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Lipoylation of E2 component

  • Chapter
Alpha-Keto Acid Dehydrogenase Complexes

Part of the book series: MCBU Molecular and Cell Biology Updates ((MCBU))

Summary

Lipoic acid is a prosthetic group of the acyltransferase (E2) components of the pyruvate, (α-ketoglutarate, and branched chain α-keto acid dehydrogenase complexes, X component (the dihydrolipoamide dehydrogenase-binding protein) of the eucaryotic pyruvate dehydrogenase complex, and H-protein of the glycine cleavage system. The lipoyl moiety is attached in amide linkage to the ε-amino group of specific lysine residues of the proteins. Although the role of lipoic acid in these proteins has been well studied, intensive research on enzyme(s) concerning the lipoylation of proteins have not been undertaken until recently. In this chapter, we describe the recent development about the lipoylation of E2 component and H-protein as well as the historical view of the studies about lipoylation.

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Author information

Authors and Affiliations

  1. The Institute for Enzyme Research, The University of Tokushima, Tokushima, 770, Japan

    Y. Motokawa, K. Fujiwara & K. Okamura-Ikeda

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  1. Y. Motokawa
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  2. K. Fujiwara
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  3. K. Okamura-Ikeda
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Editor information

Editors and Affiliations

  1. Department of Biochemistry School of Medicine and Biomedical Sciences, State University of New York, 140 Farber Hall 3435 Main Street, 14214, Buffalo, New York, USA

    Mulchand S. Patel

  2. Department of Biochemistry, Kansas State University, 104 Willard Hall, 66506, Manhattan, KS, USA

    Thomas E. Roche

  3. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 635 Barnhill Drive, 46202, Indianapolis, IN, USA

    Robert A. Harris

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Motokawa, Y., Fujiwara, K., Okamura-Ikeda, K. (1996). Lipoylation of E2 component. In: Patel, M.S., Roche, T.E., Harris, R.A. (eds) Alpha-Keto Acid Dehydrogenase Complexes. MCBU Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-8981-0_8

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  • DOI: https://doi.org/10.1007/978-3-0348-8981-0_8

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9853-9

  • Online ISBN: 978-3-0348-8981-0

  • eBook Packages: Springer Book Archive

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