Abstract
A 3D heart model is proposed to simulate the effect of bundle branch blocks in human heart. This model consists of the ventricle model with the electrophysiological approximation of the cells. The computational approach to cardiac cells is based on the electrophysiological model of the human ventricular myocytes proposed by ten Tusscher et al. (2004). The 3D geometry of human heart tissue is discretized to a finite element mesh system for the simulation of electric wave propagation using a monodomain method. Purkinje fibers in ventricles are modeled based on an anatomical structure with simplified model of electric conduction. Using the proposed human heart model we simulated the electrophysiological effects of BBB (bundle branch block) in cardiac tissue. Computational results showed that the BBB induces the changes of electric wave conduction pattern and pseudo-ECG signal compared with normal heart.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
A.V. Panfilov, A.V. Holden, 1993, “Computer simulation of re-entry sources in myocardium in two and three dimensions.” J Theor Biol. 161;271–285.
J.M. Rogers, A.D. McCulloch, 1994, “A collocation-Galerkin finite element model of cardiac action potential propagation.” IEEE Trans Biomed Eng. 41:743–757.
R.L. WINSLOW, D.F. SCOLLAN, A. HOLMES, C.K. Yung, J. Zhang, M.S. JAFRI, 2000, “Electrophysiological modeling of cardiac ventricular function: from cell to organ.” Annu Rev Biomed Eng 2, 119–155.
P.J. Hunter, A.J. Pullan, B.H. Smaill, 2003, “Modeling total heart function.” Annu Rev Biomed Eng. 5:147–77.
K.H. Ten Tusscher, D. Noble, P.J. Noble, A.V. Panfilov 2003 “A model for human ventricular tissue.” Am J Physiol Heart Circ Physiol. Dec 4.
Omer Berenfeld, Jose Jalife, 1998, “Purkinje-Muscle Reentry as a Mechanism of Polymorphic Ventricular Arrhythmias in a 3_Dimensional Model of the Ventricles.” American Heart Association, 82,1063–1067
http://www.cellml.org
Author information
Authors and Affiliations
Corresponding author
Editor information
Rights and permissions
Copyright information
© 2007 International Federation for Medical and Biological Engineering
About this paper
Cite this paper
Kwon, S.S., Shim, E.B., Leem, C.H. (2007). Computational analysis of the effects of bundle branch blocks in human heart using cardiac cell models. In: Magjarevic, R., Nagel, J.H. (eds) World Congress on Medical Physics and Biomedical Engineering 2006. IFMBE Proceedings, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-36841-0_33
Download citation
DOI: https://doi.org/10.1007/978-3-540-36841-0_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-36839-7
Online ISBN: 978-3-540-36841-0
eBook Packages: EngineeringEngineering (R0)