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Modulators of free radical activity in diabetes mellitus: Role of ascorbic acid

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Free Radicals and Aging

Part of the book series: EXS ((EXS,volume 62))

Summary

Free radical mechanisms are increasingly being implicated in the pathogenesis of tissue damage in diabetes. Various sources of free radicals may modulate oxidative stress in diabetes, including non-enzymatic glycosylation of proteins and monosaccharide autooxidation, polyol pathway activity, indirect production of free radicals through cell damage from other causes, and reduced antioxidant reserve. Ascorbic acid, which may be a principal modulator of free radical activity in diabetes, is shown to be consumed, presumably through free radical scavenging, thus preserving levels of other antioxidants such as glutathione.

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Authors and Affiliations

  1. University Department of Geriatric Medicine, University of Wales College of Medicine, CF2 1SZ, Cardiff, UK

    Alan J. Sinclair

  2. Wolfson Laboratories, University of Birmingham, B15 2TT, UK

    Joseph Lunec

  3. Department of Mathematics and Statistics, University of Birmingham, B15 2TT, UK

    Alan J. Girling

  4. Department of Medicine, University of Birmingham, B15 2TT, UK

    Anthony H. Barnett

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  1. Alan J. Sinclair
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  2. Joseph Lunec
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  3. Alan J. Girling
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  4. Anthony H. Barnett
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Editors and Affiliations

  1. C.N.R.S., Institut Biomédical des Cordeliers, Université Pierre et Marie Curie, 15–21, Rue de l’Ecole de Médecine, F-75006, Paris, France

    Ingrid Emerit (Directeur de Recherche) (Directeur de Recherche)

  2. Department of Biochemistry and Biophysics, University of Pennsylvania, D-501 Richards Building, 19104-6089, Philadelphia, PA, USA

    Britton Chance

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© 1992 Birkhäuser Verlag Basel/Switzerland

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Sinclair, A.J., Lunec, J., Girling, A.J., Barnett, A.H. (1992). Modulators of free radical activity in diabetes mellitus: Role of ascorbic acid. In: Emerit, I., Chance, B. (eds) Free Radicals and Aging. EXS, vol 62. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7460-1_34

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  • DOI: https://doi.org/10.1007/978-3-0348-7460-1_34

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7462-5

  • Online ISBN: 978-3-0348-7460-1

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