Fact-Checking Generative AI: Ontology-Driven Biological Graphs for Disease-Gene Link Verification

  • Conference paper
  • First Online:
Computational Science – ICCS 2024 (ICCS 2024)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 14835))

Included in the following conference series:

  • 107 Accesses

Abstract

Since the launch of various generative AI tools, scientists have been striving to evaluate their capabilities and contents, in the hope of establishing trust in their generative abilities. Regulations and guidelines are emerging to verify generated contents and identify novel uses. we aspire to demonstrate how ChatGPT claims are checked computationally using the rigor of network models. We aim to achieve fact-checking of the knowledge embedded in biological graphs that were contrived from ChatGPT contents at the aggregate level. We adopted a biological networks approach that enables the systematic interrogation of ChatGPT’s linked entities. We designed an ontology-driven fact-checking algorithm that compares biological graphs constructed from approximately 200,000 PubMed abstracts with counterparts constructed from a dataset generated using the ChatGPT-3.5 Turbo model. In 10-samples of 250 randomly selected records a ChatGPT dataset of 1000 “simulated” articles , the fact-checking link accuracy ranged from 70% to 86%. This study demonstrated high accuracy of aggregate disease-gene links relationships found in ChatGPT-generated texts.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 74.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. OpenAI. ChatGPT: Conversational ai assistant. OpenAI Platform (2023). Accessed 14 Aug 2023

    Google Scholar 

  2. Van Dis, E.A., Bollen, J., Zuidema, W., Van Rooij, R., Bockting, C.L.: ChatGPT: five priorities for research. Nature 614(7947), 224–226 (2023)

    Article  Google Scholar 

  3. Przymusinski, T.C.: An algorithm to compute circumscription. Artif. Intell. 38(1), 49–73 (1989)

    Article  MathSciNet  Google Scholar 

  4. Query rewriting for ontology-mediated conditional answers (2020)

    Google Scholar 

  5. Torralba, A., Efros, A.A.: Unbiased look at dataset bias (2011)

    Google Scholar 

  6. Minker, J.: On indefinite databases and the closed world assumption. In: Loveland, D.W. (ed.) CADE 1982. LNCS, vol. 138, pp. 292–308. Springer, Heidelberg (1982). https://doi.org/10.1007/BFb0000066

    Chapter  Google Scholar 

  7. Tchechmedjiev, A., et al.: CLAIMSKG: a knowledge graph of fact-checked claims. Semant. Web - ISWC 11779, 2019 (2019)

    Google Scholar 

  8. Vedula, N., Parthasarathy, S.: Face-keg: fact checking explained using knowledge graphs. In: Proceedings of the 14th ACM International Conference on Web Search and Data Mining, pp. 526–534 (2021)

    Google Scholar 

  9. Lin, P., Song, Q., Shen, J., Wu, Y.: Discovering graph patterns for fact checking in knowledge graphs. In: Pei, J., Manolopoulos, Y., Sadiq, S., Li, J. (eds.) DASFAA 2018. LNCS, vol. 10827, pp. 783–801. Springer, Cham (2018). https://doi.org/10.1007/978-3-319-91452-7_50

    Chapter  Google Scholar 

  10. Lin, P., Song, Q., Yanhong, W.: Fact checking in knowledge graphs with ontological subgraph patterns. Data Sci. Eng. 3, 341–358 (2018)

    Article  Google Scholar 

  11. Lin, P., Song, Q., Yinghui, W., Pi, J.: Discovering patterns for fact checking in knowledge graphs. J. Data Inf. Qual. (JDIQ) 11(3), 1–27 (2019)

    Article  Google Scholar 

  12. Ciampaglia, G.L., Shiralkar, P., Rocha, L.M., Bollen, J., Menczer, F., Flammini, A.: Computational fact checking from knowledge networks. PloS One 10(6), e0128193 (2015)

    Article  Google Scholar 

  13. Wang, S., Wang, L., Mao, W.: A kg-based enhancement framework for fact checking using category information. In: 2020 IEEE International Conference on Intelligence and Security Informatics (ISI), pp. 1–6. IEEE (2020)

    Google Scholar 

  14. Khandelwal, S., Kumar, D.: Computational fact validation from knowledge graph using structured and unstructured information. In: Proceedings of the 7th ACM IKDD CoDS and 25th COMAD, pp. 204–208 (2020)

    Google Scholar 

  15. Orthlieb, T., Abdessalem, H.B., Frasson, C.: Checking method for fake news to avoid the twitter effect. In: Cristea, A.I., Troussas, C. (eds.) ITS 2021. LNCS, vol. 12677, pp. 68–72. Springer, Cham (2021). https://doi.org/10.1007/978-3-030-80421-3_8

    Chapter  Google Scholar 

  16. Shi, B., Weninger, T.: Proje: embedding projection for knowledge graph completion. In: Proceedings of the AAAI Conference on Artificial Intelligence, AAAI 2017, pp. 1236–1242. AAAI Press (2017)

    Google Scholar 

  17. Wang, S., Mao, W., Wei, P., Zeng, D.D.: Knowledge structure driven prototype learning and verification for fact checking. Knowl.-Based Syst. 238, 107910 (2022)

    Article  Google Scholar 

  18. Mengoni, P., Yang, J.: Empowering covid-19 fact-checking with extended knowledge graphs. In: International Conference on Computational Science and its Applications, pp. 138–150. Springer, Heidelberg (2022). https://doi.org/10.1007/978-3-031-10536-4_10

  19. Kim, J., Choi, K.S.: Unsupervised fact checking by counter-weighted positive and negative evidential paths in a knowledge graph. In: Proceedings of the 28th International Conference on Computational Linguistics (2020)

    Google Scholar 

  20. Kim, J.S., Choi, K.S.: Fact checking in knowledge graphs by logical consistency. Semantic Web J. swj2721 (2021)

    Google Scholar 

  21. Zhu, B., Zhang, X., Gu, M., Deng, Y.: Knowledge enhanced fact checking and verification. IEEE/ACM Trans. Audio Speech Lang. Process. 29, 3132–3143 (2021)

    Article  Google Scholar 

  22. Pan, S., Luo, L., Wang, Y., Chen, C., Wang, J., Wu, X.: A roadmap, Unifying large language models and knowledge graphs (2023)

    Google Scholar 

  23. Yang, L., Chen, H., Li, Z., Ding, X., Wu, X.: Chatgpt is not enough: enhancing large language models with knowledge graphs for fact-aware language modeling (2023)

    Google Scholar 

  24. Pubmed central (pmc). Accessed 2 Sept 2023

    Google Scholar 

  25. Hofer, P., Neururer, S., Goebel, G.: Semi-automated annotation of biobank data using standard medical terminologies in a graph database, vol. 228 (2017)

    Google Scholar 

  26. Sow, A., Guissé, A., Niang, O.: Enrichment of medical ontologies from textual clinical reports: towards improving linking human diseases and signs. In: Bassioni, G., Kebe, C.M.F., Gueye, A., Ndiaye, A. (eds.) InterSol 2019. LNICST, vol. 296, pp. 104–115. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-34863-2_10

    Chapter  Google Scholar 

  27. Huntley, R.P., et al.: The GOA database: gene ontology annotation updates for 2015. Nucleic Acids Res. 43(D1), D1057–D1063 (2015)

    Article  Google Scholar 

  28. Gene ontology annotations and resources. Nucleic Acids Res. 41 (2013)

    Google Scholar 

  29. Camon, E., et al.: The gene ontology annotation (goa) project: implementation of go in swiss-prot, trembl, and interpro (2003)

    Google Scholar 

Download references

Acknowledgments

This research is supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement Sano No 857533 and carried out within the International Research Agendas programme of the Foundation for Polish Science, co-financed by the European Union under the European Regional Development Fund, Additionally, is created as part of the Ministry of Science and Higher Education’s initiative to support the activities of Excellence Centers established in Poland under the Horizon 2020 program based on the agreement No MEiN/2023/DIR/3796’

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ahmed Abdeen Hamed .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Hamed, A.A., Crimi, A., Lee, B.S., Misiak, M.M. (2024). Fact-Checking Generative AI: Ontology-Driven Biological Graphs for Disease-Gene Link Verification. In: Franco, L., de Mulatier, C., Paszynski, M., Krzhizhanovskaya, V.V., Dongarra, J.J., Sloot, P.M.A. (eds) Computational Science – ICCS 2024. ICCS 2024. Lecture Notes in Computer Science, vol 14835. Springer, Cham. https://doi.org/10.1007/978-3-031-63772-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-63772-8_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-63771-1

  • Online ISBN: 978-3-031-63772-8

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics

Navigation