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Unlocking the Memory Vault: Dopamine, Novelty, and Memory Consolidation in the Hippocampus

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Synaptic Tagging and Capture

Abstract

Most everyday memories, including numerous episodic memories formed automatically in the hippocampus, are forgotten. However, some memories are retained for extended periods through a memory stabilization process known as cellular or initial memory consolidation. Notably, in both animals and humans, the retention of everyday memories is enhanced during novel experiences occurring shortly before or after memory encoding, a process known as synaptic tagging and capture (STC). A growing body of evidence suggests that dopamine signaling via D1/D5 receptors in the hippocampus is crucial for the persistence of synaptic plasticity and memory, highlighting its significant role in novelty-associated memory enhancement. This chapter presents an overview of key findings related to the persistence of synaptic plasticity and memory in the hippocampus through hippocampal D1/D5 receptor dependency, with special emphasis on the emerging role of the locus coeruleus (LC) in novelty-associated dopamine-dependent memory consolidation. Furthermore, two distinct dopaminergic systems are explored (the ventral tegmental area (VTA)-hippocampal and LC-hippocampal systems), and the specialization mechanisms of each system in different memory consolidation processes are discussed. Additionally, the anatomical and molecular foundations of D1/D5 receptor-mediated signaling in the LC-hippocampal system are examined. Finally, the molecular mechanisms possibly underlying distinct novelty-associated memory enhancement are discussed, including the involvement of plasticity-related proteins (PRPs) in the stabilization of structural and functional changes at potentiated synapses, culminating in initial memory consolidation in the hippocampus.

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Acknowledgments

This study was supported by grants from the Novo Nordisk Foundation Young Investigator Award 2017 (NNF17OC0026774), Lundbeckfonden (DANDRITE-R248-2016-2518), and the PROMEMO Center for Proteins in Memory, a Center of Excellence funded by the Danish National Research Foundation (DNRF133). I would like to thank Kristoffer Højgaard and Taichi Hiraga for their contributions to the scientific discussion. I am grateful for the support from Yasunari Koyama (KOYAMA Medical and Welfare Group), Daisaku Sawada (Sugamo Sougou Chiryoin), Shinji Adachi (DAIWA KIKO CO. LTD.), and the Tokyo Future Lions Club.

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No competing interests exist.

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Authors and Affiliations

  1. Danish Research Institute of Translational Neuroscience – DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, Denmark

    Tomonori Takeuchi

  2. Center for Proteins in Memory – PROMEMO, Danish National Research Foundation, Department of Biomedicine, Aarhus University, Aarhus C, Denmark

    Tomonori Takeuchi

  3. Gftd DeSci, Gftd DAO, Tokyo, Japan

    Tomonori Takeuchi

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Correspondence to Tomonori Takeuchi .

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  1. Physiology and Health Longevity, National University of Singapore, Kent Ridge, Singapore

    Sreedharan Sajikumar

  2. Iowa Neuroscience Institute, University of Iowa, Iowa City, IA, USA

    Ted Abel

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Takeuchi, T. (2024). Unlocking the Memory Vault: Dopamine, Novelty, and Memory Consolidation in the Hippocampus. In: Sajikumar, S., Abel, T. (eds) Synaptic Tagging and Capture. Springer, Cham. https://doi.org/10.1007/978-3-031-54864-2_14

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