Abstract
During the ontogeny of Drosophila larval salivary gland cells, nuclear DNA is endoreduplicated and organized into polytene chromosomes. All DNA sequences are not reduplicated to the same extent. Satellite DNA’s, which are concentrated in the centromeric heterochromatin of diploid cells, are coalesced in the chromocenter of polytene cells (Gall et al. 1971) and selectively underreplicated (Dickson et al. 1971; Gall et al. 1971). In D. virilis, for instance, three satellites comprise about 45% of the diploid DNA (Gall et al. 1971; Blumenfeld and Forrest 1972) but less than 1% of polytene salivary gland cell DNA (Gall et al. 1971). Underreplication presumably involves specific interactions between chromosomal proteins and satellite DNA’s, or nucleotide sequences lying near satellites. Proteins that can be correlated with satellites migth be involved with these interactions. With this in mind, consider that the underreplication of satellite DNA is correlated with the decreased phosphorylation of Hl histones (Blumenfeld et al. 1978).
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Blumenfeld, M., Billings, P.C., Orf, J.W., Pan, C.G., Palmer, D.K., Snyder, L.A. (1980). Differential Histone Phosphorylation During Drosophila Development. In: McKinnell, R.G., DiBerardino, M.A., Blumenfeld, M., Bergad, R.D. (eds) Differentiation and Neoplasia. Results and Problems in Cell Differentiation, vol 11. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-38267-6_5
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DOI: https://doi.org/10.1007/978-3-540-38267-6_5
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