Abstract
Lipids are the major components of biological membranes, playing a role in cell architecture and integrity but also in signaling. Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are signaling lipids known to exert pleiotropic effects in various cell types, including during development and disease. They have also been described as potent mediators of stem cell behavior. In this chapter, we review the current knowledge on these major signaling lipids by focusing on pluripotent stem cells. Their impact on pluripotency will be described.
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Abbreviations
- ABC:
-
ATP-binding cassette
- ATX:
-
Autotaxin
- ENNP2:
-
Ectonucleotide pyrophosphatase phosphodiesterase 2
- ERK:
-
Extracellular signal-regulated kinase
- HDAC:
-
Histone deacetylase
- hESC:
-
Human embryonic stem cell
- iPSC:
-
Induced pluripotent stem cell
- JNK:
-
c-jun N-terminal kinase
- LPA:
-
Lysphosphatidic acid
- MAP:
-
Mitogen-activated protein
- mESC:
-
Mouse embryonic stem cell
- PDGF:
-
Platelet-derived growth factor
- PI3K:
-
Phosphoinositide 3-kinase
- PPAR:
-
Peroxisome proliferator-activated receptor
- S1P:
-
Sphingosine-1-phosphate
- SPhK:
-
Sphingosine kinase
- TRAF2:
-
TNF receptor-associated factor 2
- VEGF:
-
Vascular endothelial growth factor
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Acknowledgements
This work was supported by an Australian Postgraduate Award Scholarship (GL), an Australian Research Council (ARC) Future Fellowship (AP, FT140100047), the University of Melbourne and Operational Infrastructure Support from the Victorian Government.
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Lidgerwood, G.E., Pébay, A. (2017). Lysophosphatidic Acid and Sphingosine-1-Phosphate in Pluripotent Stem Cells. In: Pébay, A., Wong, R. (eds) Lipidomics of Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-49343-5_1
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DOI: https://doi.org/10.1007/978-3-319-49343-5_1
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