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Linkage Analysis

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Encyclopedia of Animal Cognition and Behavior

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Introduction

Linkage analysis is a well-established statistical method in the field of reverse genetics, where in the predisposing gene(s) causing a heritable trait is/are identified.

Description

Basic Concepts

Linkage analysis being a statistical method requires understanding of some basic terms such as recombination fraction, likelihood functions, maximum likelihood estimation, and odds ratios.

Genetic Recombination, Linked Genes, Genetic Distance, and Physical Distance

Genetic recombination is a biological phenomenon occurring in the parental gametes during the process of meiosis before eggs and sperms are formed. This phenomenon leads to exchange of chromosome material between homologous chromosomes via a crossover event with the crossover location thought to be determined by chance. Thus, each child inherits a unique set of recombinant chromosomes of their grandparents.

Genes located close enough to each other on a chromosome and whose expected crossover rate within the genetic...

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References

  • Cantor, R. M. (2013). Analysis of Genetic Linkage. In D L Rimoin, R E Pyeritz, B R. Korf (Eds.), Emery and Rimoin’s Principles and Practice of Medical Genetics (pp. 1–8). Academic Press, Elsevier Ltd. https://doi.org/10.1016/B978-0-12-801238-3.05482-9

  • Griffiths, A. J. F., et al. (2000). An introduction to genetic analysis (7th ed.). New York: WH Freeman & Co.

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  • Morton, N. E. (1955). Sequential tests for the detection of linkage. Am. J. Hum. Genet., 7, 277–318.

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  • Nussbaum, R. L., McInnes, R. R., & Willard, H. F. (2007). Human gene map** and disease gene identification. In Thompson and Thompson Genetics in Medicine 7th edition. (pp. 207–321). Saunders Elsevier Ltd., Philadelphia. ISBN: 9781416030805.

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  • Vogel, F., & Motulsky, A. G. (1997). Human genetics. Problems and approaches (3rd ed.). Heidelberg–New York: Springer Verlag.

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Author information

Authors and Affiliations

  1. Department of Anatomy, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan, India

    Kishore Sesham & Hare Krishna

Authors
  1. Kishore Sesham
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  2. Hare Krishna
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Editor information

Editors and Affiliations

  1. Department of Psychology, Oakland University, Rochester, MI, USA

    Jennifer Vonk

  2. Department of Psychology, Oakland University, Rochester, MI, USA

    Todd K. Shackelford

Section Editor information

  1. Penn State Worthington Scranton, Scranton, USA

    Douglas Sellers

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Sesham, K., Krishna, H. (2022). Linkage Analysis. In: Vonk, J., Shackelford, T.K. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. https://doi.org/10.1007/978-3-319-55065-7_494

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