Abstract
Dioxopiperazines have three regioisomeric forms (1–3) which are derived from fundamentally different bond-disconnection precursors. The 2,3-dioxopiperazines (1) may be viewed as resulting from reaction of a disubstituted ethylenediamine and an α-dicarbonyl fragment such as oxalate. 2,5-Dioxopiperazines (2) are cyclodipeptides obtained via condensation of two α-amino acids. 2,6-Dioxopiperazines (3) may be viewed as cyclized imide derivatives of the corresponding di(carboxymethyl)amines. Hopefully, this review shall serve investigators not only as a summary of important progress, but as a catalyst for new biomedical research initiatives involving one or more classes of these interesting heterocycles.
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Witiak, D.T., Wei, Y. (1990). Dioxopiperazines: Chemistry and biology. In: Jucker, E. (eds) Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Progress in Drug Research, vol 35. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-7133-4_7
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