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Quantum Dots Nanocomposites as Drug Delivery Vehicle

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Quantum Dots Based Nanocomposites

Part of the book series: Engineering Materials ((ENG.MAT.))

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Abstract

Quantum dots nanocomposites (QDNCs) has triggered enormous interest in, its applications in various fields of medicine and pharmaceutical science due to its unique properties. While QDNCs has demonstrated suitable potential as an imaging probe in medical imaging, its application as a nano-vehicle in drug delivery system for drugs and biomolecules in biomedicine, has only begun to be consideration. Advanced nano-carriers with slow, controllable release and excellent carrier efficiency are now considered the ideal vehicle for develo** drug delivery systems. Remarkable properties of QDNCs include chemical stability, extremely large surface area, and low toxicity making it a promising material to design of novel drug delivery systems. Recent research has demonstrated significant success in the use of QDNCs for medical applications, including its utilization as a vehicle for controlled drug delivery, as well as in photothermal therapy, photodynamic therapy, and theranostic application. This chapter, presents a comprehensive overview of the current studies of drug delivery systems based on QDNCs vehicle. Moreover, various strategies for nano-vehicle design, functionalization methods for effective drug delivery, and reduction of quantum dots toxicity and the essential features for design of new Quantum dots nanocomposites vehicle in photothermal therapy, photodynamic therapy, and controlled drug delivery presented.

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Abbreviations

Ag:

Silver

BBB:

Blood-Brain Barrier

BPQD:

Black Phosphorous quantum dots

BPQDs@Lipo:

Black Phosphorous quantum dots liposome composite

CdSe:

Cadmium Selenide

CSCs:

Cancer Stem Cells

CLSM:

Confocal Laser Scanning Microscope

CMOS:

Complementary Metal-Oxide-Semiconductor

CQD:

Carbon Quantum Dots

DAPI:

4′,6-Diamidino-2-phenylindole

DOX:

Doxorubicin

EPR:

Enhanced Permeability and Retention

FA:

Folic Acid

FAR:

Folate Receptors

FRET:

Förster Resonance Energy Transfer

GQD:

Graphene quantum dots

GOQD:

Graphene oxide quantum dots

HP:

HematoPorphyrin

IC50:

Inhibitory concentration

In:

Indium

InP:

Indium Phosphate

MAP:

Maximum Amplitude Projection

MDDS:

Multi Drug Delivery Systems

MoS2:

Molybdenum Disulfide

MUA:

Mercaptoundecanoic

NIR:

Near-Infrared

PA:

Photoacoustic

PDT:

Photodynamic Therapy

PEG:

Polyethylene glycol

PLGA:

Poly (lactic-co-glycolic acid)

PTT:

Photothermal Therapy

QD:

Quantum Dots

QDNC:

Quantum dots nanocomposites

R&D:

Research and Development

ROS:

Reactive Oxygen Species

S:

Sulfur

SOSG:

Singlet Oxygen Sensor Green

TDD:

Targeted Drug Delivery

WPU:

Waterborne polyurethane

Zn:

Zinc

ZnS:

Zinc Sulfide

ZnSe:

Zinc Selenide

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Authors and Affiliations

  1. School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Seyed Ahmad Dehdast & Omid Pourdakan

Authors
  1. Seyed Ahmad Dehdast
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  2. Omid Pourdakan
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Correspondence to Seyed Ahmad Dehdast .

Editor information

Editors and Affiliations

  1. School of Chemical Sciences, Mahatma Gandhi University, Kottayam, Kerala, India

    Sabu Thomas

  2. School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada

    Poushali Das

  3. Department of Chemistry, University of Waterloo, Waterloo, ON, Canada

    Sayan Ganguly

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Dehdast, S.A., Pourdakan, O. (2024). Quantum Dots Nanocomposites as Drug Delivery Vehicle. In: Thomas, S., Das, P., Ganguly, S. (eds) Quantum Dots Based Nanocomposites. Engineering Materials. Springer, Cham. https://doi.org/10.1007/978-3-031-54779-9_16

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