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Cell Wall Targeted Antibiotics

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Prokaryotic Cell Wall Compounds

Abstract

The biosynthesis of murein occurs in three stages, which take place in (1) the cytoplasm forming muropeptide precursors, (2) the inner side of the cytoplasmic membrane involving the undecaprenyl-phosphate carrier lipid, and (3) the periplasm where the assembly of the macromolecule takes place. Antibiotics involved in the different steps of murein biosynthesis are described in this chapter.

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Acknowlegement

This work was supported by the EU (Intafar, LSHM-CT-2004-512138) and the Deutsche Forschungsgemeinschaft (Ha1011/11-1).

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  1. Department of Microbiology, University of Kaiserslautern, Paul Ehrlich Str., Geb. 23, 67663, Kaiserslautern, Germany

    Regine Hakenbeck

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  1. Regine Hakenbeck
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  2. Reinhold Brückner
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  3. Bernhard Henrich
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Correspondence to Regine Hakenbeck .

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  1. Inst. Mikrobiologie und, Universität Mainz, Becherweg 15, Mainz, 55099, Germany

    Helmut König

  2. Inst. Mikrobiologie und, Universität Mainz, Becherweg 15, Mainz, 55099, Germany

    Harald Claus

  3. Amity Institute of Microbial Sciences, Amity University Uttar Pradesh, Noida, 201303, India

    Ajit Varma

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Hakenbeck, R., Brückner, R., Henrich, B. (2010). Cell Wall Targeted Antibiotics. In: König, H., Claus, H., Varma, A. (eds) Prokaryotic Cell Wall Compounds. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05062-6_12

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