Abstract
18F-FDG PET studies were shown to be quite sensitive to inflammation as well to a variety of benign diseases that induce focal increase in metabolism [1–3]. While in most countries PET imaging of these diseases are not reimbursed, it remains a potential alternative imaging modality for selected cases. FDG-PET remains a sensitive diagnostic modality for detection of infectious diseases and exploring sources of fever of unknown origin. In this chapter several diseases are presented, but also examples of identification and characterization of vascular plaques [4]. While 18F-FDG is being reported as a potential marker of plaque inflammatory process and therefore may help identify unstable plaques and be a predictor of cardiovascular events, alternative PET tracers are also being evaluated for better characterization of vascular plaques [4–6]. Another application domain of PET and therefore could potentially benefit from hybrid PET-MR is the assessment of neurodegenerative diseases and differentiation of diagnostic classification based on anatomical distribution of brain metabolic activity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Balink H, Collins J, Bruyn GA, Bruyn G, Gemmel F (2009) F-18 FDG PET/CT in the diagnosis of fever of unknown origin. Clin Nucl Med 34:862–868
Basu S, Kumar R, Alavi A (2010) PET and PET/CT imaging in infection and inflammation: its critical role in assessing complications related to therapeutic interventions in patients with cancer. Indian J Cancer 47:371–379
Yokota S, Kikuchi M, Nozawa T, Kizawa T, Kanetaka T, Kadota K, Miyamae T, Mori M (2012) Febrile responses in patients with pediatric rheumatic diseases. Nihon Rinsho Meneki Gakkai Kaishi 35:511–519
Temma T, Saji H (2012) Radiolabelled probes for imaging of atherosclerotic plaques. Am J Nucl Med Mol Imaging 2:432–447
Dweck MR, Chow MWL, Joshi NV, Williams MC, Jones C, Fletcher AM, Richardson H, White A, McKillop G, van Beek EJR, Boon NA, Rudd JHF, Newby DE (2012) Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology. J Am Coll Cardiol 59:1539–1548
Hermann S, Starsichova A, Waschkau B, Kuhlmann M, Wenning C, Schober O, Schäfers M (2012) Non-FDG imaging of atherosclerosis: will imaging of MMPs assess plaque vulnerability? J Nucl Cardiol 19:609–617
Arnaldi D, Morbelli S, Morrone E, Campus C, Nobili F (2012) Cognitive impairment in degenerative parkinsonisms: role of radionuclide brain imaging. Q J Nucl Med Mol Imaging 56:55–67
de Souza LC, Lehéricy S, Dubois B, Stella F, Sarazin M (2012) Neuroimaging in dementias. Curr Opin Psychiatry 25:473–479
Lopez OL, McDade E, Riverol M, Becker JT (2011) Evolution of the diagnostic criteria for degenerative and cognitive disorders. Curr Opin Neurol 24:532–541
Heiss W-D, Zimmermann-Meinzingen S (2012) PET imaging in the differential diagnosis of vascular dementia. J Neurol Sci 322:268–273
Lopez OL, McDade E, Riverol M, Becker JT (2011) Evolution of the diagnostic criteria for degenerative and cognitive disorders. Curr Opin Neurol 24:532–541
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Beer, A.J. et al. (2013). Benign, Degenerative and Inflammatory Diseases. In: Ratib, O., Schwaiger, M., Beyer, T. (eds) Atlas of PET/MR Imaging in Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-31292-2_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-31292-2_12
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-31291-5
Online ISBN: 978-3-642-31292-2
eBook Packages: MedicineMedicine (R0)