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Drug Delivery Systems for Intervertebral Disc

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Drug Delivery Systems for Musculoskeletal Tissues

Abstract

Intervertebral disc (IVD) degeneration is one of the most common degenerative joint diseases that cause pain and disability in adults. It is also a major cause of chronic lower back pain. Early-stage intervention generally focuses on therapies for pain relief while surgical interventions are indicated when non-operative therapies do not achieve a desirable outcome. Since the nature of the disease is localised, nanosystems in drug delivery have a significant potential to improve therapeutic outcomes due to their ability to modify drug retention time or target specific areas due to their smaller size, facilitating penetration and diffusion within the IVD matrix. In addition, different parameters such as material formulation, production techniques, size and surface properties can be augmented to load a wide range of drugs and bioactive. The release profile of therapeutic agents is affected by conditions such as pH, temperature, degradation, drug diffusion and binding interactions. Having prolonged, controlled and targeted releases of bioactive can minimise the number of drug concentrations and injection frequencies at the affected area. This section highlights the drug delivery systems for intervertebral disc application, including nanoparticles, nanofibres, liposomes, dendrimers and micelles, which can optimally carry such bioactivity for enhanced therapeutic results.

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Funding

We received funding from the Health Research Board, Ireland for the Emerging Investigator Award for Health 2022 (grant number EIA-2022-010), Ministry of Higher Education, Malaysia for the Fundamental Research Grant Scheme (grant number FRGS/1/2022/SKK10/UKM/02/12) and Universiti Kebangsaan Malaysia for the Geran Galakan Penyelidik Muda (grant number GGPM-2022-029).

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Authors and Affiliations

  1. CÚRAM, SFI Research Centre for Medical Devices, School of Medicine, University of Galway, Galway, Ireland

    Isma Liza Mohd Isa & Raed H. Ogaili

  2. Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

    Isma Liza Mohd Isa

  3. Centre for Tissue Engineering and Regenerative Medicine (CTERM), Faculty of Medicine, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia

    Syafira Masri, Loai A. Elfawy, Safa Tahri, Ibrahim N. Amirrah, Revatyambigai Subramaniam & Mh. Busra Fauzi

  4. Laboratory of Auto-immunity, Cancer and Immunogenetics, University Hospital Habib Bourguiba, Sfax, Tunisia

    Safa Tahri

  5. Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

    Wan Chiew Ng

  6. Department of Ophthalmology, Faculty Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

    Nur Amalia Ra’oh

  7. Department of Medical Devices, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), Gandhinagar, Gujarat, India

    Akshay Srivastava

  8. Department of Orthopaedics and Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

    Sabarul Afian Mokhtar

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  1. Isma Liza Mohd Isa
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Correspondence to Isma Liza Mohd Isa .

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  1. School of Biosciences & Bioengineering, Indian Institute of Technology Mandi, Mandi, Himachal Pradesh, India

    Sumit Murab

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Mohd Isa, I. et al. (2024). Drug Delivery Systems for Intervertebral Disc. In: Murab, S. (eds) Drug Delivery Systems for Musculoskeletal Tissues. Springer, Cham. https://doi.org/10.1007/978-3-031-55653-1_4

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