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Early Postnatal Development of Somastostatinergic Systems in Brainstem Respiratory Network

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The Plastic Brain

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1015))

Abstract

Somatostatin is a peptide able to stop breathing, acting in the neural network that generates and control the respiratory rhythm. In this chapter, we present data on the early postnatal development of somatostatinergic systems in the mouse brainstem and summarize evidence for their influence on the generation and control of the respiratory rhythm.

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Abbreviations

7:

Facial nucleus

10:

Dorsal motor nucleus of vagus

12 or XII:

Hypoglossal nucleus

Amb:

Ambiguus nucleus

AVC:

Anteroventral cochlear nucleus

BötC:

Bötzinger nucleus

CIC:

Central nucleus inferior colliculus

CPG:

Central pattern generator

Cu:

Cuneate nucleus

cVRG:

Caudal ventral respiratory group

DMTg:

Dorsomedial tegmental area

DPGi:

Dorsal paragigantocellular nucleus

DRC:

Dorsal respiratory column

E:

Embryonic

ECIC:

External cortex of the inferior colliculus

ECu:

External cuneate nucleus

Gi:

Gigantocellular reticular nucleus

GiV:

Gigantocellular reticular nucleus, ventral part

GrC:

Granular layer of the cochlear nucleus

IO:

Inferior olive

IRt:

Intermediate reticular nucleus

KF:

Kölliker-Fuse nucleus

LC:

Locus coeruleus

LPBE:

Lateral parabrachial nucleus, external part

LPBS:

Lateral parabrachial nucleus, superior part

LPGi:

Lateral paragigantocellular nucleus

LRt:

Lateral reticular nucleus

LVPO:

Lateral ventral periolivary nucleus

MdD:

Medullary reticular nucleus, dorsal part

ml:

Medial lemniscus

Mo5:

Motor trigeminal nucleus

MPB:

Medial parabrachial nucleus

MVe:

Medial vestibular nucleus

MVeMC:

Medial vestibular nucleus, mediocaudal part

MVePC:

Medial vestibular nucleus, parvicellular part

MVPO:

Medioventral periolivary nucleus

NK1R:

Neurokinin 1 receptor

NTS:

Nucleus of solitary tract (labeled Sol in figures)

P:

Postnatal

P7:

Perifacial zone

PCRtA:

Parvicellular reticular formation

Pert:

Parvicellular reticular nucleus

pFRG:

Parafacial respiratory group

PGi:

Paragigantocellular nucleus

ppy:

Peripyramidal nucleus

preBötC:

PreBötzinger complex

PRG:

Pontine respiratory group

py:

Pyramidal tract

RIA:

Radioimmunoassay

RTN:

Retrotrapezoid nucleus

RtTg:

Reticulotegmental nucleus of the pons

RVL:

Rostroventrolateral reticular nucleus

rVRG:

Rostral ventral respiratory group

scp:

Superior cerebelar peduncule

SIDS:

Sudden infant death syndrome

Sol DL:

Dorsolateral sub nucleus of NTS

Sol V:

Ventral NTS

Sol VL:

Ventrolateral sub nucleus of NTS

sp5:

Spinal trigeminal tract

SpVe:

Spinal vestibular nucleus

SST:

Somatostatin

Su5:

Supratrigeminal nucleus

VCP:

Ventral cochlear nucleus, posterior part

VRC:

Ventral respiratory column

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Acknowledgements

This article is dedicated to the memory of Dr. Silvia Araneda. This work was funded by grants from the National Fund for Scientific and Technological Development (FONDECYT # 1000025) and Research Division of the University of Santiago (DICYT # 029843ILL # 020643LLR). JL Troc-Gajardo is a PhD candidate at the PhD Program in Neuroscience, Universidad de Santiago de Chile, and she was financed by Programa de Formación de Capital Humano Avanzado # 21130284, Comisión Nacional de Investigación Científica y Tecnológica, Chile.

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Authors and Affiliations

  1. Laboratorio de Sistemas Neurales, Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Postal Code 9170022, Santiago, Chile

    Isabel Llona PhD, Paula Farías PhD & Jennifer L. Troc-Gajardo

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  1. Isabel Llona PhD
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  2. Paula Farías PhD
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  3. Jennifer L. Troc-Gajardo
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Correspondence to Isabel Llona PhD .

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  1. Pontificia Universidad Católica de Chile, Santiago, Chile

    Rommy von Bernhardi

  2. Universidad de Santiago de Chile, Santiago, Chile

    Jaime Eugenín

  3. University of Miami, Miami, USA

    Kenneth J Muller

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Llona, I., Farías, P., Troc-Gajardo, J.L. (2017). Early Postnatal Development of Somastostatinergic Systems in Brainstem Respiratory Network. In: von Bernhardi, R., Eugenín, J., Muller, K. (eds) The Plastic Brain. Advances in Experimental Medicine and Biology, vol 1015. Springer, Cham. https://doi.org/10.1007/978-3-319-62817-2_8

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