Modifiziertes Bonn- und Malmö-Protokoll: Behandlung erworbener Hemmkörper bei Nichthämophilen

  • Conference paper
29. Hämophilie-Symposion

Zusammenfassung

Eine Alloantikörperentwicklung gegen den Faktor VIII bei hämophilen Patienten, wie auch eine Antikörperentwicklung bei nichthämophilen Patienten führt zumeist zur vollkommenen Unterbindung der Faktor-VIII-Aktivität.

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Literatur

  1. Brackmann HH (1984) Induced immunotolerance in factor VIII inhibitor patients. Prog Clin Biol 150: 181–185

    CAS  Google Scholar 

  2. Brackmann HH, Formsen J (1977) Massive factor VIII infusion in hemophilic patients with factor VIII inhibitor. Lancet II; 933

    Article  Google Scholar 

  3. Brackmann HH, Oldenburg J, Schwaab R (1996) Immune tolerance for the treatment of factor VIII inhibitors-Twenty years’ `Bonn Protocol’ Vox Sang 70: 30–35

    Article  PubMed  Google Scholar 

  4. Green D, Lechner K (1981) A survey of 215 non-hemophilic patients with inhibitors to factor VIII. Thromb Haemost 45: 200–203

    PubMed  CAS  Google Scholar 

  5. Green D, Rademaker AW, Briet E (1993) A prospective, randomized trial of prednisone and cyclophosphamide in the treatment of patients with factor VIII autoantibodies Thromb Haemost 70 (5): 753–757

    CAS  Google Scholar 

  6. Kessler, CM (1991) Aquired factor VIII inhibitors in the nonhemophiliac: Historical perspectives, current therapies, and future approaches. Am J Med 91 (5 A): 1–48

    Article  Google Scholar 

  7. Knöbl P, Derfler K, Korninger L, Kapiotis S, Jager U, Maier-Dobersberger T, Horl W, Lechner K, Pabinger I (1995) Elimination of acquired factor VIII antibodies by extracorporal antibody-based immunadsorbtion (Ig-Therasorb). Thromb-Haemost. 74 (4): 1035–8

    PubMed  Google Scholar 

  8. Lottenberg R, Kentro TB, Kitchins CS (1987) Acquired Haemophilia: A natural history study of 16 patients with factor VIII inhibitor receiving little or no therapy. Arch Intern Med 147: 1077–1081

    Article  PubMed  CAS  Google Scholar 

  9. Ludlam CA, Morrison AE, Kessler C (1994) Treatment of Acquired Hemophilia. Seminars in Hematology 31 2 (4): 16–19

    Google Scholar 

  10. Morrison AE (1995) Acquired haemophilia and its management. British Journal of Haematology 89: 231–236

    Article  PubMed  CAS  Google Scholar 

  11. Nilsson IM, Berntorp E, Zettervall O (1988) Induction of immune tolerance in patients with hemophilia and antibodies to factor VIII by combined treatment with intravenous IgG, Cyclophosphamide, and Factor VIII N Eng J Med 318: 947–50

    CAS  Google Scholar 

  12. Nilsson IM, Jonsson S, Sundquist SB, Ahlberg A, Bergentz SE (1981) A procedure for removing high titer antibodies by extracorporal protein A sepharose adsorption in hemophilia. Blood 58: 38–42

    PubMed  CAS  Google Scholar 

  13. Nilsson IM, Freiburghaus C (1993) Treatment of patients with factor VII and IX inhibitors. Thromb Haemost 79: 56–9

    Google Scholar 

  14. Nilsson IM, Freiburghaus C (1995) Apheresis Inhibitors to Coagulation Factors Inhibitors to Coagulation Factors, Plenum Press, New York

    Google Scholar 

  15. Spero JA, Lewis JH & Hasaiba U (1981) Corticosteroid therapy for acquired FVIII-C inhibitors. British Journal of Haematology 48: 635–642

    Article  PubMed  CAS  Google Scholar 

  16. Zeitler H, Unkrig C, Brackmann H, Effenberger C, Hanfland D, Ko Y, Vetter H (1997) An immunmodulatory treatment of acquired hemophilia A with long-term-IgG-immunoadsorption, immunsupression, and antigensubstutiton-A modified Bonn-protocoll inducing immuntolerance ASH Meeting 39, (Abstract)

    Google Scholar 

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Hess, L. et al. (2000). Modifiziertes Bonn- und Malmö-Protokoll: Behandlung erworbener Hemmkörper bei Nichthämophilen . In: Scharrer, I., Schramm, W. (eds) 29. Hämophilie-Symposion. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59633-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-59633-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65929-7

  • Online ISBN: 978-3-642-59633-9

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