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The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline

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Translational Toxicology

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

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Abstract

Since presentation of our view of translational developmental toxicology in 2013, numerous investigations from a wide range of approaches have added to the evidence underlying our core premise; namely that as the potential adverse developmental effects from a range of exposures are progressively defined, preventative or mitigative therapies can be conceived, assessed and ethically implemented. The spectrum of studies reported in recent years span a wide range of exposure categories and various developmental outcomes ranging from molecular and cellular to the organismal level up to and including human behavior. Since human exposures to chemicals, physical agents and social factors are inevitable, the human fetus is subject to effects that can have lifelong consequences. In order to apply the translational concept to developmental toxicology, established or potential therapeutic obstetrical, neonatal, childhood and adolescent interventions will be required. Those that undergo testing during developmentally sensitive intervals will likely derive from generally-regarded-as-safe (GRAS) or well-established/repurposed pharmaceutical options. Ultimately if we are to translate environmental health discoveries into safe and effective interventions, we must assert and characterize valid, applicable therapies such as GRAS treatments and eventually “ethical pharmaceuticals” for the protective care of these highly vulnerable young people. We can create a safe and efficacious environmental health portfolio of interventional options to improve human health that include both reduction/avoidance of exposure and specific preventative/mitigative/restorative therapeutics. In this chapter we will broadly update new insights that have been gained over the last 2 years regarding the progress of translational developmental toxicology toward becoming a therapeutic discipline.

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Authors and Affiliations

  1. Therapeutic Science & Strategy Unit, Quintiles, Inc., 5927 S. Miami Blvd., Morrisville, NC, 27560, USA

    Claude L. Hughes

  2. Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA

    Claude L. Hughes

  3. Department of Mathematics, North Carolina State University, Raleigh, NC, USA

    Claude L. Hughes

  4. Michael Waters Consulting, 210 N. Wake Street, Hillsborough, NC, USA

    Michael D. Waters Ph.D.

  5. Science and Strategy, Integrated Laboratory Systems, Inc. (ILS), Suite 800, 601 Keystone Park Drive, Research Triangle Park, Durham, NC, 27713, USA

    David Allen Ph.D.

  6. Research Fellow, African Presidential Center, Boston University, Boston, MA, 02215, USA

    Iyabo Obasanjo D.V.M., Ph.D.

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  1. Claude L. Hughes
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Correspondence to Claude L. Hughes .

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  1. Therapeutic Science & Strategy Unit, Quintiles Inc., MORRISVILLE, North Carolina, USA

    Claude L. Hughes

  2. Michael Waters Consulting, Hillsborough, North Carolina, USA

    Michael D. Waters

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All authors [C.H., M.W., D.A., and I.O.] declare that they have no competing interests. Quintiles, Inc. [C.H.] is a pharmaceutical services company that conducts pharmaceutical and biotechnology research and product development for numerous sponsors but does not own pharmaceutical or biotechnology products. Integrated Laboratory Systems, Inc. [D.A.] is a research and testing services company that does not own pharmaceutical or biotechnology products.

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Hughes, C.L., Waters, M.D., Allen, D., Obasanjo, I. (2016). The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline. In: Hughes, C., Waters, M. (eds) Translational Toxicology. Molecular and Integrative Toxicology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-27449-2_1

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