Summary
The effects of methohexitone, thiopentone, propanidid, ketamine and etomidate on regional cerebral blood flow (rCBF) were studied in 122 normal subjects under light halothane, nitrous oxide-anaesthesia (inspired halothane concentration of O,1–O,4 Vol.1). Cerebral blood flow was determined from the clearance of 133Xenon, following the intra-arterial injection of the isotope. Baseline values for rCBF under N2O/O2/halothane anaesthesia were 15% greater than values in conscious subjects. Autoregulation and CO2-responsiveness were preserved in the patients studied. A single intravenous injection of thiopentone (4 mg/kg) decreased rCBF by 45% when measured at 30 sec., 5 min and 10 min after termination of the intravenous injection. Propanidid (5 mg/kg) and methohexitone (1 mg/kg) reduced rCBF by 45% and 46% resp. 30 sec after the intravenous injection, by 24% and 22% resp. at 5 min and to 2% and 6,4% resp.(start of measurements at 10 min). Ketamine (2 mg/kg) reduced rCBF by 28% at 30 sec and by 15% at 5 min rCBF was reduced to baseline values by 10 min. The least decreasing effect on cerebral blood flow was caused by etomidate. The reduction of rCBF very rapidly subsided from 31% (start of measurements 30 sec after termination of i.v.-injection) through 19% (start of measurements at 3 min) to 1,8% and 0,9% (start of measurements at 5 and 10 min).
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Herrschaft, H., Schmidt, H., Gleim, F., Albus, G. (1975). The Response of Human Cerebral Blood Flow to Anaesthesia With Thiopentone, Methohexitone, Propanidid, Ketamine, and Etomidate. In: Penzholz, H., Brock, M., Hamer, J. (eds) Brain Hypoxia. Advances in Neurosurgery, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66239-3_18
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