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Corticotropin-Releasing Factor (CRF) and its Role in the Central Nervous System

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Regulatory Peptides and Cognate Receptors

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 26))

Abstract

Corticotropin-releasing factor, commonly termed CRF, was originally described as a neurohumoral factor in the hypothalamus-pituitary system that regulates the synthesis and secretion of adrenocorticotropic hormone (ACTH). Since the complete peptide sequence of ovine CRF was reported by Vale et al. in 1981, it has also been termed corticotropin-releasing hormone or CRH. In all the animal species investigated so far (sheep, rats, humans, cattle, goats) CRF has been shown to contain 41 amino acids, and to share structural homology with some other peptides including urotensin-I and sauvagine (Chang et al. 1993; Vaughan et al. 1995). A large number of reports suggest that CRF in the hypothalamus plays a major role in the responses of the body to stress and is involved in affective disorders (as reviewed by Koob et al. 1993; De Souza 1995; Heinrichs et al. 1995; Gray and Bingaman 1996; Heit et al. 1997).

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Authors and Affiliations

  1. Laboratory for Memory and Learning, Brain Science Institute, Institute of Physical and Chemical Research, RIKEN, Wako, Saitama, 351-0198, Japan

    Masao Ito

  2. Department of Physiology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku, Tokyo, 162-8666, Japan

    Mariko Miyata

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  1. Masao Ito
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  1. Institut für Zellbiochemie und Klinische Neurobiologie, Universität Hamburg, Martinistr. 52, D-20246, Hamburg, Germany

    Dietmar Richter

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Ito, M., Miyata, M. (1999). Corticotropin-Releasing Factor (CRF) and its Role in the Central Nervous System. In: Richter, D. (eds) Regulatory Peptides and Cognate Receptors. Results and Problems in Cell Differentiation, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49421-8_3

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  • DOI: https://doi.org/10.1007/978-3-540-49421-8_3

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