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Pulmonary Drug Delivery

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Essential Pharmaceutics

Part of the book series: AAPS Introductions in the Pharmaceutical Sciences ((AAPSINSTR,volume 12))

Abstract

This chapter provides an introductory overview on concepts related to drug delivery to the lungs. Physiological barriers to lung delivery are examined, as are the mechanisms for overcoming these barriers through delivery device and formulation design. A review is provided of delivery mechanisms and design of the three major classes of pulmonary drug delivery devices (pressurized metered dose inhalers, nebulizers, and dry powder inhalers). For each class of device, appropriate formulation approaches are discussed.

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Further Reading

Suggested readings for the student include the following texts:

  • Brunaugh A, Smyth HD. Process optimization and particle engineering of micronized drug powders via milling. Drug Deliv Transl Res. 2018;8(6):1740–50.

    Article  CAS  PubMed  Google Scholar 

  • Brunaugh AD, Smyth HD. Formulation techniques for high dose dry powders. Int J Pharm. 2018;547(1–2):489–98.

    Article  CAS  PubMed  Google Scholar 

  • Dalby R, Spallek M, Voshaar T. A review of the development of Respimat® Soft Mist™ Inhaler. Int J Pharm. 2004;283(1–2):1–9.

    Article  CAS  PubMed  Google Scholar 

  • Moon C, Smyth HD, Watts AB, Williams RO. Delivery technologies for orally inhaled products: an update. AAPS PharmSciTech. 2019;20(3):117.

    Article  CAS  PubMed  Google Scholar 

  • Moraga-Espinoza DF, Brunaugh AB, Ferrati S, Heersema LA, Herpin MJ, Martins PP, Zhang H, Smyth HDC. Overview of the delivery technologies for inhalation aerosols. In: Inhalation aerosols: physical and biological basis for therapy. 3rd ed. Boca Raton: CRC Press; 2019.

    Google Scholar 

  • Smyth HD. The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers. Adv Drug Deliv Rev. 2003;55(7):807–28.

    Article  CAS  PubMed  Google Scholar 

  • Smyth HD, Hickey AJ. Carriers in drug powder delivery. Am J Drug Deliv. 2005;3(2):117–32.

    Article  CAS  Google Scholar 

  • Smyth HD, Hickey AJ, editors. Controlled pulmonary drug delivery. Springer Science & Business Media; 2011.

    Google Scholar 

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Author information

Authors and Affiliations

  1. College of Pharmacy, University of Michigan–Ann Arbor, Ann Arbor, MI, USA

    Ashlee D. Brunaugh

  2. University of Valparaíso, Valparaíso, Chile

    Daniel Moraga-Espinoza & Tania Bahamondez-Canas

  3. College of Pharmacy, The University of Texas at Austin, Austin, TX, USA

    Hugh D. C. Smyth & Robert O. Williams

Authors
  1. Ashlee D. Brunaugh
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  2. Daniel Moraga-Espinoza
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  3. Tania Bahamondez-Canas
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  4. Hugh D. C. Smyth
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  5. Robert O. Williams
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© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG

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Brunaugh, A.D., Moraga-Espinoza, D., Bahamondez-Canas, T., Smyth, H.D.C., Williams, R.O. (2024). Pulmonary Drug Delivery. In: Essential Pharmaceutics. AAPS Introductions in the Pharmaceutical Sciences, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-031-52520-9_13

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