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Thermotolerance

  • Chapter
Thermoradiotherapy and Thermochemotherapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

  • 188 Accesses

Abstract

One of the most interesting aspects of thermal biology in the mammalian system is the response of heated cells to subsequent heat challenges. Mammalian cells, when exposed to a nonlethal heat shock, have the ability to acquire a transient resistance to one or more subsequent exposures at elevated temperatures. This phenomenon has been termed thermotolerance (Gerner and Schneider 1975; Henle and Leeper 1976). It has been studied most extensively in mammalian cells, largely because of the interest in the use of heat as an adjuvant technique for the treatment of some human cancers (Hahn 1982). The clinical application of hyperthermia, in general, involves multiple exposures of tumors to elevated temperatures. Clearly, it is important to know whether a past treatment affects the response of cells to a subsequent heat exposure. Therefore, the kinetics of induction and decay of thermo tolerance are of great interest. Furthermore, it is equally important to determine whether the radiation (or drug) sensitivity of cells surviving hyperthermic exposures has been modified. Many studies have examined the response of thermo-tolerant cells to drugs or x-irradiation (see Chaps. 4 and 5 in this volume).

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Authors and Affiliations

  1. Departments of Medical Physics and Radiation Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10021, USA

    P. Burgman PhD, A. Nussenzweig PhD & G. C. Li PhD

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  1. P. Burgman PhD
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  2. A. Nussenzweig PhD
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  3. G. C. Li PhD
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Editors and Affiliations

  1. Strahlentherapeutische Klinik, Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany

    M. Heinrich Seegenschmiedt

  2. Radiation Oncology Physics Division, Stanford University Medical Center, SUMC Room S-044, Stanford, CA, 94305, USA

    Peter Fessenden PhD (Professor Emeritus, Radiation Oncology) (Professor Emeritus, Radiation Oncology)

  3. Department of Clinical Oncology, Hammersmith Hospital, Ducane Road, London, W12 OHS, UK

    Clare C. Vernon MA, FRCR

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Burgman, P., Nussenzweig, A., Li, G.C. (1995). Thermotolerance. In: Seegenschmiedt, M.H., Fessenden, P., Vernon, C.C. (eds) Thermoradiotherapy and Thermochemotherapy. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57858-8_3

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  • DOI: https://doi.org/10.1007/978-3-642-57858-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63382-9

  • Online ISBN: 978-3-642-57858-8

  • eBook Packages: Springer Book Archive

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