Abstract
In this paper, a closed-loop system to regulate plasma osmolality in patients with central diabetes insipidus is investigated. Using model identification techniques, we obtained a 3rd-order LTI model of the renal/body fluid system from an 11th-order nonlinear system. A Smith Predictor and an \({\mathcal H}_\infty\) controller were developed. The effectiveness of the controller to reject a step disturbance in the plasma osmolality is examined. This paper shows the potential use of control theory in the context of central diabetes insipidus.
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Zaarouri, K., Haidar, A., Boulet, B. (2010). Closed-Loop Control of Plasma Osmolality. In: Angeles, J., Boulet, B., Clark, J.J., Kövecses, J., Siddiqi, K. (eds) Brain, Body and Machine. Advances in Intelligent and Soft Computing, vol 83. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16259-6_17
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DOI: https://doi.org/10.1007/978-3-642-16259-6_17
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