Summary
A new theory of aging based on the rate of DNA damage is presented, and the relationship between the rate of oxidative DNA damage and maximum life span (MLS) of mammalian species is explored. In humans the level of oxidative DNA damage, as measured by urinary biomarkers, can be modulated by caloric restriction and dietary composition. Consequently, longevity may depend not only on the basal metabolic rate but also on dietary caloric intake and the type of diet. The theory may provide the basis for a practical approach for reduction of degenerative diseases in-general, extension of life expectancy, and optimization of individual lifestyles.
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References
Ames, B. N. (1989) Mutagenesis and carcinogenesis: Endogenous and exogenous factors. Environ. Mol. Mutagen. 14: 16, 66–77.
Basu, A. K., Loechler, E. L., Leadon, S. A., and Essigman, J. M. (1989) Genetic effects of thymine glycol: Site-specific mutagenesis and molecular modeUng studies. Proc. Natl. Acad. Sci. USA 86: 7677–7681.
Bergtold, D. S., Simic, M. G., Alessio, H., and Cutler, R. G. (1988) Urine biomarkers for oxidative DNA damage, in: Oxygen Radicals in Biology and Medicine, pp. 483–490. Eds M. G. Simic, K. A. Taylor, J. F. Ward and C. von Sonntag. Plenum Press, New York.
Bergtold, D. S., and Simic, M. G. (1991) Hydroxy radical in radiation dosimetry and metabolism: Dietary caloric effect, in: Trends in Biological Dosimetry, pp. 21–32. Eds B. Gledhill and F. Mauro. J. Wiley & Sons, New York.
Bergtold, D. S., Cutler, R. G., and Simic, M. G. (1992) to be published.
Cathcart, R., Schwiers, E., Saul, R. L., and Ames, B. N. (1984) Thymine glycol and thymidine glycol in human and rat urine: A possible assay for oxidative DNA damage. Proc. Natl. Acad. Sci. (USA) 81: 5633–5637.
Chance, B., Sies, H., and Boveris, A. (1979) Hydroperoxide metabohsm in manamalian organs. Physiol. Rev. 59: 527–605.
Chevion, M. (1988) A site-specific mechanism for free radical induced biological damage: The essential role of redox-active transition metals. Free Radical Biol. Med. 5: 27–37.
Cutler, R. G. (1985) Antioxidants and longevity of mammalian species, in: Molecular Biology of Aging, pp. 15–73. Eds A. D. Woodhead, A. D. Blackett and A. Hollaender. Plenum Press, New York.
Dizdaroglu, M., and Bergtold, D. S. (1986) Characterization of free radical-induced base damage in DNA at biologically relevant levels. Analyt. Biochem. 156: 182–188.
Dizdaroglu, M. (1991) Chemical determination of free radical-induced damage to DNA. Free Radical Biol. Med. 10: 225–242.
Emerit, I., Packer, L., and Auclair, C. (1990) Antioxidants in therapy and Preventive Medicine. Plenum Press, New York.
Fishbein, L. (Ed.) (1991) Biological Effects of Dietary Restrictions. Springer-Verlag, New York.
Fraga, C. G., Shigenaga, M. K., Park, J. W., Degan, P., and Ames, B. N. (1990) Oxidative damage to DNA during aging. Proc. Natl. Acad. Sci. 87: 4533–4537.
Friedberg, E. C. (1985) DNA Repair. W. H. Freeman & Co., New York.
Harman, D. (1981) The aging process. Proc. Natl. Acad. Sci. USA 78: 7124–7128.
Imlay, J. A., Chin, S. M., and Lynn, S. (1988) Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science 240: 640–642.
Karam, L. R., Bergtold, D. S., and Simic, M. G. (1991) Biomarkers of OH radical damage in vivo. Free Rad. Res. Comms. 12–13: 11–16.
Lindahl, T., Sedgwick, B., Sekiguchi, M., and Nakabeppu, Y. (1988) Regulation and expression of the adaptive response to alkylating agents. Ann. Rev. Biochem. 57: 133–157.
Masoro, E. J., Yu, B. P., and Bertrand, H. A. (1982) Action of food restriction in delaying the aging process. Proc. Natl. Acad. Sci. (USA) 79: 4239–4241.
McCay, C. M., Crowell, M. F., and Maynard, L. A. (1935) The effect of retarded growth upon the length of the life span and upon the ultimate body size. J. Nutr. 10: 3.
McCay, C. M., Sperling, G., and Barnes, L. L. (1943) Growth, aging, chronic diseases and life span in rats. Arch. Biochem. Biophys. 2: 469.
McCord, J. M., and Fridovich, I. (1969) Superoxide dismutase. J. Biol. Chem. 244: 6049–6055.
Moraes, E., Keyse, S., and Tyrell, R. (1990) Mutagenesis by hydrogen peroxide treatment of mammalian cells: A molecular analysis. Carcinogenesis 11: 283–293.
Nohl, H., and Jordan, W. (1986) The mitochondrial site of superoxide formation. Biochem. Biophys. Res. Comm. 138: 533–539.
Peari, R. (1928) The Rate of Living. Alfred Knopf, New York.
Richter, C., Park, J. W., and Ames, B. N. (1988) Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. Natl. Acad. Sci. USA 85: 6465–6467.
Rubner, M. (1908) Das Problem der Lebensdauer und Seine Beziehungen Zun Wachstum und Ernährung, Oldenbourg, Munich.
Sacher, G. A. (1977) Life table modification and life prolongation, in: Handbook of the Biology of Aging, pp. 582–638. Eds C. E. Finch and L. Hayfiick. Van Nostrand Reinhold, New York.
Shibutani, S., Takeshita, M., and Grollman, A. P. (1991) Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349: 431–434.
Shigenaga, M. K., and Ames, B. N. (1991) Assays for 8-hydroxy-2’-deoxyguanosine: A biomarker of in vivo oxidative DNA damage. Free Radical Biol. Med. 10: 211–216.
Simic, M. G., Taylor, K. A., Ward, J. F., and von Sonntag, C. (Eds.) (1988) Oxygen Radicals in Biology and Medicine. Plenum Press, New York.
Simic, M. G., and Bergtold, D. S. (1991a) Dietary modulation of DNA damage in humans. Mutat. Res. 250: 17–24.
Simic, M. G., and Bergtold, D. S. (1991b) Urinary biomarkers of oxidative DNA base damage and human caloric intake, in: Biological Effects of Dietary Restriction, pp. 217–225. Ed. L. Fishbein. Springer-Verlag, New York.
Simic, M. G. (1992) Urinary biomarkers and the rate of DNA damage in carcinogenesis and anticarcinogenesis. Mutat. Res. (in press).
Szatrowski, T. P., and Nathan, C. F. (1991) Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51: 794–798.
Turturro, A., and Hart, R. W. (1991) Caloric restriction and its effects on molecular parameters especially DNA repair, in: Biological Effects of Dietary Restriction, pp. 185–190. Ed. L. Fishbein. Springer-Verlag, New York.
Vijg, J. (1990) DNA sequence changes in aging: How frequent, how important? Aging 2: 105–123.
von Sonntag, C. (1987) The Chemical Basis of Radiation Biology. Taylor and Francis, New York.
Weindruch, R., and Walford, R. L. (1988) The retardation of aging and disease by dietary restriction. Charles C. Thomas Publishers, Springfield, Illinois.
Yu, B. P. (1991) Free radicals and modulation by dietary restriction. Age & Nutrition 2: 84–89.
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© 1992 Birkhäuser Verlag Basel/Switzerland
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Simic, M.G. (1992). The rate of DNA damage and aging. In: Emerit, I., Chance, B. (eds) Free Radicals and Aging. EXS, vol 62. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7460-1_3
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DOI: https://doi.org/10.1007/978-3-0348-7460-1_3
Publisher Name: Birkhäuser Basel
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