Abstract
Pediatric intramedullary spinal tumors (IMSTs) are generally uncommon, comprising 4–6% of all central nervous system (CNS) tumors and 35–40% of all intraspinal tumors in children [13, 21]. Of these, most are of glial origin. Astrocytomas are typically the most common, the majority being fibrillary. In children, the second most common IMSTs are gangliomas followed by ependymomas [13]. Ependymomas become more prevalent in older patients. Many other histological varieties, including germ cell tumors, primitive neu-roectodermal tumors, and intramedullary schwanno-mas, have also been identified in the spinal cord [10, 19]. Hemangioblastomas, typically found in patients with von-Hippel–Lindau disease, are exceedingly rare in the spinal cord in children and account for about 2% of all spinal cord tumors [3].
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References
Abbott R et al (1992) Osteoplastic laminotomy in children. Pediatr Neurosurg 18(3):153–156
Balmaceda C. (2000) Chemotherapy for intramedullary spinal cord tumors. J Neurooncol 47(3):293–307
Bostrom A et al (2008) Intramedullary hemangioblastomas: timing of surgery, microsurgical technique and follow-up in 23 patients. Eur Spine J 17(6):882–886
Chamberlain MC. (2002) Salvage chemotherapy for recurrent spinal cord ependymona. Cancer 95(5):997–1002
Clayton PE, Shalet SM. (1991) The evolution of spinal growth after irradiation. Clin Oncol (R Coll Radiol) 3(4):220–222
Cohen AR et al (1989) Malignant astrocytomas of the spinal cord. J Neurosurg 70(1):50–54
Constantini S et al (1996) Intramedullary spinal cord tumors in children under the age of 3 years. J Neurosurg 85(6):1036–1043
Constantini S et al (2000) Radical excision of intramedullary spinal cord tumors: surgical morbidity and long-term follow-up evaluation in 164 children and young adults. J Neurosurg 93(2 Suppl):183–193
Deletis V, Sala F. (2008) Intraoperative neurophysiological monitoring of the spinal cord during spinal cord and spine surgery: a review focus on the corticospinal tracts. Clin Neurophysiol 119(2):248–264
Deme S et al (1997) Primary intramedullary primitive neuroectodermal tumor of the spinal cord: case report and review of the literature. Neurosurgery 41(6):1417–1420
Duffner PK et al (1993) Postoperative chemotherapy and delayed radiation in children less than 3 years of age with malignant brain tumors. N Engl J Med 328(24):1725–1731
Garcia DM. (1985) Primary spinal cord tumors treated with surgery and postoperative irradiation. Int J Radiat Oncol Biol Phys 11(11):1933–1939
Jallo GI, Freed D, Epstein F. (2003) Intramedullary spinal cord tumors in children. Childs Nerv Syst 19(9):641–649
Kothbauer K, Deletis V, Epstein FJ. (1997) Intraoperative spinal cord monitoring for intramedullary surgery: an essential adjunct. Pediatr Neurosurg 26(5):247–254
Lonser RR et al (1998) Direct convective delivery of macro-molecules to the spinal cord. J Neurosurg 89(4):616–622
Lowe GM. (2000) Magnetic resonance imaging of intramed-ullary spinal cord tumors. J Neurooncol 47(3):195–210
Marsa GW et al (1975) Megavoltage irradiation in the treatment of gliomas of the brain and spinal cord. Cancer 36(5):1681–1689
McGirt MJ et al (2008) Incidence of spinal deformity after resection of intramedullary spinal cord tumors in children who underwent laminectomy compared with laminoplasty. J Neurosurg Pediatrics 1(1):57–62
Miller DC. (2000) Surgical pathology of intramedullary spinal cord neoplasms. J Neurooncol 47(3):189–194
Mora J et al (2007) Successful treatment of childhood intramedullary spinal cord astrocytomas with irinotecan and cisplatin. Neurooncol 9(1):39–46
Mottl H, Koutecky J. (1997)Treatment of spinal cord tumors in children. Med Pediatr Oncol 29(4):293–295
Muszynski CA, Constantini S, Epstein FJ. (1999) Intraspinal intramedullary neoplasms. In: Albright L, Pollack I, Adelson. (eds) Principles and practice of pediatric neuro-surgery. Thieme, New York, pp. 697–709
Nadkarni TD, Rekate HL. (1999) Pediatric intramedullary spinal cord tumors. Critical review of the literature. Childs Nerv Syst 15(1):17–28
Nakamura M et al (2008) Surgical treatment of intramedul-lary spinal cord tumors: prognosis and complications. Spinal Cord 46(4):282–286
Ng C et al (2007) Spinal cord glioblastoma multiforme induced by radiation after treatment for Hodgkin disease. Case report. J Neurosurg Spine 6(4):364–367
O'Sullivan C et al (1994) Spinal cord tumors in children: long-term results of combined surgical and radiation treatment. J Neurosurg 81(4):507–512
Rifkinson-Mann S, Wisoff JH, Epstein F. (1990) The association of hydrocephalus with intramedullary spinal cord tumors: a series of 25 patients. Neurosurgery 27(5):749–754; discussion 754
Sala F et al (2006) Motor evoked potential monitoring improves outcome after surgery for intramedullary spinal cord tumors: a historical control study. Neurosurgery 58(6):1129–1143; discussion 1129–1143
Sundaresan N, Gutierrez FA, Larsen MB. (1978) Radiation myelopathy in children. Ann Neurol 4(1):47–50
Yasuoka S, Peterson HA, MacCarty CS. (1982) Incidence of spinal column deformity after multilevel laminectomy in children and adults. J Neurosurg 57(4):441–445
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Myseros, J.S. (2010). Intramedullary Spinal Tumors in Children. In: Tonn, JC., Westphal, M., Rutka, J.T. (eds) Oncology of CNS Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02874-8_52
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