Abstract
In patients with brain tumors regional cerebral blood flow (rCBF) is significantly diminished and the physiological regulation of rCBF to changes in arterial pCO2 and arterial blood pressure (autoregulation) may be impaired or lost focally or globally (2, 4). This tendency to a vasoparalysis has been attributed to tissue acidosis in edematous areas (1). As a result, acute arterial hypertension may be followed by deleterious clinical consequences by abnormally increasing tissue perfusion pressure as well as rCBF in areas with impaired vasomotor tone which leads to a break-through of pressure in the capillary system with further production of perifocal edema and increase of intracranial pressure (ICP). Dexamethasone was proved to substantially restore vasomotor regulation and increase rCBF in brain tumors (4, 6).
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© 1975 Springer-Verlag Berlin · Heidelberg
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Hadjidimos, A., Fischer, F., Reulen, H.J. (1975). Restitution of Vasomotor Autoregulation by Hypocapnia in Brain Tumors. In: Penzholz, H., Brock, M., Hamer, J. (eds) Brain Hypoxia. Advances in Neurosurgery, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66239-3_14
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DOI: https://doi.org/10.1007/978-3-642-66239-3_14
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