetic nervous system in the bullfrog. J. Neurophysiol. 1, 442–454 (1938).

    Google Scholar 

  • Blackman, L.G., Ginsborg, B.L., Ray, C.: Synaptic transmission in the sympathetic ganglion of the frog. J. Physiol. (Lond.) 167, 355–373 (1963).

    CAS  Google Scholar 

  • Bogdanski, D.F., Bonomi, L., Brodie, B.B.: Occurrence of serotonin and catecholamines in brain and peripheral organs of various vertebrate classes. Life Sci. 2, 80–84 (1963).

    Article  CAS  Google Scholar 

  • Botazzi, F.: The action of the vagus and the sympathetic on the oesophagus of the toad. J. Physiol. (Lond.) 25, 157–164 (1899).

    Google Scholar 

  • Boyd, H., Burnstock, G., Rogers, D.: Innervation of the large intestine of the toad (Bufo marinus). Brit. J. Pharmacol. 23, 151–163 (1964).

    PubMed  CAS  Google Scholar 

  • Brecht, K.: Über die Wirkung des Acetylcholins auf die Froschlunge, ihre Beeinflussung und ihre theoretischen Grundlagen. Pflügers Arch. ges. Physiol. 246, 553–576 (1943).

    Article  CAS  Google Scholar 

  • Brecht, K.: Über die Wirkung elektrischer Reizung des Vago-sympathicus auf die glatte Muskulatur der Froschlunge und ihre Beeinflussung durch Ionen bei künstlicher Durchströmung. Pflügers Arch. ges. Physiol. 249, 94–111 (1947).

    Article  CAS  Google Scholar 

  • Brecht, K., Fraessle, K.: Über die Wirkung elektrischer Reizung des Vagosympathicus auf die Froschlunge. Pflügers Arch. ges. Physiol. 247, 649–659 (1944).

    Article  CAS  Google Scholar 

  • Brücke, E.T.: Über die sympathische Innervation der Krötenhaut. Z. Biol. 74, 99–112 (1922).

    Google Scholar 

  • Brzin, M., Tennyson, V.M., Duffy, P.E.: Acetylcholinesterase in frog sympathetic and dorsal root ganglia: a study by electron microscope cytochemistry and microgasometric analysis with the magnetic diver. J. Cell Biol. 31, 215–242 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Brzin, M., Tennyson, V.M., Duffy, P.E.: Ultrastructural, cytochemical and microgasometric studies of isolated neurons of the frog. Int. J. Neuropharmacol. 6, 265–272 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Burnstock, G.: Evolution of the autonomic innervation of visceral and cardiovascular systems in Vertebrates. Pharmacol. Rev. 21, 247–324 (1969).

    PubMed  CAS  Google Scholar 

  • Burnstock, G.: Structure of smooth muscle and its innervation. In: Smooth Muscle (E. Bulbring, A.F. Brading, A.W. Jones and T. Tomita, eds.). London: E. Arnold 1970.

    Google Scholar 

  • Burnstock, G.: Neural nomenclature. Nature (Lond.) 229, 282–283 (1971).

    Article  CAS  Google Scholar 

  • Burnstock, G.: Purinergic nerves. Pharmacol. Rev. 24, 509–581 (1972).

    PubMed  CAS  Google Scholar 

  • Burnstock, G., Campbell, G., Bennett, M., Holman, M.E.: Innervation of the guinea-pig toenia coli: are there intrinsic inhibitory nerves which are distinct from sympathetic nerves? Int. J. Neuropharmacol. 31, 163–166 (1964).

    Google Scholar 

  • Burnstock, G., Campbell, G., Satchell, D., Smythe, A.: Evidence that adenosine-triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Brit. J. Pharmacol. 40, 668–688 (1970).

    CAS  Google Scholar 

  • Burnstock, G., Iwayama, T.: Fine structural identification of autonomic nerves and their relation to smooth muscle. Sympos. on Histoch. of Nervous Transmission (O. Eränkö, ed.). Progr. Brain Res. 34, 389–404 (1971).

    Google Scholar 

  • Burnstock, G., Kirby, S.: Absence of inhibitory effects of catecholamines on lower vertebrate arterial strip preparation. J. Pharm. Pharmacol. 20, 404–406 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Burnstock, G., O’Shea, J., Wood, M.: Comparative physiology of the vertebrate autonomic system. I. Innervation of the urinary bladder of the toad (Bufo marinus). J. exp. Biol. 40, 403–420 (1963).

    PubMed  CAS  Google Scholar 

  • Burnstock, G., Satchell, D.G., Smythe, A.: A comparison of the excitatory and inhibitory effects of non-adrenergic, non-cholinergic nerve stimulation and exogenously applied ATP on a variety of smooth muscle preparations from different vertebrate species. Brit. J. Pharmacol. 46, 234–242 (1972).

    CAS  Google Scholar 

  • Cajal, S.R. y: Nota sobre el plexo de Auerbach de la rana. Trab. Lab. Histol. Fac. Med. Barcelona 23–28 (1892).

    Google Scholar 

  • Campbell, G.: The autonomic innervation of the stomach of a toad (Bufo marinus). Comp. Biochem. Physiol. 31, 693–706 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Campbell, G.: Autonomic innervation of the lung musculature of a toad (Bufo marinus). Comp. gen. Pharmacol. 2, 281–286 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Campbell, G., Burnstock, G.: The comparative physiology of gastrointestinal motility. In: Handbook of Physiology, sect. 6: Alimentary canal IX, p. 2213–2266. Washington D.C.: Amer. Physiol. Soc. 1968.

    Google Scholar 

  • Campbell, G., Burnstock, G., Wood, M.: A method for distinguishing between adrenergic and cholinergic excitatory innervation of smooth muscle. Quart. J. exp. Physiol. 49, 268–276 (1964).

    PubMed  CAS  Google Scholar 

  • Carlson, A.J., Luckhardt, A.B.: Studies on the visceral sensory nervous system. I. Lung automatism and lung reflexes in the frog. (R. pipiens and R. catesbiana). Amer. J. Physiol. 54, 55–95 (1920).

    Google Scholar 

  • Carlson, A.J., Luckhardt, A.B.: Studies on the visceral sensory nervous system. X. The vagus control of the oesophagus. Amer. J. Physiol. 57, 299–335 (1921).

    Google Scholar 

  • Carter, R.H.: Resistance to tetrodotoxin in toad sympathetic nerves. J. Pharm. Pharmacol. 21, 394–395 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Chacko, C.W., Cerf, J.A.: Histochemical localization of Cholinesterase in the Amphibian spinal cord and alterations following ventral root section. J. Anat. (Lond.) 94, 75–81 (1960).

    Google Scholar 

  • Chernetski, K.E.: Cephalic sympathetic fibers in the frog. J. comp. Neurol. 122, 173–179 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Cole, E.C.: Anastomosing cells in the myentericus plexus of the frog. J. comp. Neurol. 38, 375–387 (1925).

    Article  Google Scholar 

  • Cole, E.C.: Notes on the extent and organization of the myenteric plexus in the frog. J. comp. Neurol. 41, 311–317 (1926).

    Article  Google Scholar 

  • Contejean, C.: Action des nerfs pneumogastrique et grand sympathique sur l’estomac chez les Batraciens. Arch. Physiol, norm, pathol., 24ème sér., 4, 640–650 (1892).

    Google Scholar 

  • Couteaux, R.: Principaux critères morphologiques et cyto-chimiques utilisables aujourd’hui pour définir les divers types de synapses. In: Actualités Neurophysiologiques (A. Monnier, ed.), 3ème sér., p. 145–173. Paris: Masson 1961.

    Google Scholar 

  • Couteaux, R., Taxi, J.: Recherches histochimiques sur la distribution des activités cholinestérasiques au niveau de la synapse myoneurale. Arch. Anat. micr. Morph, exp. 41, 352–392 (1952).

    Google Scholar 

  • Couvreur, E.: Influence de l’excitation du pneumogastrique sur la circulation pulmonaire de la Grenouille. C. R. Acad. Sci. (Paris) 109, 823–825 (1889).

    Google Scholar 

  • Dahlström, A.: Observations on the accumulation of noradrenaline in the proximal and distal parts of peripheral adrenergic nerves after compression. J. Anat. (Lond.) 99, 677–689 (1965).

    Google Scholar 

  • Dahlström, A., Häggendal, J.: Studies on the transport and life-span of amine storage granules in a peripheral adrenergic neuron system. Acta physiol. scand. 67, 278–288 (1966).

    Article  PubMed  Google Scholar 

  • Dale, H.H.: Observations, chiefly by the degeneration method, on possible efferent fibers in the dorsal nerve roots of the toad and frog. J. Physiol. (Lond.) 27, 350–355 (1901).

    CAS  Google Scholar 

  • Dedyulin, Ya.A.: The vasomotor apparatus of the frog and the rabbit. Med. Vestn. 30, 277 (1865). (Quoted from Gri-gor’eva, 1962.)

    Google Scholar 

  • Dehler, A.: Beitrag zur Kenntnis vom feineren Bau der sympathischen Ganglienzellen des Frosches. Arch. mikr. Anat. 46, 724–739 (1895).

    Article  Google Scholar 

  • Dennis, M.J., Harris, A.J., Kuffler, S.W.: Synaptic transmission and its duplication by focally applied acetylcholine in parasympathetic neurons in the heart of the frog. Proc. roy. Soc. B 177, 503–539 (1971).

    Article  Google Scholar 

  • De Robertis, E., Bennett, H.S.: A submicroscopic vesicular component in nerve satellite cells and in Schwann cells. Anat. Rec, Suppl. 118, 294 (1954).

    Google Scholar 

  • De Robertis, E., Bennett, H.S.: Some features of the submicroscopic morphology of synapses in frog and earthworm. J. bioph. biochem. Cytol. 1, 47–56 (1955).

    Article  Google Scholar 

  • De Robertis, E., Bennett, H.S.: Un composant submicroscopique vésiculaire des cellules de Schwann et des cellules satellites des ganglions. C.R. Soc. Biol. (Paris) 150, 1654–1655 (1956).

    Google Scholar 

  • Dhalla, N.S., MacLain, P.L.: Effect of cardio-active drugs on the rate, contractile force and Phosphorylase activity in the frog heart. Arch. int. Pharmacodyn. 163, 272–282 (1966).

    CAS  Google Scholar 

  • Dixon, W.E.: The innervation of the frog’s stomach. J. Physiol. (Lond.) 28, 57–75 (1902).

    CAS  Google Scholar 

  • Dogiel, A.S.: Zur Frage über den feineren Bau des sympathischen Nervensystems bei den Säugethieren. Arch. mikr. Anat. 46, 305–344 (1895).

    Article  Google Scholar 

  • Dogiel, J.: Die Nervenzellen und Nerven des Herzventrikels beim Frosch. Arch. mikr. Anat. 21, 21–25 (1882).

    Article  Google Scholar 

  • Doi, Y.: On the existence of antidromic fibers in the frog, and their influence on the capillaries. J. Physiol. (Lond.) 54, 227–238 (1920).

    CAS  Google Scholar 

  • Dumont, L.: L’innervation cholinergique du muscle vésical. C.R. Acad. Sci. (Paris) 239, 194–200 (1954).

    CAS  Google Scholar 

  • Ehrlich, P.: Ueber die Methylenblaureaktion der lebenden Nervensubstanz. Biol. Zbl. 6, 214–224 (1886).

    Google Scholar 

  • Elliott, I.R.: The action of adrenalin. J. Physiol. (Lond.) 32, 401–467 (1905).

    Google Scholar 

  • Epstein, D.: The responses of the excised batrachian alimentary canal to autonomic drugs. I. Xenopus laevis (the South African clawed toad)-pilocarpine, physostigmine, adrenaline. J. Pharmacol, exp. Ther. 43, 653–675 (1931).

    CAS  Google Scholar 

  • Epstein, D.: The responses of the batrachian alimentary canal to autonomic drugs. Xenopus laevis (the South African clawed toad)-arecholine. Quart. J. exp. Physiol. 22, 1–5 (1932a).

    CAS  Google Scholar 

  • Epstein, D.: The responses of the batrachian alimentary canal to autonomic drugs. Rana and Bufo-arecholine. J. Physiol. (Lond.) 75, 99–111 (1932b).

    CAS  Google Scholar 

  • Eränkö, O., Härkönen, M.: Histochemical demonstration of fluorogenic amines in the cytoplasm of sympathetic ganglion cells of the rat. Acta physiol. scand. 58, 285–286 (1963).

    Article  Google Scholar 

  • Erlij, D., Centrangolo, R., Valadez, R.: Adrenotropic receptors in the frog. J. Pharmacol, exp. Therap. 149, 65–70 (1965).

    CAS  Google Scholar 

  • Erspramer, V.: Occurence of indolealkylamines in nature. In: Handbuch der experimentellen Pharmakologie (O. Eichler and A. Farah, eds.), vol. XIX, 5-hydroxytryptamine and related indolealkylamines (V. Erspramer, sub-ed.), p. 132–181. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Eugling, M.: Untersuchungen über die peripheren Tonus der Blutgefässe. Pflügers Arch. ges. Physiol. 121, 275–297 (1908).

    Article  Google Scholar 

  • Euler, U.S. von: A specific sympathomimetic ergone in adrenergic nerve fibers (sympathin) and its relation to adrenaline and noradrenaline. Acta physiol. scand. 12, 73–97 (1946).

    Article  Google Scholar 

  • Euler, U.S. von: Noradrenaline, pp. 150–153. Springfield: C. Thomas 1956.

    Google Scholar 

  • Falck, B., Häggendal, J., Owman, Ch.: The localization of adrenaline in adrenergic nerves in the frog. Quart. J. exp. Physiol. 48, 253–257 (1963).

    CAS  Google Scholar 

  • Falck, B., Hillarp, N.A., Thieme, G., Torp, A.: Fluorescence of catecholamines and related compounds condensed with formaldehyde. J. Histochem. Cytochem. 10, 348–354 (1962).

    Article  CAS  Google Scholar 

  • Fedorow, B.G.: Essai de l’étude intravitale des cellules nerveuses et des connexions interneuronales dans le système nerveux autonome. Trav. Lab. Rech. Biol. Univ. Madrid 30, 403–434 (1935).

    Google Scholar 

  • Fedorow, B.G., Matwejewa, S.J.: La structure des connexions interneuronales dans le système nerveux autonome dela Grenouille Trav. Lab. Rech. Biol. Univ. Madrid 30, 379–401 (1935).

    Google Scholar 

  • Florkin, M.: Automatisme et inhibition au niveau de l’intestin terminal chez la Grenouille. Arch. int. Physiol. 30, 73–76 (1928).

    Google Scholar 

  • Freedman, B.: Microscopy of synapses of non-excised frog heart. Proc. Soc. exp. Biol. (N.Y.) 80, 399–400 (1952).

    CAS  Google Scholar 

  • Friedman, M.H.F.: Oesophagal and gastric secretion in the frog. J. cell. comp. Physiol. 37, 37–50 (1937).

    Article  Google Scholar 

  • Fujimoto, S.: Some observations on the fine structure of the sympathetic ganglion of the toad, Bufo vulgaris japonicus. Arch. Histol. Jap. 28, 313–335 (1967).

    PubMed  CAS  Google Scholar 

  • Fulton, G.P., Lutz, B.R.: Neuro-motor mechanism of the small blood vessels of the frog. Science 92, 223–224 (1940).

    Article  PubMed  CAS  Google Scholar 

  • Gaskell, W.H.: On the action of the sympathetic nerves upon the heart of the frog. J. Physiol. (Lond.) 5, XIII–XV (1884).

    Google Scholar 

  • Gaskell, W.H.: On the structure, distribution and function of the nerves which innervate the visceral and vascular systems. J. Physiol. (Lond.) 7, 1–80 (1886).

    CAS  Google Scholar 

  • Gasser, H.S.: Discussion. In: The hypothesis of saltatory conduction. Cold Spr. Harb. Symp. quant. Biol. 17, 32–36 (1952).

    Google Scholar 

  • Gaupp, E.: Ecker’s and Wiedersheim’s Anatomie des Frosches. II. S. 214–227. Braunschweig: F. Vieweg 1899.

    Google Scholar 

  • Geffen, L.B., Descarries, L., Droz, B.: Intraaxonal migration of 3H-norepinephrine injected into the coeliac ganglion of cats: radioautographic study of the proximal segment of constricted splenic nerves. Brain Res. 35, 315–318 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Geffen, L.B., Livett, B.G., Rush, R.A.: Immunohistochem-ical localization of protein components of catecholamine storage vesicles. J. Physiol. (Lond.) 204, 593–605 (1969).

    CAS  Google Scholar 

  • Gerlach, L.: Ueber die Nervenendigungen in der Muskulatur des Froschherzens. Arch. Path. Anat. Physiol. klin. Med. 66, 3–39 (1874).

    Google Scholar 

  • Giacobini, E.: Histochemical demonstration of AChE activity in isolated nerve cells. Acta physiol. scand. 36, 276–290 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Giacobini, E.: Quantitative determination of Cholinesterase in individual sympathetic cells. J. Neurochem. 1, 234–244 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Gillard, S.M., Read, J.B.: Fluorescenthistochemical studies on the effects of 6-hydroxydopamine on adrenaline-containing nerves in the toad. Z. Zellforsch. 118, 493–511 (1971).

    Article  PubMed  Google Scholar 

  • Girardier, L., Baumann, F., Posternak, J.M.: Recherches sur les cholinestérases cardiaques. Helv. physiol. pharmacol. Acta 18, 467–481 (1960).

    PubMed  CAS  Google Scholar 

  • Goltz, F.: Studien über die Bewegungen der Speiseröhre und des Magen des Frosches. Pflügers Arch. ges. Physiol. 6, 616–642 (1872).

    Google Scholar 

  • Govyrin, V.A., Leontieva, G.R.: Influence of elimination of sympathetic nerve supply on content and accumulation of catecholamines in cardiac muscle of the frog. Fiziol. J. SSSR 49, 566–569 (1963). [In Russian.]

    CAS  Google Scholar 

  • Gramenitzky, M.I.: Einige Methoden zur Beobachtung der Tätigkeit des Froschherzens. In: Handbuch der biologischen Arbeitsmethoden, Abt. V, vol. 8, p. 953–963. Berlin-Wien: Urban und Schwarzenberg 1934.

    Google Scholar 

  • Gray, E.G., Guillery, R.W.: Synaptic morphology in the normal and degenerating nervous system. Int. Rev. Cytol. 19, 111–182 (1966).

    Google Scholar 

  • Grigor’eva, T.A.: The Innervation of Blood Vessels. New York-London: Pergamon Press 1962.

    Google Scholar 

  • Grimley, P.M., Edwards, G.A.: The ultrastructure of cardiac desmosomes in the toad and their relationship to the intercalated disc. J. biophys. biochem. Cytol. 8, 305–318 (1960).

    Article  PubMed  CAS  Google Scholar 

  • Gunn, M.: A study of the enteric plexuses in some amphibians. Quart. J. micr. Sci. 92, 55–77 (1951).

    Google Scholar 

  • Hallerstein, H. von: Kranialnerven. In: Handbuch der vergleichenden Anatomie der Wirbeltiere (L. Bolk, E. Goppert, E. Kallius, W. Lubosch, eds.), p. 681 et seq. Berlin-Wien: Urban & Schwarzenberg 1934.

    Google Scholar 

  • Hardesty, I.: The number and arrangement of the fibers forming the spinal nerves of the frog. (Rana virescens). J. comp. Neurol. 9, 64–112(1899).

    Google Scholar 

  • Hato, H.: Effects of the electric stimulation of the peripheral cut end of the rami communicantes and of the splanchnic nerve upon the movements of the frog’s stomach. J. Physiol. Soc. Jap. 20, 388–396 (1958a). [In Japanese, English summary.]

    Google Scholar 

  • Hato, H.: Effects of the electric stimulation of the peripheral cut end of the spinal ventral and dorsal roots upon the movements of the frog’s stomach. J. Physiol. Soc. Jap. 20, 397–400 (1958b). [In Japanese, English summary.]

    Google Scholar 

  • Hato, H.: Effects of the electric stimulation of the peripheral cut end of the vagosympathetic nerves on the movements of the frog’s stomach. J. Physiol. Soc. Jap. 20, 401–406 (1958c). [In Japanese, English summary.]

    Google Scholar 

  • Hato, H.: On the motor fibers in the gastric movements passing via the posterior roots of the frog. J. Physiol. Soc. Jap. 20, 416–421 (1958d). [In Japanese, English summary.]

    Google Scholar 

  • Hebb, C.: Formation, storage and liberation of acetylcholine. In: Handbuch der experimentellen Pharmakologie (O. Eichler, and A. Farah, eds.), vol. XV, Cholinesterases and Anticholinesterase Agents (G. Koelle, sub-ed.), p. 55–88. Berlin-Heidelberg-New York: Springer 1963.

    Google Scholar 

  • Heymans, J.F.: Ueber Innervation des Froschherzens. Arch. Anat. Physiol., Physiol. Abt. 391 (1893).

    Google Scholar 

  • Hillarp, N.Å.: Structure of the synapse and the peripheral innervation apparatus of the autonomic nervous system. Acta anat. (Basel), Suppl. IV, 1–153 (1946).

    Google Scholar 

  • Hillarp, N.Å.: The construction and functional organization of the autonomic innervation apparatus. Acta physiol. scand. 46, Suppl. 157, 1–38 (1959).

    Google Scholar 

  • Hillarp, N.Å., Hökfelt, B.: Histochemical demonstration of noradrenaline and adrenaline in the adrenal medulla. J. Histochem. Cytochem. 3, 1–5 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Hirt, A.: Zur Innervation der Niere und Nebenniere des Frosches. Z. Anat. Entwickl.-Gesch. 91, 580–593 (1930).

    Article  Google Scholar 

  • Hirt, A.: Die vergleichende Anatomie des sympathischen Nervensystem. In: Handbuch der vergleichenden Anatomie der Wirbeltiere (L. Bolk, E. Göppert, E. Kallius and W.L. Lubosch, eds.), vol. II, p. 709–712. Berlin-Wien: Urban & Schwarzenberg 1934.

    Google Scholar 

  • Hofmann, F.B.: Das intracardiac Nervensystem des Frosches. Arch. Anat. Physiol., Anat. Abt. 54–114 (1902).

    Google Scholar 

  • Hökfelt, T.: In vitro studies on central and peripheral monoamine neurons at the ultrastructural level. Z. Zellforsch. 91, 1–74 (1968).

    Article  PubMed  Google Scholar 

  • Hopf, H.: Studien über antagonistische Nerven. VII. Uber den hemmenden und erregenden Einfluss des Vagus auf den Magen des Frosches. Z. Biol. 55, 409–459 (1911).

    Google Scholar 

  • Horton Smith, R.J.: On efferent fibers in the posterior roots in the frog. J. Physiol. (Lond.) 21, 101–111 (1897).

    CAS  Google Scholar 

  • Horvath, I.: Comparative cytological examinations of the paravertebral ganglia of tadpoles and full-grown frogs. Acta biol. Univ. Szeged 12, 93–99 (1966).

    Google Scholar 

  • Horvath, I.: Zinc-iodide-osmium impregnated cells in the paravertebral bundle of the marsh-frog (Rana ridibunda Pall.) Acta biol. Univ. Szeged 17, 153–158 (1971).

    CAS  Google Scholar 

  • Huber, G.C.: Four lectures on the sympathetic nervous system. J. comp. Neurol. 7, 73–145 (1897).

    Article  Google Scholar 

  • Huber, G.C.: A contribution on the minute anatomy of the sympathetic ganglia of the different classes of Vertebrates. J. Morph. 16, 27–90 (1900).

    Article  Google Scholar 

  • Hukovic, S., Igic, R., Brkic, S.: Reaction of the isolated nerves of lung to electrical stimulation of the associated nerves and to physiologically active substances. Jugoslav, physiol. Pharmacol. Acta 2–3, 119–127 (1965). (Quoted from Burnstock, 1969.)

    Google Scholar 

  • Hunt, C.C., Nelson, P.G.: Structural and functional changes in the frog sympathetic ganglion following cutting of the presynaptic nerve fibers. J. Physiol. (Lond.) 177, 1–20 (1965).

    CAS  Google Scholar 

  • Hutter, O.F., Loewenstein, W.R.: Nature of neuromuscular facilitation by sympathetic stimulation in the frog. J. Physiol. (Lond.) 130, 559–571 (1955).

    CAS  Google Scholar 

  • Itagaki, M.: On the innervation of the stomach of the Japanese frog. Jap. J. med. Sci. 1, 105 (1929). (Quoted from Aikawa, 1931.)

    Google Scholar 

  • Johnson, S.E.: On the question of commissural neurones in the sympathetic ganglia. J. comp. Neurol. 29, 385–404 (1918).

    Article  Google Scholar 

  • Jullien, A., Ripplinger, J.: De l’existence de cellules ganglionnaires sur le trajet du pneumogastrique de la Grenouille, Ann. Sci. Univ. Besançon 1, 79–83 (1954).

    Google Scholar 

  • Kirby, S.E., Burnstock, G.: Comparative pharmacological studies of isolated spiral strips of large arteries from lower Vertebrates. Comp. Biochem. Physiol. 28, 307–319 (1969a).

    Article  PubMed  CAS  Google Scholar 

  • Kirby, S.E., Burnstock, G.: Pharmacological studies of the cardiovascular system in the anaesthetised sleepy lizard (Til-iqua rugosa) and toad (Bufo marinus). Comp. Biochem. Physiol. 28, 321–332 (1969b).

    Article  PubMed  CAS  Google Scholar 

  • Kisch, B.: Electron microscopy of the frog’s heart. Exp. Med. Surg. 19, 104–142 (1961).

    PubMed  CAS  Google Scholar 

  • Knowlton, F.P.: Observations on the effect of stimulation of the eight and ninth spinal nerve roots upon the bladder of the toad. J. Physiol. (Lond.) 43, 91–95 (1911).

    CAS  Google Scholar 

  • Kobayasi, S., Yoda, C.: Effects of adrenaline and acetylcholine upon the smooth muscle of isolated lungs of Japanese toads Acta med. biol. (Niigata) 8, 241–250 (1960).

    Google Scholar 

  • Krogh, A.: Studies on the capillariomotor mechanism. I. The reaction to stimuli and the innervation of the blood vessels in the tongue of the frog. J. Physiol. (Lond.) 53, 399–419 (1920).

    CAS  Google Scholar 

  • Krogh, A., Harrop, G.A., Brandt Rehberg, P.: Studies on the physiology of capillaries III. The innervation of the blood vessels of the hind legs of the frog. J. Physiol. (Lond.) 56, 179–189 (1922).

    CAS  Google Scholar 

  • Kumar, S.: Nerve endings in the heart of Amphibia. Mikroskopie 27, 235–241 (1971).

    PubMed  CAS  Google Scholar 

  • Laduron, P., Belpaire, F.: Transport of noradrenaline and dopamine-hydroxylase. Life Sci. 7, 1–7 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Langley, J.N.: Degenerative changes in nerve endings in striated muscle, in nerve plexuses on arteries and in nerve fibers of frog. J. Physiol. (Lond.) 38, 504–512 (1909).

    CAS  Google Scholar 

  • Langley, J.N.: The origin and course of the vaso-motor fibres of the frog’s foot. J. Physiol. (Lond.) 41, 483–498 (1911).

    CAS  Google Scholar 

  • Langley, J.N., Orbeli, L.A.: Observations on the sympathetic and sacral autonomic system of the frog. J. Physiol. (Lond.) 41, 450–482 (1910).

    CAS  Google Scholar 

  • Langley, J.N., Orbeli, L.A.: Some observations on the degeneration in the sympathetic and sacral autonomic nervous system of Amphibia. J. Physiol. (Lond.) 42, 113–124 (1911).

    CAS  Google Scholar 

  • Lawrentjew, B.J., Fedorow, B.G.: Observations of living synapses in the frog’s heart. Bull. Vses. Inst. exp. Med. Moscow 8–9, 6–7 (1934). [In Russian.]

    Google Scholar 

  • Leibovitz, A.: The growth and maintenance of tissue-cell cultures in free gas exchange with the atmosphere. Amer. J. Hyg. 78, 173–180 (1963).

    PubMed  CAS  Google Scholar 

  • Leontowitsch, A.: Zur Frage der Gefässinnervation bei Rana esculenta. Int. Mschr. Anat. Physiol. 23, 1–18 (1906).

    Google Scholar 

  • Leontowitsch, A.: Über die Ganglienzellen der Blutgefässe. Z. Zellforsch. 11, 23–45 (1930).

    Article  Google Scholar 

  • Lissák, K.: Effects of extracts of adrenergic fibers on the frog heart. Amer. J. Physiol. 125, 778–785 (1939).

    Google Scholar 

  • Livett, B.G., Geffen, L.B., Austin, L.: Proximal-distal transport of 14C-noradrenaline and protein in sympathetic nerves. J. Neurochem. 15, 931–939 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Loewi, O.: Ueber humorale Uebertragbarkeit der Herznerven-wirkung. Pflügers Arch. ges. Physiol. 189, 239–242 (1921).

    Article  Google Scholar 

  • Loewi, O.: Quantitative und qualitative Untersuchungen über den Sympathicusstoff. Pflügers Arch. ges. Physiol. 237, 504–514 (1936).

    Google Scholar 

  • Loewi, O., Navratil, L.: Über humorale Übertragbarkeit der Herznervenwirkung. X. Mitt. Über das Schicksal des Vagusstoffs. Pflügers Arch. ges. Physiol. 214, 679–688 (1926).

    Google Scholar 

  • Lucas, A., Miksicek, J.E.: Nerve cells without central processes in the fourth spinal ganglion of the bullfrog. Science 84, 207–208 (1936).

    Article  PubMed  CAS  Google Scholar 

  • Luckhardt, A.B., Carlson, A.J.: Studies on the visceral sensory nervous system. VIII. On the presence of vasomotor fibers in the vagus nerve to pulmonary vessels of the amphibian and reptilian lung. Amer. J. Physiol. 56, 72–112 (1921).

    Google Scholar 

  • Ludwig, C.: Ueber die Herznerven des Frosches. Arch. Anat. Physiol, wiss. Med. 139–143 (1848).

    Google Scholar 

  • Lutz, B.R., Fulton, G.P., Akers, R.P.: The neuromotor mechanism of the small blood vessels in membranes of the frog (Rana pipiens) and the hamster (Mesocricetus auratus) with reference to the normal and pathological conditions of blood flow. Exp. Med. Surg. 8, 258–287 (1950).

    PubMed  CAS  Google Scholar 

  • MacLean, J.R., Bell, C., Burnstock, G.: Histochemical and pharmacological studies on the innervation of the urinary bladder of the frog (Rana temporaria). Comp. Biochem. Physiol. 21, 383–392 (1967).

    Article  Google Scholar 

  • MacLean, J.R., Burnstock, G.: Histochemical localization of catecholamines in the urinary bladder of the toad (Bufo marinus). J. Histochem. Cytochem. 14, 538–548 (1966).

    Article  Google Scholar 

  • MacLean, J.R., Burnstock, G.: Innervation of the lungs of the toad (Bufo marinus). II. Fluorescent histochemistry of catecholamines. Comp. Biochem. Physiol. 22, 767–773 (1967).

    Article  Google Scholar 

  • MacLean, J.R., Burnstock, G.: Axoplasmic flow of adrenaline and monoamine-oxidase in amphibian sympathetic nerves. Z. Zeilforsch. 124, 44–56 (1972).

    Google Scholar 

  • MacMahan, U.J., Kuffler, S.W.: Viewing cholinergic synaptic areas on living nerve cells of the frog’s heart. In: Excitatory Synaptic Mechanisms (P. Andersen and J.K.S. Jansen, eds.), p. 57–66. Oslo: Universitetsforlaget 1970.

    Google Scholar 

  • MacMahan, U.J., Kuffler, S.W.: Visual identification of synaptic boutons on living ganglion cells and varicosities in postganglionic axons in the heart of the frog. Proc. roy. Soc. B 177, 485–508 (1971).

    Article  Google Scholar 

  • Maillet, M.: Le réseau sympathique terminal du rein (Rana escul.). Bull. Ass. Anat. 74, 474–478 (1953).

    Google Scholar 

  • Maillet, M.: Innervation sympathique du rein: son rôle trophique. Acta neuroveg. (Wien) 20, 155–180 (1959).

    Article  CAS  Google Scholar 

  • Maillet, M.: La technique de Champy à losmium-iodure de potassium et la modification de Maillet à l’osmium-iodure de zinc. Trab. Inst. Cajal Invest, biol. 54, 1–36 (1962).

    CAS  Google Scholar 

  • Majcen, Z., Brzin, M.: Localization and activity of cholinester-ases in Bidder’s ganglion cells and nerve fibers of frog heart. Histochemie 25, 217–224 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Majorow, V.N.: Lebendbeobachtung der interneuronalen Verbindungen und Rezeptoren in der Harnblase. Z. mikr.-anat. Forsch. 63, 442–449 (1957).

    PubMed  CAS  Google Scholar 

  • Majorow, V.N.: Über den Aufbau der lebenden perizellulären Apparate. Z. mikr.-anat. Forsch. 65, 547–556 (1959).

    PubMed  CAS  Google Scholar 

  • Majorow, V.N.: Über die Dynamik der lebenden interneuronalen Verbindungen (Synapsen) unter experimentellen Bedingungen. Z. mikr.-anat. Forsch. 66, 266–289 (1960).

    Google Scholar 

  • Majorow, V.N.: (in Russian) On the dynamics of structural changes in living interneuronale junctions (synapses) in experimental conditions. Trud. Inst. Physiol. Pavlov 10, 346–361 (1962).

    Google Scholar 

  • Majorow, V.N.: Lebendbeobachtungen über die Struktur des perizellulären Apparatus in der argentophoben (farblosen) Phase. Z. mikr.-anat. Forsch. 69, 533–568 (1963).

    PubMed  CAS  Google Scholar 

  • Majorow, V.N.: Morphology of the reactive states of a vegetative interneuronal synapse (experimental research in vitro). Leningrad: Nauka 1969. [In Russian.]

    Google Scholar 

  • Marceau, F.: Lieux de terminaison des fibres du pneumogastrique dans le coeur des Batraciens (Grenouille, Crapaud). C.R. Soc. Biol. (Paris) 140, 286–288 (1946).

    Google Scholar 

  • Märki, F., Axelrod, J., Witkop, B.: Catecholamines and methyltransferases in the South American toads (Bufo marinus). Biochim. biophys. Acta (Amst.) 58, 367–369 (1962).

    Article  Google Scholar 

  • Matty, A.J., Guiness, F.I.: The histochemistry of the urinary bladder of the toad, Bufo marinus, in relation to hormonal studies. J. Anat. (Lond.) 98, 271–275 (1964).

    CAS  Google Scholar 

  • Meves, H.: Die Wirkung von Adrenalin und Adrenalinverwandten auf Gefäße und Muskulatur der Froschlunge. Pflügers Arch. ges. Physiol. 258, 200–210 (1953).

    Article  CAS  Google Scholar 

  • Michailow, S.: Das intracardiac Nervensystem des Frosches und die Methode von R. Cajal. Int. Mschr. Anat. Physiol. 25, 351–372 (1908).

    Google Scholar 

  • Miller, F.: Acid phosphatase localization in renal protein absorption droplets. Proceed. Vth international Congress for electron microscopy. Philadelphia Q2. New York: Acad. Press 1962.

    Google Scholar 

  • Mitchell, H.C., Thaemert, J.C.: Three dimensions in fine structure. Science 148, 1480–1482 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Muller, R.: Über die Nervenversorgung des Magendarmkanals beim Frosch durch Nervennetze. Pflügers Arch. ges. Physiol. 123, 387–405 (1908).

    Article  Google Scholar 

  • Nelemans, F.A.: Innervation of the smallest blood vessels. Amer. J. Anat. 83, 43–58 (1948).

    Article  PubMed  CAS  Google Scholar 

  • Nelemans, F.A.: Liberation of sympathin and acetylcholine by faradic stimulation of the frog’s heart. Acta physiol. Pharmacol, neerl. 2, 51–62 (1951).

    CAS  Google Scholar 

  • Nemiloff, A.: Zur Frage des Nerven des Darmcanals bei den Amphibien. Trav. Soc. imp. Nat. Petersbourg 32 (2), 59–88 (1902).

    Google Scholar 

  • Nickerson, M., Nomaguchi, G.M.: Blockade of epinephrine-induced cardioacceleration in the frog. Amer. J. Physiol. 163, 484–490 (1950).

    PubMed  CAS  Google Scholar 

  • Nigol, J.A.C.: Autonomic nervous system in lower chordates. Biol. Rev. 27, 1–49 (1952).

    Article  Google Scholar 

  • Nikiforowsky, P.M.: On depressor nerve fibers in the vagus of the frog. J. Physiol. (Lond.) 45, 459–461 (1913).

    CAS  Google Scholar 

  • Nikolajew, W.: Zur Frage über die Innervation des Froschherzens. Arch. Anat. Physiol., Physiol. Abt., Suppl., 67–73 (1893).

    Google Scholar 

  • Nikolajew, W.: The vasomotor nerves of the lungs of the frog. Nevrol. Vestn. 10, 12 (1902).

    Google Scholar 

  • Nishi, S., Soeda, H., Koketsu, K.: Studies on sympathetic B and C neurons and patterns of preganglionic innervation. J. cell. comp. Physiol. 66, 19–32 (1965).

    Article  CAS  Google Scholar 

  • Nishi, S., Soeda, H., Koketsu, K.: Release of acetylcholine from sympathetic preganglionic nerve terminals. J. Neurophysiol. 30, 114–134(1967).

    CAS  Google Scholar 

  • Norberg, K.A., MacIsaac, R.J.: Cellular location of adrenergic amines in frog sympathetic ganglia. Experientia (Basel) 23, 1052 (1967).

    Article  CAS  Google Scholar 

  • Norberg, K.A., Ritzen, M., Ungerstedt, U.: Histochemical studies on special catecholamine-containing cell type in sympathetic ganglia. Acta physiol. scand. 67, 260–270 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Novikoff, A.B.: Lysosomes in nerve cells. In: The Neuron (H. Hyden, ed.), p. 319–377. Amsterdam-London-New York: Elsevier Publ. Co. 1967.

    Google Scholar 

  • Novikoff, A.B., Shin, W.Y.: The endoplasmic reticulum in the Golgi zone and its relations to microbodies, Golgi apparatus and autophagic vacuoles in rat liver cells. J. Microscopie (Paris) 3, 187–206 (1964).

    Google Scholar 

  • Novikoff, P.M., Novikoff, A.B., Quintana, N., Hauw, J.J.: Golgi apparatus, GERL and lysosomes of neurons in rat dorsal root ganglia, studied by thick section and thin section cytochemistry. J. Cell Biol. 50, 859–886 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Oinuma, S.: On the question of the presence in the frog of vasodilator fibers in the posterior roots of the nerves supplying the foot and in the sciatic nerve. J. Physiol. (Lond.) 43, 343–346(1911).

    CAS  Google Scholar 

  • Okamura, C.: Die Ganglien in der Wand der Bronchien und Alveolen von Mammalien und Amphibien. Z. mikr.-anat. Forsch. 41, 627–639 (1937).

    Google Scholar 

  • Orbeli, L.A.: Die sympathische Innervation des Skelettmuskeln. Bull. Inst. Sci. Leshaft 6, 194–197 (1923). (Quoted from Hutter and Loewenstein, 1955.)

    Google Scholar 

  • Ostlund, E.: The distribution of catecholamines in lower animals and their effect on the heart. Acta physiol. scand. 31, Suppl. 112 (1954).

    Google Scholar 

  • Palay, S.L.: Synapses in the central nervous system. J. biophys. biochem. Cytol. 2, 193–202 (1956).

    Article  PubMed  CAS  Google Scholar 

  • Palay, S.L.: The morphology of synapses in the central nervous system. Exp. Cell Res., Suppl. 5, 275–293 (1958).

    Google Scholar 

  • Palay, S.L., Palade, G.E.: The fine structure of neurons. J. biophys. biochem. Cytol. 1, 69–88 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Palay, S.L., Sotelo, C., Peters, A., Orkand, P.M.: The axon hillock and the initial segment. J. Cell Biol. 38, 193–201 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Patterson, N.F.: The head of Xenopus laevis. Quart. J. micr. Sci. 81, 161–234 (1939).

    Google Scholar 

  • Patterson, T.L.: Gastric tonus of the empty stomach of the frog. Amer. J. Physiol. 54, 153–165 (1920a).

    Google Scholar 

  • Patterson, T.L.: Vagus and splanchnic influence on the gastric hunger movements of the frog. Comparative studies. III. Amer. J. Physiol. 53, 293–306 (1920 b).

    Google Scholar 

  • Pick, J.: Sympathectomy in Amphibians (Anatomical considerations). J. comp. Neurol. 107, 169–207 (1957).

    Article  PubMed  CAS  Google Scholar 

  • Pick, J.: On the organization of myelinated sympathetic nerve fiber in the frog (Rana pipiens). Anat. Rec. 144, 295–326 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Pick, J.: The submicroscopic organization of the sympathetic ganglion in the frog (Rana pipiens). J. comp. Neurol. 120, 409–462 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Pick, J.: The fine structure of sympathetic neurons in X-irradiated frogs. J. Cell Biol. 26, 335–351 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Pick, J.: The Autonomic Nervous System, p. 107–132 and 215–239. Philadelphia: J.B. Lippincott 1970.

    Google Scholar 

  • Piezzi, R.S., Rodriguez-Echandia, E.L.: Studies on the pararenal ganglion of the toad, Bufo arenarum Hensel. I. Its normal fine structure and histochemical characteristics. Z. Zellforsch. 88, 180–186 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Polumordwinow, D.: Über die Rolle der Nervenzellen des Froschherzens. Pflügers Arch. ges. Physiol. 140, 463–470 (1911).

    Article  Google Scholar 

  • Prentiss, C.W.: The nervous structures in the palate of the frog: the peripheral networks and the nature of their cells and fibers. J. comp. Neurol. 14, 93–117 (1904).

    Article  Google Scholar 

  • Ranvier, L.: Leçons d’anatomie générale. Appareils nerveux terminaux des muscles de la vie organique. Paris: J.B. Baillère 1880.

    Google Scholar 

  • Rapela, C.E.: Sensibilidad del recto de sapo y de la rata para la adrenalina y noradrenalina. Rev. Soc. Argent. Biol. 27, 260–262 (1951).

    PubMed  CAS  Google Scholar 

  • Rashid, S.: The nature of the parasympathetic nerve fibers of the stomach of Rana temporaria. Arch. int. Pharmacodyn. 195, 247–251 (1972).

    PubMed  CAS  Google Scholar 

  • Read, J.B., Burnstock, G.: Comparative histochemical studies of adrenergic nerves in the enteric plexuses of vertebrate large intestine. Comp. Biochem. Physiol. 27, 505–517 (1968 a).

    Article  PubMed  CAS  Google Scholar 

  • Read, J.B., Burnstock, G.: Fluorescent histochemical studies of the mucosa of the vertebrate gastrointestinal tract. Histo-chemie 16, 324–332 (1968 b).

    CAS  Google Scholar 

  • Read, J.B., Burnstock, G.: Adrenergic innervation of the gut musculature in Vertebrates. Histochemie 17, 263–272 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Retzius, G.: Zur Kenntniss der Ganglienzellen des Sympathi-cus. Biol. Förendl. Verh. Biol. Ver. Stockholm 2, 16–25 (1889).

    Google Scholar 

  • Richardson, K.C.: Electronmicroscopic observations on Auerbach’s plexus in the rabbit, with special reference to the problem of smooth muscle innervation. Amer. J. Anat. 103, 99–135 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Richardson, K.C.: Electron microscopic identification of autonomic nerve endings. Nature (Lond.) 210, 756 (1966).

    Article  CAS  Google Scholar 

  • Richardson, K.C.: The fine structure of the albino rabbit iris, with special reference to the identification of adrenergic and cholinergic nerves and nerve endings in its intrinsic muscles. Amer. J. Anat. 114, 173–205 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Robertson, D.R.: The ultimobranchial body in Rana pipiens III. Sympathetic innervation of the secretory parenchyma. Z. Zellforsch. 78, 328–340 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Robertson, J.D.: The ultrastructure of cell membranes and their derivatives. Biochem. Soc. Symp. Cambridge 16, 3–43 (1959).

    CAS  Google Scholar 

  • Robinson, P.M.: Fine structure of the autonomic innervation of the smooth muscle of the toad lung. J. Anat. (Lond.) 99, 948–949 (1965).

    Google Scholar 

  • Robinson, P.M., MacLean, J.R., Burnstock, G.: Ultrastructural identification of non-adrenergic inhibitory nerve fibers. J. Pharmacol, exp. Ther. 179, 149–160 (1971).

    CAS  Google Scholar 

  • Rodriguez Echandia, E.X., Donoso, A.O., Pedroza, E.: A further contribution to the study of catecholamine flow in amphibian nerves. Acta physiol. lat.-am. 22, 161–165 (1972).

    PubMed  CAS  Google Scholar 

  • Rodriguez Echandia, E.L., Donoso, A.O., Zamora, A.: Cate-cholamine-transport in constricted nerve fibers of the toad. Currents in modern Biol. 3, 342–346 (1971).

    CAS  Google Scholar 

  • Rodriguez Echandia, E.X., Zamora, A., Piezzi, R.S.: Organelle transport in constricted nerve fibers of the toad Bufo arenarum Hensel. Z. Zellforsch. 104, 419–428 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Rogers, D.C., Burnstock, G.: The interstitial cell and its place in the concept of the autonomic ground plexus. J. comp. Neurol. 126, 255–284 (1966 a).

    Article  PubMed  CAS  Google Scholar 

  • Rogers, D.C., Burnstock, G.: Multiaxonal autonomic junctions in intestinal smooth muscle of the toad (Bufo marinus). J. comp. Neurol. 126, 625–652 (1966 b).

    Article  PubMed  CAS  Google Scholar 

  • Rosenbluth, J.: Subsurface cisterns and their relationship to the neuronal plasma membrane. J. Cell Biol. 13, 405–422 (1962a).

    Article  PubMed  CAS  Google Scholar 

  • Rosenbluth, J.: The fine structure of acoustic ganglia in the rat. J. Cell Biol. 12, 329–359 (1962b).

    Article  PubMed  CAS  Google Scholar 

  • Rosenbluth, J.: Constrast between osmium-fixed and permanganate fixed toad spinal ganglia. J. Cell Biol. 16, 143–157 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Rybak, B., Ruska, H., Ruska, C.: Ultrastructures nerveuses dans le ventricule du coeur de la Grenouille. Experientia (Basel) 22, 735–737 (1966).

    Article  Google Scholar 

  • Satchell, D.G., Burnstock, G.: Quantitative studies of the release of purine compounds following stimulation of non-adrenergic inhibitory nerves in the stomach. Biochem. Pharmacol. 20, 1694–1697 (1971).

    Article  CAS  Google Scholar 

  • Schnizer, W., Hoang, N.O., Brecht, K.: Transmitter in der Froschlunge. Pflügers Arch. 304, 271–283 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Schuller, J.: Über physiologische und pharmacologische Versuche am Rektum des Frosches. Naunyn-Schmiedebergs Arch. exp. Path. Pharmacol. 90, 196–241 (1921).

    Article  CAS  Google Scholar 

  • Semba, T., Hiraoka, T.: Motor responses of the stomach and small intestine caused by stimulation of the peripheral end of the splanchnic nerve, thoracic sympathetic trunk and spinal roots. Jap. J. Physiol. 7, 64–71 (1957).

    Article  CAS  Google Scholar 

  • Serebriakow, P.: Studien über den feineren Bau des Perizel-lulärapparates der Nervenzellen bei Wirbeltieren. I. Zur Morphologie der Perizellulärapparate in der Froschharnblase. Z. Zellforsch. 12, 1–33 (1930).

    Article  Google Scholar 

  • Shimada, K., Kobayasi, S.: Neural control of the pulmonary smooth muscle in the toad. Acta med. biol. (Niigata) 13, 297–303 (1966).

    CAS  Google Scholar 

  • Siegrist, G., de Ribeaupierre, F., DoLivo, M., Rouiller, C.: Les cellules chromaffines des ganglions cervicaux supérieurs du Rat. J. Microscopie (Paris), 5, 791–794 (1966).

    Google Scholar 

  • Siegrist, G., Dolivo, M., Dunant, Y., Foroglou-Kerameus, C., de Ribeaupierre, F., Rouiller, C.: Ultrastructure and function of the chromaffin cells in the superior cervical ganglion of the Rat. J. Ultrastruct. Res. 25, 381–407 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Siggins, G.R.: Evidence for reciprocal innervation of arterioles in the frog retrolingual membrane. Bibl. anat. (Basel) 9, 328–333 (1967).

    CAS  Google Scholar 

  • Siggins, G.R.: Comparative vasoconstrictor thresholds of arterioles in several thin membranes preparations. Proc. 14th Intern. Congr. Physiol. Sci. 7, 400 (1968).

    Google Scholar 

  • Siggins, G.R., Berman, H.J.: Quantitative measurements of the effects of pithing and anesthesis on an arteriolar nerve muscle preparation in the frog (Rana pipiens). Physiologist 8, 271 (1965).

    Google Scholar 

  • Siggins, G.R., Bloom, F.E.: Cytochemical and physiological effects of 6-hydroxydopamine on periarteriolar nerves of frogs. Circulat. Res. 27, 33–38 (1970).

    Google Scholar 

  • Siggins, G.R., Forman, D.S.: Degenerative effects of 6-amino-dopamine and 6-hydroxydopamine on peripheral adrenergic nerves. Z. Zeilforsch. 146, 339–349 (1973)

    Article  CAS  Google Scholar 

  • Siggins, G.R., Weitsen, H.A.: Cytochemical and physiological evidence for cholinergic, neurogenic vasodilatation of amphibian arterioles and precapillary sphincters. Microvascul. Res. 3, 308–322 (1971).

    Article  CAS  Google Scholar 

  • Singh, I.: Responses of frog’s stomach muscle produced by nervous stimulation presumably due to release of 5-HT. Arch. int. Pharcodyn. 141, 67–74 (1963).

    CAS  Google Scholar 

  • Singh, I.: Seasonal variations in the nature of neurotransmitters in a frog vagus-stomach muscle preparation. Arch. int. Physiol. 72, 843–851 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Singh, I., Sharma, S., Bhatnagar, O.P.: Absence of secretion of acetylcholine on stimulation of nerves in an unstriated muscle. Proc. Indian Acad. Sci. B 49, 129–135 (1959).

    Google Scholar 

  • Singh, I., Singh, S.I., Bhatnagar, O.P.: Source of acetylcholine in the frog’s heart on stimulation of the vagus nerve. Proc. Indian Acad. Sci. B 51, 52–56 (1960).

    Google Scholar 

  • Singh, I., Singh, S.I., Malhotra, C.L., Prasad, K.: Source of adrenaline and noradrenaline in the frog’s heart on stimulation of the sympathetic nerves. Proc. Indian Acad. Sci. B 52, 33–42 (1960).

    CAS  Google Scholar 

  • Smirnow, A.: Über Nervenendknauel in der Froschlunge. Anat. Anz. 3, 258–261 (1888).

    Google Scholar 

  • Smirnow, A.: Die Struktur der Nervenzellen im Sympathicus der Amphibien. Arch. mikr. Anat. 35, 407–424 (1890).

    Article  Google Scholar 

  • Smirnow, A.: Zur Kenntniss der Morphologie des sympathischen Ganglionzellen beim Frosche. Anat. Hefte, Abt. I, 14, 409–432 (1900).

    Article  Google Scholar 

  • Smirnow, A.: Ueber die Nervenendigungen in den Nieren der Saugetiere. Anat. Anz. 19, 347–359 (1901).

    Google Scholar 

  • Sneddon, J.D., Smythe, A., Satchell, D., Burnstock, G.: An investigation of the identity of the transmitter substance released by non-adrenergic, non-cholinergic excitatory nerves supplying the small intestine of some lower vertebrates. Comp. gen. Pharmacol. 4, 53–60 (1973).

    Article  Google Scholar 

  • Somlyo, A.P., Somlyo, A.V.: Vascular smooth muscle. Pharmacol. Rev. 20, 197–272 (1968).

    PubMed  CAS  Google Scholar 

  • Sotelo, C.: Permanence of postsynaptic specializations in the frog sympathetic ganglion cells after denervation. Exp. Brain Res. 6, 294–305 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Sotelo, C., Taxi, J.: On the axonal migration of catecholamines in constricted sciatic nerve of the rat. A radioau-tographic study. Z. Zellforsch. 138, 345–370 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Spanner: Untersuchungen über die Nerven der Niere von Rana agilis und Anguis fragilis mit der Methylenblaufärbung. Verh. Anat. Ges. Frankfurt 88–92 (1928).

    Google Scholar 

  • Staflova, J.: A comparative study of the adrenergic innervation of the iris and ciliary structures in 18 species in phylogenesis. J. Morph. 128, 387–402 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Stammer, A.: Die mikroskopische Struktur des Ggl. ciliare der Frösche. Acta Biol. Univ. Szeged 11, 127–133 (1965).

    Google Scholar 

  • Steinach, E.: Über die visceromotorischen Functionen der Hinterwurzeln und ihre tonische Hemmungswirkung der Medulla oblongata auf den Darm des Frosches. Pflügers Arch. ges. Physiol. 71, 523–554 (1898).

    Article  Google Scholar 

  • Steinach, E., Wiener, H.: Motorische Funktionen hinterer Spinalwurzeln. Pflügers Arch. ges. Physiol. 60, 593–622 (1895).

    Article  Google Scholar 

  • Stirling, W., MacDonald, J.F.: The minute structure of the palatine nerves of the frog and the termination of nerves in blood-vessels and glands. J. Anat. Physiol. 17, 293–307 (1883).

    Google Scholar 

  • Tandler, B., Hoppel, C.L.: Mitochondrion. New York-London: Academic Press 1972.

    Google Scholar 

  • Taxi, J.: Cellules de Schwann et “cellules interstitielles de Ca-jal” au niveau des plexus nerveux de la musculature intestinale du Cobaye: retour aux définitions. Arch. Anat. micr. Morph, exp. 41, 281–304 (1952).

    Google Scholar 

  • Taxi, J.: Sur la structure des travées du plexus d’Auerbach: confrontation des données fournies par le microscope ordinaire et par le microscope électronique. Ann. Sci. Nat., Zool., 12ème sér., I, 571–593 (1959).

    Google Scholar 

  • Taxi, J.: Etude de l’ultrastructure des zones synaptiques dans les ganglions sympathiques de la Grenouille. C.R. Acad. Sci. (Paris) 252, 174–176 (1961a).

    CAS  Google Scholar 

  • Taxi, J.: Etude au microscope électronique de ganglions sympathiques de Grenouille. Bull. Ass. Anat. 47th Meet. Naples, 786–794 (1961b).

    Google Scholar 

  • Taxi, J.: Etude au microscope électronique de synapses ganglionnaires chez quelques Vertébrés. IV Congr. Intern. Neuropath. 2, 197–203 (1962).

    Google Scholar 

  • Taxi, J.: Etude de certaines synapses interneuronales du système nerveux autonome. Acta neuroveg. (Wien) 26, 360–370 (1964).

    Article  CAS  Google Scholar 

  • Taxi, J.: Contribution à l’étude des connexions des neurones moteurs du système nerveux autonome. Ann. Sci. Nat., 12ème sér., 7, 413–674 (1965).

    Google Scholar 

  • Taxi, J.: Observations on the ultrastructure of the ganglionic neurons and synapses of the frog Rana esculenta L. In: The Neuron (H. Hydén, ed.), p. 221–254. Amsterdam-London-New York: Elsevier Publ. Co. 1967.

    Google Scholar 

  • Taxi, J.: Morphological and cytochemical studies on the synapses in the autonomic nervous system. In: Mechanisms of Synaptic Transmission (K. Akert and P.G. Waser, eds.), p. 5–20. Amsterdam-London-New York: Elsevier Publ. Co. 1969.

    Chapter  Google Scholar 

  • Taxi, J., Sotelo, C.: Le problème de la migration des catécholamines dans les neurones sympathiques. Rev. neurol. 127, 23–36 (1972).

    PubMed  CAS  Google Scholar 

  • Tennyson, V.M., Brzin, M., Duffy, P.E.: Electron microscopic cytochemistry and microgasometric analysis of Cholinesterase in the nervous system. In: Progress in Brain Research (A. Latjha and Ford, D.H., eds.), vol. 29, p. 41–61. Amsterdam-London-New York: Elsevier Publ. Co. 1967.

    Google Scholar 

  • Thaemert, I.C.: Ultrastructural interrelationships of nerve processes and smooth muscle cells in three dimensions. J. Cell Biol. 28, 37–49 (1966a).

    Article  PubMed  CAS  Google Scholar 

  • Thaemert, J.C.: Ultrastructure of cardiac muscle and nerve contiguities. J. Cell Biol. 29, 156–162 (1966 b).

    Article  PubMed  CAS  Google Scholar 

  • Tiegs, O.W.: Studies on plain muscle. Aust. J. exp. Biol. med. Sci. 1, 131–150(1924).

    Article  Google Scholar 

  • Tiegs, O.W.: The structure of the neurone junctions in sympathetic ganglia and in the ganglia of Auerbach’s plexus. Aust. J. exp. Biol. med. Sci. 3, 79–98 (1926).

    Google Scholar 

  • Tramezzani, J.H., Chicchio, S., Wassermann, G.F.: A technique for light and electron microscopic identification of adrenalin and noradrenalin-storing cells. J. Histochem. Cy-tochem. 12, 890–899 (1964).

    Article  CAS  Google Scholar 

  • Tsuchiya, S.: (in Japanese) Lung automatism in Japanese toad. J. Physiol. Soc. Jap. 21, 272–279 (1959).

    Google Scholar 

  • Tumanzew, D. J.: Zur Lehre über das Nervensystem des Herzens. Arch. mikr. Anat. 36, 483–506 (1890).

    Article  Google Scholar 

  • Uchizono, K.: On different types of synaptic vesicles in sympathetic ganglia of amphibia. Jap. J. Physiol. 14, 210–219 (1964).

    CAS  Google Scholar 

  • Uchizono, K., Ohsawa, K.: Morpho-physiological considerations on synaptic transmission in the amphibian sympathetic ganglion. Acta physiol. pol. 24, 205–214 (1973).

    PubMed  CAS  Google Scholar 

  • Uyeno, K.: The sympathetic innervation of the skin of the toad. J. Physiol. (Lond.) 56, 359–366 (1922).

    CAS  Google Scholar 

  • Verzar, F.: Untersuchungen über die Funktion der glatten Muskulatur der Lunge (Versuche an der Froschlunge). Helv. med. Acta, Pars Physiol., Suppl. V, 58–67 (1940).

    Google Scholar 

  • Vogt, M.: Über die Stoffliche Grundlage der Darmbewegungen und des Vagusriezes am Darm. Naunyn-Schmiedebergs Arch. exp. Path. Pharmakol. 206, 1–11 (1949).

    CAS  Google Scholar 

  • Voigt, R.: Ein Verfahren zur Beobachtung vasomotorischer Wirkungen an der Froschlunge und einige damit erzielte Ergebnisse. Naunyn-Schmiedebergs Arch. exp. Path. Pharmakol. 192, 170–188 (1939).

    Google Scholar 

  • Vorobiev, V.S.: On morphology of interneuronal connections in intramural ganglia of Amphibia Arkh. Anat. Gistol. Embr. 51, 71–75 (1966). [In Russian.]

    Google Scholar 

  • Watlington, C.O., Burke, P.K., Campbell, A.D., Hue, E.G.: Systemic effects of epinephrine in the frog. J. cell. comp. Physiol. 65, 337–354 (1965).

    Article  CAS  Google Scholar 

  • Watzka, M.: Vergleichende Untersuchungen über den ultimo-branchialen Körper. Z. mikr.-anat. Forsch. 34, 485–533 (1933).

    Google Scholar 

  • Welsh, J.H.: The quantitative distribution of 5-hydroxytrypta-mine in the nervous system, eyes and other organs of some Vertebrates. In: Comparative Neurochemistry (D. Richter, ed.). Oxford: Pergamon Press 1964.

    Google Scholar 

  • Whitear, M.: The vesicle population in frog skin nerves. J. Neurocytol. 3, 49–58 (1974a).

    Article  PubMed  CAS  Google Scholar 

  • Whitear, M.: The nerves in frog skin. J. Zool. 172, 503–529 (1974 b).

    Article  Google Scholar 

  • Wolfe, D.E., Potter, L.T., Richardson, K.C., Axelrod, J.: Localizing tritiated norepinephrine in sympathetic axons by electron microscope radioautography. Science 138, 440–442 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Wolff, M.: Ueber die Ehrlich’sche Methylenblaufärbung und über Lage und Bau einiger peripherer Nervenendigungen. Arch. Anat. Entw. Anat. Abt. Arch. Anat. Physiol. 155–188 (1902).

    Google Scholar 

  • Wong, W.C.: The myenteric plexus in the oesophagus of the toad (Bufo melanostictus). Acta anat. (Basel) 85, 52–62 (1973).

    Article  CAS  Google Scholar 

  • Wong, W.C., Sit, K.H., No, K.K.F., Chin, K.N.: The submucous plexus in the small intestine of the toad (Bufo melanostictus). Acta anat. (Basel) 79, 60–69 (1971a).

    Article  CAS  Google Scholar 

  • Wong, W.C., Sit, K.H., Ng, K.K.F., Chin, K.N.: A Cholinesterase study of the enteric plexuses in the toad (Bufo melanostictus). Acta anat. (Basel) 80, 82–90 (1971b).

    Article  CAS  Google Scholar 

  • Wood, M.E., Burnstock, G.: Innervation of the lung of the toad (Bufo marinus). I. Physiology and pharmacology. Comp. Biochem. Physiol. 22, 755–766 (1967).

    CAS  Google Scholar 

  • Woods, R.I.: Changes in content and interneuronal distribution of adrenaline in frog’s heart after cutting both vagosympathetic trunks. J. Physiol. (Lond.) 192, 48P–50P (1967).

    Google Scholar 

  • Woods, R.I.: The innervation of the frog’s heart. I. An examination of the autonomic postganglionic nerve fibers and a comparison of autonomic and sensory ganglion cells. Proc. roy. Soc. B 176, 43–54 (1970 a).

    Article  CAS  Google Scholar 

  • Woods, R.I.: The innervation of the frog’s heart. II. The effects of axotomy on the adrenalin content of the sympathetic nerve fibers. Proc. roy. Soc. B 176, 55–61 (1970b).

    Article  CAS  Google Scholar 

  • Woods, R.I.: The innervation of the frog’s heart. III. Electron microscopy of the autonomic nerve fibers and their vesicles. Proc. roy. Soc. B 176, 63–68 (1970c).

    Article  CAS  Google Scholar 

  • Yamagishi, S., Azuma, T.: Innervation of renal blood vessels of the toad. Jap. J. Physiol. 13, 399–412 (1963).

    Article  CAS  Google Scholar 

  • Yamamoto, T.: Some observations on the fine structure of the sympathetic ganglion of bullfrog. J. Cell Biol. 16, 159–170 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Yamauchi, A.: Innervation of the vertebrate heart as studied with the electron microscope. Arch. Histol. Jap. 31, 83–117 (1969).

    PubMed  CAS  Google Scholar 

  • Yuh, L.: On the innervation of the stomach of the Japanese frog. Jap. J. med. Sci. Biophys. 2, 25–33 (1931).

    Google Scholar 

  • Zweifach, B.W.: A note on the distribution of nerves to the small blood vessels in the mesentery of the frog. Anat. Rec., Suppl. 70, 104 (1938).

    Google Scholar 

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Taxi, J. (1976). Morphology of the Autonomic Nervous System. In: Frog Neurobiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66316-1_3

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