Abstract
In the previous chapter I sketched several molar behaviors of cells during metazoan ontogeny. The purpose of the present chapter is to discuss an approach to relating the observed molar behaviors to the behaviors of the underlying coupled system of genes and products which regulate one anothers activities. We cannot in the near future expect to work through the control connections among so many components. However, we can hope to characterize a number of local, small scale properties of the organization of cellular control systems, such as specifying the typical number of molecular variables controlling any given process and specifying the ways variations in the regulating processes affect the controlled process.
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References
Asburner, M. (1971). Nature New Biology 230, 222.
“The Bacteriophage Lambda”. (1971). (A. D. Hershey, Ed.) Cold Spring Harbor Laboratory.
Berendes, H. D. (1965). Developmental Biology 11, 371.
Brenner, M. and Ames, B. N. (1971). In “Metabolic Pathways” 5 (H. J. Vogel, Ed.) p. 349. Academi Press, New York.
Bretscher, M. S. (1967). Nature 217, 509.
Britten, R. J. and Davidson, E. H. (1969). Science 165, 349.
Britten, R. J. and Davidson, E. H. (1971). J. Theoret. Biol. 32, 123.
Burstein, C., Cohn, M., Kepes, A. and Monod, J. (1965). Biochim. Biophys. Acta 95, 634.
Clever, U. (1966). Developmental Biology 14, 421.
De Crombrugghe, B., Chen, B., Anderson, W., Nissley, P., Gottesman, M., and Pastan, I. (1971). Nature New Biology 231, 139.
Echols, H. (1971). In “The Bacteriophage Lambda”. (A. D. Hershey, Ed.) p. 247, Cold Spring Harbor Laboratory.
Eisen, H. and Ptashne, M. (1971). In “The Bacteriophage Lambda”. (A. D. Hershey, Ed.) p. 239. Cold Spring Harbor Laboratory.
Gehring, W., Mindek, G. and Hadorn, E. (1968). J. Embryol. Morph. 20, 307.
Gehring, W. (1967). Developmental Biology 16, 438.
Glass, L. and Kauffman, S. A. (1972). J. Theoret. Biol. 34, 219.
Glass, L. and Kauffman, S. A. (1973). J. Theoret. Biol. 39, 103.
Hadorn, E. (1977). Developmental Biology 31, 424.
Heinemann, S. F. and Spieglemañ, W. G. (1970). Proc. Nat. Acad. Sci. U.S.A. 67, 1122.
Jacob, F. and Monod, J. (1963). “21st Symp. Soc. Study of Development and Growth”. Academic Press, London.
Kauffman, S. A. (1969a). J. Theoret. Biol. 22, 437.
Kauffman, S. A. (1969b). Nature 224, 177.
Kauffman, S. A. (1971). In “Current Topics in Developmental Biology” 6, p. 145. Academic Press, New York.
Kauffman, S. A. (1973). Science 181, 310.
Kauffman, S. K. (1974). J. Theoret. Biol. 44, 167.
Kumar, S., Calef, E. and Szybalski, W. (1970). Cold Spring Harbor Symp. Quant. Biol. 35, 331.
“Metabolic Pathways” 5. (1971). (H. J. Vogel, Ed.) Academic Press, New York.
Muller-Hill, B., Rikenberg, H. V. and Wallenfels, K. (1964). J. Mol. Biol. 10, 303.
Newman S. and Rice, S. (1971). Proc. Nat. Acad. Sci. U.S.A. 68, 92.
Neubauer, Z. and Calef, E. (1970). J. Mol. Biol. 51, 1.
Ohno, S. (1971). Nature 234, 134.
Ptashne, M. (1971). In “The Bacteriophage Lambda”. (A. D. Hershey, Ed.) Cold Spring Harbor Laboratory, p. 221.
Ptashne, M. (1967). Nature 214, 232.
Reichardt, L. and Kaiser, A. D. (1971). Proc. Nat. Acad. Sci. U.S.A. 68, 2185.
Riggs, A. D., Newby, R. F. and Bourgeois, S. J. (1970). J. Mol. Biol. 51, 303.
Roberts, J. W. (1969). Nature 224, 1168.
Szybalski, W., Bovre, K., Fiandt, M., Hayes, S., Hradecna, Z., Kumar, S., Lozeron, H.A., Nijkamp, H. J. J. and Stevens, W. F. (1970). Cold Spring Harbor Symp. Quant. Biol. 35, 341.
Thomas, R. (1971). In “The Bacteriophage Lambda”. (A. D. Hershey, Ed.) Cold Spring Harbor Laboratory, p. 211.
Tobler, H. (1966). J. Embryol. Exp. Morph. 16, 609.
Umbarger, H. E. (1969). Annual Review of Biochemistry 38, 323.
Vogel, R., McLellan, W., Hiroven, A. and Vogel, H. (1971). In “Metabolic Pathways” 5. (H. J. Vogel, Ed.) p. 463. Academic Press, New York.
Zubay, G. and Chambers, D. A. (1971). “Regulating the lac operaon” In “Metabolic Pathways” 5 (H. J. Vogel, Ed.) Academic Press, New York.
Zubay, G., Gielow, L. and Englasberg, E. (1971). Nature New Biology 233, 164.
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Kauffman, S.A. (1979). Assessing the Probable Regulatory Structures and Dynamics of the Metazoan Genome. In: Thomas, R. (eds) Kinetic Logic A Boolean Approach to the Analysis of Complex Regulatory Systems. Lecture Notes in Biomathematics, vol 29. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49321-8_3
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DOI: https://doi.org/10.1007/978-3-642-49321-8_3
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