Endothelial Proliferation

Armstrong, Carol L.

doi:10.1007/978-3-319-56782-2_106-2

Carol L. Armstrong⁴

671 Accesses

Synonyms

Vascular endothelial proliferation

Definition

Endothelial proliferation is an increase in vascular endothelial cells needed for the growth of new or existing blood vessels. It is stimulated by solid tumors that need to generate blood vessels to continue growth. It contributes to angiogenesis in tumor formation (Louis and Cavenee 2005) and results from overexpression of vascular endothelial growth factor (VEGF). Endothelial proliferation is one of the characteristics of malignancy in gliomas as defined by the World Health Organization’s primary central nervous system tumor grading system (Kleihues et al. 1993). Endothelial proliferation is associated with breakdown in the blood-brain barrier (Kracht et al. 2004). It is a feature of malignancy that indicates poor prognosis but is considered in combination with other features such as genetic markers that predict tumor growth.

References and Readings

Kleihues, P., Burger, P. C., & Scheithauer, B. W. (1993). The new WHO classification of brain tumours. Brain Pathology, 3(3), 255–268.
Article PubMed Google Scholar
Kracht, L. W., Miletic, H., Busch, S., Jacobs, A. H., Voges, J., Hoevels, M., et al. (2004). Delineation of brain tumor extent with [¹¹C]L-methionine positron emission tomography: Local comparison with stereotactic histopathology. Clinical Cancer Research, 10, 7163–7170.
Article PubMed Google Scholar
Louis, D. N., & Cavenee, W. K. (2005). Molecular biology of central nervous system tumors. Boston: Massachusetts General Hospital, MGH Neurosurgical Service, Brain Tumor Center. http://brain.mgh.harvard.edu/MolecularGenetics.htm.
Google Scholar

Download references

Author information

Authors and Affiliations

Child and Adolescent Psychiatry and Behavioral Sciences, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Carol L. Armstrong

Authors

Carol L. Armstrong
View author publications
You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carol L. Armstrong .

Editor information

Editors and Affiliations

Richmond, Virgin Islands, USA
Jeffrey Kreutzer
Kessler Foundation , West Orange, New Jersey, USA
John DeLuca
Suite 200 , Wynnewood, Pennsylvania, USA
Bruce Caplan

Rights and permissions

Reprints and permissions

Copyright information

About this entry

Cite this entry

Armstrong, C.L. (2018). Endothelial Proliferation. In: Kreutzer, J., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-56782-2_106-2

Download citation

DOI: https://doi.org/10.1007/978-3-319-56782-2_106-2
Received: 15 April 2016
Accepted: 03 November 2017
Published: 20 November 2017
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-56782-2
Online ISBN: 978-3-319-56782-2
eBook Packages: Springer Reference Behavioral Science and PsychologyReference Module Humanities and Social SciencesReference Module Business, Economics and Social Sciences

Publish with us

Policies and ethics