General Introduction
The conditioned place preference (CPP) procedure has been widely used in pharmacology, learning, and behavioral neuroscience. Its most common, but not exclusive, application has been in studying the rewarding and/or aversive properties of drugs and as a screening tool for drug abuse potential (e.g., Bardo and Bevins 2000; Tzschentke 1998). Although there are many methodological differences, the general CPP procedure consists of presenting a rewarding or aversive stimulus in the presence of one distinct chamber on one day and a neutral stimulus (e.g., vehicle) in another distinct chamber on alternating days. After several conditioning days, subjects receive a choice test that involves access to the entire apparatus without the presence of the stimuli. A CPP is established if subjects spend significantly more time in the compartment paired with the rewarding or aversive stimulus. If subjects spend less time in a compartment paired with a stimulus, they may be...
References
Astur, R. S., Carew, A. W., & Deaton, B. E. (2014). Conditioned place preferences in humans using virtual reality. Behavioural Brain Research, 267, 173–177.
Bardo, M. T., & Bevins, R. A. (2000). Conditioned place preference: What does it add to our preclinical understanding of drug reward? Psychopharmacology, 153(1), 31–43.
Braida, D., Iosuè, S., Pegorini, S., & Sala, M. (2005). 3,4 Methylenedioxymethamphetamine-induced conditioned place preference (CPP) is mediated by the endocannabinoid system. Pharmacology Research, 51, 177–182.
Calcagnetti, D. J., & Schechter, M. D. (1992). Place conditioning reveals the rewarding aspect of social interaction in juvenile rats. Physiology & Behavior, 51(4), 667–672.
Childs, E., & de Wit, H. (2013). Contextual conditioning enhances the psychostimulant and incentive properties of d-amphetamine in humans. Addiction Biology, 18(6), 985–992.
Cunningham, C. L., & Noble, D. (1992). Conditioned activation induced by ethanol: Role in sensitization and conditioned place preference. Pharmacology Biochemistry and Behavior, 43(1), 307–313.
Daza-Losada, M., Ribeiro Do Couto, B., Manzanedo, C., Aguilar, M. A., Rodríguez-Arias, M., & Miñarro, J. (2007). Rewarding effects and reinstatement of MDMA-induced CPP in adolescent mice. Neuropsychopharmacology, 32(8), 1750–1759.
Duarte, R. B., Patrono, E., Borges, A. C., Tomaz, C., Ventura, R., Gasbarri, A., Puglisi-Allegra, S., & Barros, M. (2015). High versus low fat/sugar food affects the behavioral, but not the cortisol response of marmoset monkeys in a conditioned-place preference task. Physiology & Behavior, 139, 442–8.
Fidler, T. L., Bakner, L., & Cunningham, C. L. (2004). Conditioned place aversion induced by intragastric administration of ethanol in rats. Pharmacology Biochemistry and Behavior, 77(4), 731–743.
Hempel, B. J., Wakeford, A. G., Clasen, M. M., Friar, M. A., & Riley, A. L. (2016). Delta-9-tetrahydrocannabinol (THC) history fails to affect THC’s ability to induce place preferences in rats. Pharmacology Biochemistry and Behavior, 144, 1–6.
Karami, M., & Zarrindast, M. R. (2008). Morphine sex-dependently induced place conditioning in adult Wistar rats. European Journal of Pharmacology, 582(1), 78–87.
Le Foll, B., & Goldberg, S. R. (2005). Nicotine induces conditioned place preferences over a large range of doses in rats. Psychopharmacology, 178(4), 481–492.
Lett, B. T., Grant, V. L., Byrne, M. J., & Koh, M. T. (2000). Pairings of a distinctive chamber with the aftereffect of wheel running produce conditioned place preference. Appetite, 34(1), 87–94.
Levens, N., & Akins, C. K. (2001). Cocaine induces conditioned place preference and increases locomotor activity in male Japanese quail. Pharmacology Biochemistry and Behavior, 68, 71–80.
Mace, D. D., Kraemer, P. J., & Akins, C. K. (1997). Conditioned place preference in 12-day-old Japanese quail. Developmental Psychobiology, 31(4), 245–254.
Masaki, T., & Nakajima, S. (2008). Forward conditioning with wheel running causes place aversion in rats. Behavioural Processes, 79(1), 43–47.
Mirbaha, H., Tabaeizadeh, M., Shaterian-Mohammadi, H., Tahsili-Fahadan, P., & Dehpour, A. R. (2009). Estrogen pretreatment modulates morphine-induced conditioned place preference in ovariectomized mice. Pharmacology Biochemistry and Behavior, 92(3), 399–403.
Napier, T. C., Herrold, A. A., & de Wit, H. (2013). Using conditioned place preference to identify relapse prevention medications. Neuroscience & Biobehavioral Reviews, 37, 2081–2086.
Neisewander, J. L., Pierce, R. C., & Bardo, M. T. (1990). Naloxone enhances the expression of morphine-induced conditioned place preference. Psychopharmacology, 100(2), 201–205.
Paredes, R. G. (2009). Evaluating the neurobiology of sexual reward. ILAR Journal, 50(1), 15–27.
Prus, A. J., James, J. R., & Rosecrans, J. A. (2009). Conditioned place preference. In Methods of behavior analysis in neuroscience. Boca Raton: Taylor & Francis Group, LLC.
Russo, S. J., Festa, E. D., Fabian, S. J., Gazi, F. M., Kraish, M., Jenab, S., & Quinones-Jenab, V. (2003). Gonadal hormones differentially modulate cocaine-induced conditioned place preference in male and female rats. Neuroscience, 120(2), 523–533.
Schindler, C. W., Bross, J. G., & Thorndike, E. B. (2002). Gender differences in the behavioral effects of methamphetamine. European Journal of Pharmacology, 442(3), 231–235.
Spyraki, C., Fibiger, H. C., & Phillips, A. G. (1982). Attenuation by haloperidol of place preference conditioning using food reinforcement. Psychopharmacology, 77(4), 379–382.
Tenk, C. M., Wilson, H., Zhang, Q., Pitchers, K. K., & Coolen, L. M. (2009). Sexual reward in male rats: Effects of sexual experience on conditioned place preferences associated with ejaculation and intromissions. Hormones and Behavior, 55, 93–97.
Torres, O. V., Walker, E. M., Beas, B. S., & O’Dell, L. E. (2014). Female rats display enhanced rewarding effects of ethanol that are hormone dependent. Alcoholism: Clinical and Experimental Research, 38(1), 108–115.
Tzschentke, T. M. (1998). Measuring reward with the conditioned place preference paradigm: A comprehensive review of drug effects, recent progress and new issues. Progress in Neurobiology, 56(6), 613–672.
Vastola, B. J., Douglas, L. A., Varlinskaya, E. I., & Spear, L. P. (2002). Nicotine-induced conditioned place preference in adolescent and adult rats. Physiology & Behavior, 77(1), 107–114.
Zakharova, E., Leoni, G., Kichko, I., & Izenwasser, S. (2009). Differential effects of methamphetamine and cocaine on conditioned place preference and locomotor activity in adult and adolescent male rats. Behavioural Brain Research, 198(1), 45–50.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this entry
Cite this entry
Akins, C.K., Eaton, S.E., Bolin, B.L. (2022). Conditioned Place Preference. In: Vonk, J., Shackelford, T.K. (eds) Encyclopedia of Animal Cognition and Behavior. Springer, Cham. https://doi.org/10.1007/978-3-319-55065-7_1303
Download citation
DOI: https://doi.org/10.1007/978-3-319-55065-7_1303
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-55064-0
Online ISBN: 978-3-319-55065-7
eBook Packages: Behavioral Science and PsychologyReference Module Humanities and Social SciencesReference Module Business, Economics and Social Sciences