Abstract
Antimicrobial nanomaterials have received a lot of interest in recent years due to their potential to fight against microbial illnesses and make the world a safer place. This discussion will focus on free and immobilized antimicrobial nanoparticles and will attempt to address concerns regarding their potential uses, risks, and challenges. In contrast to antimicrobial nanoparticles that are immobilized, or fixed to a substrate or surface, free antimicrobial nanomaterials are those that are suspended in a medium. This chapter will explore the various applications of free and immobilized antimicrobial nanoparticles, including medicine, water purification, food packaging, and consumer goods. The antibacterial effectiveness, durability, and user-friendliness of each form will be compared and reviewed. Concerns about the toxicity of such nanomaterials and other potential negative effects on the environment will also be addressed for practical applications. In addition, this study will reveal the challenges linked to the actual use of free and immobilized antimicrobial nanoparticles. Scalability, efficiency, cost, and compliance with rules and regulations, as well as sustainability, will also be investigated. The key to optimizing the use of antimicrobial nanoparticles and removing limitations to their wider adoption is a thorough understanding of these issues. In summary, this discussion will focus on the differences between free and immobilized antimicrobial nanoparticles, as well as their potential uses, risks, and obstacles. The results will aid scientists, lawmakers, and businesses in making informed choices regarding the application of antimicrobial nanomaterials.
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References
Abazari, M., Badeleh, S. M., Khaleghi, F., Saeedi, M., & Haghi, F. (2023). Fabrication of silver nanoparticles-deposited fabrics as a potential candidate for the development of reusable facemasks and evaluation of their performance. Scientific Reports, 13, 1–16.
Gudkov, S. V., Burmistrov, D. E., Serov, D. A., Rebezov, M. B., Semenova, A. A., & Lisitsyn, A. B. (2021). A mini review of antibacterial properties of ZnO nanoparticles. Frontiers of Physics, 9, 1–12.
Valodkar, M., Modi, S., Pal, A., & Thakore, S. (2011). Synthesis and anti-bacterial activity of Cu, Ag and Cu-Ag alloy nanoparticles: A green approach. Materials Research Bulletin, 46, 384–389.
Singhal, S. K., Lal, M., Kabi, S. R., & Mathur, R. B. (2012). Synthesis of Cu/CNTs nanocomposites for antimicrobial activity. Advances in Natural Sciences: Nanoscience and Nanotechnology, 3, 045011.
Li, C., Wang, X., Chen, F., Zhang, C., Zhi, X., Wang, K., & Cui, D. (2013). The antifungal activity of graphene oxide-silver nanocomposites. Biomaterials, 34, 3882–3890.
Baptista, P. V., McCusker, M. P., Carvalho, A., Ferreira, D. A., Mohan, N. M., Martins, M., & Fernandes, A. R. (2018). Nano-strategies to fight multidrug resistant bacteria-“A battle of the titans”. Frontiers in Microbiology, 9, 1–26.
Firouzjaei, M. D., Shamsabadi, A. A., Sharifian, G. M., Rahimpour, A., & Soroush, M. (2018). A novel nanocomposite with superior antibacterial activity: A silver-based metal organic framework embellished with graphene oxide. Advanced Materials Interfaces, 5, 1701365.
Padmanaban, V. C., Giri Nandagopal, M. S., Madhangi Priyadharshini, G., Maheswari, N., Janani Sree, G., & Selvaraju, N. (2016). Advanced approach for degradation of recalcitrant by nanophotocatalysis using nanocomposites and their future perspectives. International journal of Environmental Science and Technology, 13, 1591–1606.
Shalaby, T., Mahmoud, O., & Al-Oufy, A. (2016). Antibacterial silver embedded nanofibers for water disinfection. International Journal of Materials Science and Applications, 4, 293.
Al-Sherbini, A. S. A., Ghannam, H. E. A., El-Ghanam, G. M. A., El-Ella, A. A., & Youssef, A. M. (2019). Utilization of chitosan/ag bionanocomposites as eco-friendly photocatalytic reactor for bactericidal effect and heavy metals removal. Heliyon, 5, e01980.
Grass, G., Rensing, C., & Solioz, M. (2011). Metallic copper as an antimicrobial surface. Applied and Environmental Microbiology, 77, 1541–1547.
Agnihotri, S., Mukherji, S., & Mukherji, S. (2013). Immobilized silver nanoparticles enhance contact killing and show highest efficacy: Elucidation of the mechanism of bactericidal action of silver. Nanoscale, 5, 7328.
Ramyadevi, J., Jeyasubramanian, K., Marikani, A., Rajakumar, G., & Rahuman, A. A. (2012). Synthesis and antimicrobial activity of copper nanoparticles. Materials Letters, 71, 114–116.
Li, X., Robinson, S. M., Gupta, A., Saha, K., Jiang, Z., Moyano, D. F., Sahar, A., Riley, M. A., & Rotello, V. M. (2014). Functional gold nanoparticles as potent antimicrobial agents against multi-drug-resistant bacteria. ACS Nano, 8, 10682–10686.
Vazquez-Munoz, R., Arellano-Jimenez, M. J., & Lopez-Ribot, J. L. (2020). Bismuth nanoparticles obtained by a facile synthesis method exhibit antimicrobial activity against Staphylococcus aureus and Candida albicans. BMC Biomedical Engineering, 2, 11.
Prabhu, S., & Poulose, E. K. (2012). Silver nanoparticles: Mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. International Nano Letters, 2, 32.
Pelgrift, R. Y., & Friedman, A. J. (2013). Nanotechnology as a therapeutic tool to combat microbial resistance. Advanced Drug Delivery Reviews, 65, 1803–1815.
Jung, W. K., Koo, H. C., Kim, K. W., Shin, S., Kim, S. H., & Park, Y. H. (2008). Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli. Applied and Environmental Microbiology, 74, 2171–2178.
Mukherji, S., Bharti, S., Shukla, G., & Mukherji, S. (2019). Synthesis and characterization of size- and shape-controlled silver nanoparticles. Physical Sciences Reviews, 4, 20170082.
Pal, S., Tak, Y. K., & Song, J. M. (2007). Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? A study of the gram-negative bacterium escherichia coli. Applied and Environmental Microbiology, 73, 1712–1720.
Hong, X., Wen, J., **ong, X., & Hu, Y. (2016). Shape effect on the antibacterial activity of silver nanoparticles synthesized via a microwave-assisted method. Environmental Science and Pollution Research, 23, 4489–4497.
Shaheen, T. I., & Fouda, A. (2018). Green approach for one-pot synthesis of silver nanorod using cellulose nanocrystal and their cytotoxicity and antibacterial assessment. International Journal of Biological Macromolecules, 106, 784–792.
Bharti, S., Mukherji, S., & Mukherji, S. (2021). Enhanced antibacterial activity of decahedral silver nanoparticles. Journal of Nanoparticle Research, 23, 36.
Dakal, T. C., Kumar, A., Majumdar, R. S., & Yadav, V. (2016). Mechanistic basis of antimicrobial actions of silver nanoparticles. Frontiers in Microbiology, 7, 1–17.
Huang, Y. W., Wu, C. H., & Aronstam, R. S. (2010). Toxicity of transition metal oxide nanoparticles: Recent insights from in vitro studies. Materials (Basel), 3, 4842–4859.
Liga, M. V., Bryant, E. L., Colvin, V. L., & Li, Q. (2011). Virus inactivation by silver doped titanium dioxide nanoparticles for drinking water treatment. Water Research, 45, 535–544.
Hasan, A., Morshed, M., Memic, A., Hassan, S., Webster, T. J., & Marei, H. E. S. (2018). Nanoparticles in tissue engineering: Applications, challenges and prospects. International Journal of Nanomedicine, 13, 5637–5655.
Mba, I. E., & Nweze, E. I. (2021). Nanoparticles as therapeutic options for treating multidrug-resistant bacteria: Research progress, challenges, and prospects. World Journal of Microbiology and Biotechnology, 37, 1–30.
Rubilar, O., Rai, M., Tortella, G., Diez, M. C., Seabra, A. B., & Durán, N. (2013). Biogenic nanoparticles: Copper, copper oxides, copper sulphides, complex copper nanostructures and their applications. Biotechnology Letters, 35, 1365–1375.
Younas, H., Qazi, I. A., Hashmi, I., Awan, M. A., Mahmood, A., & Qayyum, H. A. (2014). Visible light photocatalytic water disinfection and its kinetics using Ag-doped titania nanoparticles. Environmental Science and Pollution Research International, 21, 740–752.
Sánchez-López, E., Gomes, D., Esteruelas, G., Bonilla, L., Lopez-Machado, A. L., Galindo, R., Cano, A., Espina, M., Ettcheto, M., Camins, A., et al. (2020). Metal-based nanoparticles as antimicrobial agents: An overview. Nanomaterials, 10, 1–39.
Sirelkhatim, A., Mahmud, S., Seeni, A., Kaus, N. H. M., Ann, L. C., Bakhori, S. K. M., Hasan, H., & Mohamad, D. (2015). Review on zinc oxide nanoparticles: Antibacterial activity and toxicity mechanism. Nano-Micro Letters, 7, 219–242.
Moschini, E., Colombo, G., Chirico, G., Capitani, G., Dalle-Donne, I., & Mantecca, P. (2023). Biological mechanism of cell oxidative stress and death during short-term exposure to nano cuo. Scientific Reports, 13, 1–18.
Nguyen, K. V. T., Ameer, F. S., Anker, J. N., Brumaghim, J. L., & Minh, H. C. (2017). Reactive oxygen species generation by copper(ii) oxide nanoparticles determined by DNA damage assays and EPR spectroscopy. Nanotoxicology, 11, 278–288.
Siddiqi, K. S., & ur Rahman A, Tajuddin, Husen A. (2018). Properties of zinc oxide nanoparticles and their activity against microbes. Nanoscale Research Letters, 13, 141.
Zhang, L., Qi, H., Yan, Z., Gu, Y., Sun, W., & Zewde, A. A. (2017). Sonophotocatalytic inactivation of e. coli using ZnO nanofluids and its mechanism. Ultrasonics Sonochemistry, 34, 232–238.
Mendes, C. R., Dilarri, G., Forsan, C. F., Sapata, V. D. M. R., Lopes, P. R. M., de Moraes, P. B., Montagnolli, R. N., Ferreira, H., & Bidoia, E. D. (2022). Antibacterial action and target mechanisms of zinc oxide nanoparticles against bacterial pathogens. Scientific Reports, 12, 1–10.
Irshad, M. A., Nawaz, R., ur Rehman, M. Z., Adrees, M., Rizwan, M., Ali, S., Ahmad, S., & Tasleem, S. (2021). Synthesis, characterization and advanced sustainable applications of titanium dioxide nanoparticles: A review. Ecotoxicology and Environmental Safety, 212, 111978.
Kearns, H., Goodacre, R., Jamieson, L. E., Graham, D., & Faulds, K. (2017). SERS detection of multiple antimicrobial-resistant pathogens using nanosensors. Analytical Chemistry, 89, 12666–12673.
Gamage McEvoy, J., & Zhang, Z. (2014). Antimicrobial and photocatalytic disinfection mechanisms in silver-modified photocatalysts under dark and light conditions. Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 19, 62–75.
Bharti, S., Mukherji, S., & Mukherji, S. (2018). Photocatalytic action of silver-titanium dioxide nanocomposite against pathogenic bacteria. Journal of the Indian Chemical Society, 95, 1–8.
Skwarczynski, M., Bashiri, S., Yuan, Y., Ziora, Z. M., Nabil, O., Masuda, K., Khongkow, M., Rimsueb, N., Cabral, H., Ruktanonchai, U., et al. (2022). Antimicrobial activity enhancers: Towards smart delivery of antimicrobial agents. Antibiotics, 11, 1–28.
Trevors, J. T. (1987). Silver resistance and accumulation in bacteria. Enzyme and Microbial Technology, 9, 331–333.
Cooksey, D. A. (1993). Copper uptake and resistance in bacteria. Molecular Microbiology, 7, 1–5.
Bondarczuk, K., & Piotrowska-Seget, Z. (2013). Molecular basis of active copper resistance mechanisms in Gram-negative bacteria. Cell Biology and Toxicology, 29, 397–405.
Niño-Martínez, N., Salas Orozco, M. F., Martínez-Castañón, G.-A., Torres Méndez, F., & Ruiz, F. (2019). Molecular mechanisms of bacterial resistance to metal and metal oxide nanoparticles. International Journal of Molecular Sciences, 20, 2808.
Hemmatian, T., Lee, H., & Kim, J. (2021). Bacteria adhesion of textiles influenced by wettability and pore characteristics of fibrous substrates. Polymers (Basel), 13, 1–14.
Leishangthem, D., Yumkhaibam, M. A. K., Henam, P. S., & Nagarajan, S. (2018). An insight into the effect of composition for enhance catalytic performance of biogenic Au/Ag bimetallic nanoparticles. Journal of Physical Organic Chemistry, 31, e3815.
Sharaf, E. M., Hassan, A., FA, A. L.-S., Albalwe, F. M., Albalawi, H. M. R., Darwish, D. B., & Fayad, E. (2022). Synergistic antibacterial activity of compact silver/magnetite core-shell nanoparticles core shell against Gram-negative foodborne pathogens. Frontiers in Microbiology, 13, 1–12.
Álvarez-Paino, M., Muñoz-Bonilla, A., & Fernández-García, M. (2017). Antimicrobial polymers in the nano-world. Nanomaterials, 7, 48.
Spirescu, V. A., Chircov, C., Grumezescu, A. M., & Andronescu, E. (2021). Polymeric nanoparticles for antimicrobial therapies: An up-to-date overview. Polymers (Basel), 13, 724.
Wang, Y., & Sun, H. (2021). Polymeric nanomaterials for efficient delivery of antimicrobial agents. Pharmaceutics, 13, 2108.
Maliszewska, I., & Czapka, T. (2022). Electrospun polymer nanofibers with antimicrobial activity. Polymers (Basel), 14, 1–32.
Yang, J., Wang, K., Yu, D. G., Yang, Y., Bligh, S. W. A., & Williams, G. R. (2020). Electrospun janus nanofibers loaded with a drug and inorganic nanoparticles as an effective antibacterial wound dressing. Materials Science and Engineering: C, 111, 110805.
Duan, X., Chen, H., & Guo, C. (2022). Polymeric nanofibers for drug delivery applications: A recent review. Journal of Materials Science. Materials in Medicine, 33, 78.
Ferreira, M., Ogren, M., Dias, J. N. R., Silva, M., Gil, S., Tavares, L., Aires-da-Silva, F., Gaspar, M. M., & Aguiar, S. I. (2021). Liposomes as antibiotic delivery systems: A promising nanotechnological strategy against antimicrobial resistance. Molecules, 26, 2047.
Mubeen, B., Ansar, A. N., Rasool, R., Ullah, I., Imam, S. S., Alshehri, S., Ghoneim, M. M., Alzarea, S. I., Nadeem, M. S., & Kazmi, I. (2021). Nanotechnology as a novel approach in combating microbes providing an alternative to antibiotics. Antibiotics, 10, 1473.
Bharti, S., Anant, P. S., & Kumar, A. (2023). Nanotechnology in stem cell research and therapy. Journal of Nanoparticle Research, 25, 6.
Pham, S. H., Choi, Y., & Choi, J. (2020). Stimuli-responsive nanomaterials for application in antitumor therapy and drug delivery. Pharmaceutics, 12, 1–19.
Werengowska-Ciećwierz, K., Wiśniewski, M., Terzyk, A. P., & Furmaniak, S. (2015). The chemistry of bioconjugation in nanoparticles-based drug delivery system. Advances in Condensed Matter Physics, 2015, 1–27.
Pandey, S., Shaikh, F., Gupta, A., Tripathi, P., & Yadav, J. S. (2022). A recent update: Solid lipid nanoparticles for effective drug delivery. Advanced Pharmaceutical Bulletin, 12, 17–33.
Mohanta, Y. K., Chakrabartty, I., Mishra, A. K., Chopra, H., Mahanta, S., Avula, S. K., Patowary, K., Ahmed, R., Mishra, B., Mohanta, T. K., et al. (2023). Nanotechnology in combating biofilm: A smart and promising therapeutic strategy. Frontiers in Microbiology, 13, 1–30.
Ganie, A. S., Bano, S., Khan, N., Sultana, S., Rehman, Z., Rahman, M. M., Sabir, S., Coulon, F., & Khan, M. Z. (2021). Nanoremediation technologies for sustainable remediation of contaminated environments: Recent advances and challenges. Chemosphere, 275, 130065.
Zare, H., Ahmadi, S., Ghasemi, A., Ghanbari, M., Rabiee, N., Bagherzadeh, M., Karimi, M., Webster, T. J., Hamblin, M. R., & Mostafavi, E. (2021). Carbon nanotubes: Smart drug/gene delivery carriers. International Journal of Nanomedicine, 16, 1681–1706.
Ma, J., **ong, Z., David Waite, T., Ng, W. J., & Zhao, X. S. (2011). Enhanced inactivation of bacteria with silver-modified mesoporous TiO2 under weak ultraviolet irradiation. Microporous and Mesoporous Materials, 144, 97–104.
Bharti, S., Mukherji, S., & Mukherji, S. (2021). Antiviral application of colloidal and immobilized silver nanoparticles. Nanotechnology, 32, 205102.
Agnihotri, S., Mukherji, S., & Mukherji, S. (2014). Size-controlled silver nanoparticles synthesized over the range 5–100 nm using the same protocol and their antibacterial efficacy. RSC Advances, 4, 3974–3983.
Kan, C. X., Zhu, J. J., & Zhu, X. G. (2008). Silver nanostructures with well-controlled shapes: Synthesis, characterization and growth mechanisms. Journal of Physics D: Applied Physics, 41, 155304.
Vassallo, A., Silletti, M. F., Faraone, I., & Milella, L. (2020). Nanoparticulate antibiotic systems as antibacterial agents and antibiotic delivery platforms to fight infections. Journal of Nanomaterials, 2020, 1–31.
Bharti, S., Mukherji, S., & Mukherji, S. (2020). Extracellular synthesis of silver nanoparticles by Thiosphaera pantotropha and evaluation of their antibacterial and cytotoxic effects. 3 Biotech, 10, 1–12.
Giannousi, K., Lafazanis, K., Arvanitidis, J., Pantazaki, A., & Dendrinou-Samara, C. (2014). Hydrothermal synthesis of copper based nanoparticles: Antimicrobial screening and interaction with dna. Journal of Inorganic Biochemistry, 133, 24–32.
Zhu, Y. P., Wang, X. K., Guo, W. L., Wang, J. G., & Wang, C. (2010). Sonochemical synthesis of silver nanorods by reduction of sliver nitrate in aqueous solution. Ultrasonics Sonochemistry, 17, 675–679.
Anandan, S., Grieser, F., & Ashokkumar, M. (2008). Sonochemical synthesis of Au−Ag core−shell bimetallic nanoparticles. Journal of Physical Chemistry C, 112, 15102–15105.
Wuppaladhodi, V., Yang, S., Pouri, H., & Zhang, J. (2023). Laser-assisted process for the deposition of nanostructured anti-microbial coatings on hydrogels. Optics and Laser Technology, 164, 109485.
Agostino, A. D., Taglietti, A., Desando, R., Bini, M., Patrini, M., Dacarro, G., Cucca, L., Pallavicini, P., & Grisoli, P. (2017). Bulk surfaces coated with triangular silver nanoplates: Antibacterial action based on silver release and photo-thermal effect. Nanomaterials, 7, 1–10.
Park, M. H., Duan, X., Ofir, Y., Creran, B., Patra, D., Ling, X. Y., Huskens, J., & Rotello, V. M. (2010). Chemically directed immobilization of nanoparticles onto gold substrates for orthogonal assembly using dithiocarbamate bond formation. ACS Applied Materials & Interfaces, 2, 795–799.
Khayati, G. R., & Janghorban, K. (2012). The nanostructure evolution of Ag powder synthesized by high energy ball milling. Advanced Powder Technology, 23, 393–397.
Esfandyari-Manesh, M., Ghaedi, Z., Asemi, M., Khanavi, M., Manayi, A., Jamalifar, H., Atyabi, F., & Dinarvand, R. (2013). Study of antimicrobial activity of anethole and carvone loaded plga nanoparticles. Journal of Pharmacy Research, 7, 290–295.
Wei, C., Fan, C., **e, D., Zhou, S., Zhang, H., Du, Q., & **, P. (2023). Fabrication of cinnamaldehyde-entrapped ethosome nanoparticles as antimicrobial agent. LWT, 181, 114760.
Imam, H. T., Marr, P. C., & Marr, A. C. (2021). Enzyme entrapment, biocatalyst immobilization without covalent attachment. Green Chemistry, 23, 4980–5005.
Li, W., Li, Y., Sun, P., Zhang, N., Zhao, Y., Qin, S., & Zhao, Y. (2020). Antimicrobial peptide-modified silver nanoparticles for enhancing the antibacterial efficacy. RSC Advances, 10, 38746–38754.
Smoukov, S. K., Bishop, K. J. M., Kowalczyk, B., Kalsin, A. M., & Grzybowski, B. A. (2007). Electrostatically “patchy” coatings via cooperative adsorption of charged nanoparticles. Journal of the American Chemical Society, 129, 15623–15630.
Qi, X., Poernomo, G., Wang, K., Chen, Y., Chan-Park, M. B., Xu, R., & Chang, M. W. (2011). Covalent immobilization of nisin on multi-walled carbon nanotubes: Superior antimicrobial and anti-biofilm properties. Nanoscale, 3, 1874.
Stillger, L., & Müller, D. (2022). Peptide-coating combating antimicrobial contaminations: A review of covalent immobilization strategies for industrial applications. Journal of Materials Science, 57, 10863–10885.
Park, S. Y., Chung, J. W., Priestley, R. D., & Kwak, S.-Y. (2012). Covalent assembly of metal nanoparticles on cellulose fabric and its antimicrobial activity. Cellulose, 19, 2141–2151.
Sathyanarayanan, M. B., Balachandranath, R., Genji Srinivasulu, Y., Kannaiyan, S. K., & Subbiahdoss, G. (2013). The effect of gold and iron-oxide nanoparticles on biofilm-forming pathogens. ISRN Microbiology, 2013, 1–5.
Agnihotri, S., & Dhiman, N. K. (2017). Development of nano-antimicrobial biomaterials for biomedical applications. In A. Tripathi & J. S. Melo (Eds.), Advances in biomaterials for biomedical applications (Advanced structured materials) (Vol. 66, pp. 479–545). Springer Singapore. ISBN 978-981-10-3327-8.
Greenhalgh, R., Dempsey-Hibbert, N. C., & Whitehead, K. A. (2019). Antimicrobial strategies to reduce polymer biomaterial infections and their economic implications and considerations. International Biodeterioration & Biodegradation, 136, 1–14.
Sahoo, J., Sarkhel, S., Mukherjee, N., & Jaiswal, A. (2022). Nanomaterial-based antimicrobial coating for biomedical implants: New age solution for biofilm-associated infections. ACS Omega, 7, 45962–45980.
Zhang, L., Yin, W., Shen, S., Feng, Y., Xu, W., Sun, Y., & Yang, Z. (2022). ZnO nanoparticles interfere with top-down effect of the protozoan paramecium on removing microcystis. Environmental Pollution, 310, 119900.
Alhazmi, N. M. (2022). Fungicidal activity of silver and silica nanoparticles against Aspergillus sydowii isolated from the soil in western Saudi Arabia. Microorganisms, 11, 86.
Bharti, S., Mukherji, S., & Mukherji, S. (2019). Water disinfection using fixed bed reactors packed with silver nanoparticle immobilized glass capillary tubes. Science of The Total Environment, 689, 991–1000.
Sawant, S. N., Selvaraj, V., Prabhawathi, V., & Doble, M. (2013). Antibiofilm properties of silver and gold incorporated PU, PCLM, PC and PMMA nanocomposites under two shear conditions. PLoS One, 8, 1–9.
Hulme, J. (2022). Application of nanomaterials in the prevention, detection, and treatment of methicillin-resistant Staphylococcus aureus (MRSA). Pharmaceutics, 14, 805.
Leong, S., Razmjou, A., Wang, K., Hapgood, K., Zhang, X., & Wang, H. (2014). TiO2 based photocatalytic membranes: A review. Journal of Membrane Science, 472, 167–184.
Dash, K. K., Deka, P., Bangar, S. P., Chaudhary, V., Trif, M., & Rusu, A. (2022). Applications of inorganic nanoparticles in food packaging: A comprehensive review. Polymers (Basel), 14, 521.
Biswas, R., Alam, M., Sarkar, A., Haque, M. I., Hasan, M. M., & Hoque, M. (2022). Application of nanotechnology in food: Processing, preservation, packaging and safety assessment. Heliyon, 8, e11795.
Kaur, J., Sood, K., Bhardwaj, N., Arya, S. K., & Khatri, M. (2020). Nanomaterial loaded chitosan nanocomposite films for antimicrobial food packaging. Materials Today Proceedings, 28, 1904–1909.
Nile, S. H., Baskar, V., Selvaraj, D., Nile, A., **ao, J., & Kai, G. (2020). Nanotechnologies in food science: Applications, recent trends, and future perspectives. Nano-Micro Letters, 12, 45.
Hardy, A., Benford, D., Halldorsson, T., Jeger, M. J., Knutsen, H. K., More, S., Naegeli, H., Noteborn, H., Ockleford, C., Ricci, A., et al. (2018). Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health. EFSA Journal, 16, 5327.
More, S., Bampidis, V., Benford, D., Bragard, C., Halldorsson, T., Hernández-Jerez, A., Bennekou, S. H., Koutsoumanis, K., Lambré, C., Machera, K., et al. (2021). Guidance on technical requirements for regulated food and feed product applications to establish the presence of small particles including nanoparticles. EFSA Journal, 19, 6769.
Salleh, A., Naomi, R., Utami, N. D., Mohammad, A. W., Mahmoudi, E., Mustafa, N., & Fauzi, M. B. (2020). The potential of silver nanoparticles for antiviral and antibacterial applications: A mechanism of action. Nanomaterials, 10, 1566.
Montes-Hernandez, G., Di Girolamo, M., Sarret, G., Bureau, S., Fernandez-Martinez, A., Lelong, C., & Eymard, V. E. (2021). In situ formation of silver nanoparticles (Ag-NPs) onto textile fibers. ACS Omega, 6, 1316–1327.
Ribeiro, A. I., Shvalya, V., Cvelbar, U., Silva, R., Marques-Oliveira, R., Remião, F., Felgueiras, H. P., Padrão, J., & Zille, A. (2022). Stabilization of silver nanoparticles on polyester fabric using organo-matrices for controlled antimicrobial performance. Polymers (Basel), 14, 1138.
Abraham, J., Dowling, K., & Florentine, S. (2021). Can copper products and surfaces reduce the spread of infectious microorganisms and hospital-acquired infections? Materials (Basel), 14, 1–27.
Imani, S. M., Ladouceur, L., Marshall, T., Maclachlan, R., Soleymani, L., & Didar, T. F. (2020). Antimicrobial nanomaterials and coatings: Current mechanisms and future perspectives to control the spread of viruses including sars-cov-2. ACS Nano, 14, 12341–12369.
Kaci, M., Belhaffef, A., Meziane, S., Dostert, G., Menu, P., Velot, D. S., & Arab-Tehrany, E. (2018). Nanoemulsions and topical creams for the safe and effective delivery of lipophilic antioxidant coenzyme Q10. Colloids Surfaces B Biointerfaces, 167, 165–175.
Gupta, V., Mohapatra, S., Mishra, H., Farooq, U., Kumar, K., & Iqbal, Z. (2022). Nanotechnology in cosmetics and cosmeceuticals — A review. Gels, 8, 1–31.
Hosseini, M., Chin, A. W. H., Williams, M. D., Behzadinasab, S., Falkinham, J. O., Poon, L. L. M., & Ducker, W. A. (2022). Transparent anti-SARS-CoV-2 and antibacterial silver oxide coatings. ACS Applied Materials & Interfaces, 14, 8718–8727.
Liu, M., Huang, L., Xu, X., Wei, X., Yang, X., Li, X., Wang, B., Xu, Y., Li, L., & Yang, Z. (2022). Copper doped carbon dots for addressing bacterial biofilm formation, wound infection, and tooth staining. ACS Nano, 16, 9479–9497.
Nguyen, T. M. T., Wang, P. W., Hsu, H. M., Cheng, F. Y., Bin, S. D., Wong, T. Y., & Chang, H. J. (2019). Dental cement’s biological and mechanical properties improved by ZnO nanospheres. Materials Science and Engineering: C, 97, 116–123.
Esteban Florez, F. L., Hiers, R. D., Larson, P., Johnson, M., O’Rear, E., Rondinone, A. J., & Khajotia, S. S. (2018). Antibacterial dental adhesive resins containing nitrogen-doped titanium dioxide nanoparticles. Materials Science and Engineering: C, 93, 931–943.
Deng, Y., Yang, L., Huang, X., Chen, J., Shi, X., Yang, W., Hong, M., Wang, Y., Dargusch, M. S., & Chen, Z. G. (2018). Dual Ag/ZnO-decorated micro−/nanoporous sulfonated polyetheretherketone with superior antibacterial capability and biocompatibility via layer-by-layer self-assembly strategy. Macromolecular Bioscience, 18, 1–12.
Wang, S., Wu, J., Yang, H., Liu, X., Huang, Q., & Lu, Z. (2017). Antibacterial activity and mechanism of Ag/ZnO nanocomposite against anaerobic oral pathogen streptococcus mutans. Journal of Materials Science. Materials in Medicine, 28, 1–8.
Li, X., Qi, M., Sun, X., Weir, M. D., Tay, F. R., Oates, T. W., Dong, B., Zhou, Y., Wang, L., & Xu, H. H. K. (2019). Surface treatments on titanium implants via nanostructured ceria for antibacterial and anti-inflammatory capabilities. Acta Biomaterialia, 94, 627–643.
Liu, Z., Du, M., Liu, H., Zhang, K., Xu, X., Liu, K., Tu, J., & Liu, Q. (2021). Chitosan films incorporating litchi peel extract and titanium dioxide nanoparticles and their application as coatings on watercored apples. Progress in Organic Coatings, 151, 106103.
Fadiji, T., Rashvand, M., Daramola, M. O., & Iwarere, S. A. (2023). A review on antimicrobial packaging for extending the shelf life of food. PRO, 11, 1–30.
Dong, X., Liang, X., Zhou, Y., Bao, K., Sameen, D. E., Ahmed, S., Dai, J., Qin, W., & Liu, Y. (2021). Preparation of polylactic acid/ TiO2/GO nano-fibrous films and their preservation effect on green peppers. International Journal of Biological Macromolecules, 177, 135–148.
Pirsa, S., & Shamusi, T. (2019). Intelligent and active packaging of chicken thigh meat by conducting nano structure cellulose-polypyrrole-zno film. Materials Science and Engineering: C, 102, 798–809.
Darwesh, O. M., Li, H., & Matter, I. A. (2023). Nano-bioremediation of textile industry wastewater using immobilized cuo-nps myco-synthesized by a novel cu-resistant Fusarium oxysporum osf18. Environmental Science and Pollution Research, 30, 16694–16706.
Alias, S. S., Harun, Z., Azhar, F. H., Ibrahim, S. A., & Johar, B. (2020). Comparison between commercial and synthesised nano flower-like rutile TiO2 immobilised on green super adsorbent towards dye wastewater treatment. Journal of Cleaner Production, 251, 119448.
Sboui, M., Lachheb, H., Bouattour, S., Gruttadauria, M., La Parola, V., Liotta, L. F., & Boufi, S. (2021). TiO2/Ag2O immobilized on cellulose paper: A new floating system for enhanced photocatalytic and antibacterial activities. Environmental Research, 198, 111257.
Jabbar, Z. H., Okab, A. A., Graimed, B. H., Issa, M. A., & Ammar, S. H. (2023). Fabrication of Ag-C3N4 nanosheets immobilized Bi2S3/Ag2WO4 nanorods for photocatalytic disinfection of Staphylococcus aureus cells in wastewater: Dual s-scheme charge separation pathway. Journal of Photochemistry and Photobiology A: Chemistry, 438, 114556.
Hidayat, D., Lestari, W. W., Dendy, D., Khoerunnisa, F., Handayani, M., Sanjaya, E. H., & Gunawan, T. (2023). Adsorption studies of anionic and cationic dyes on mil-100(cr) synthesized using facile and green mechanochemical method. Journal of Inorganic and Organometallic Polymers and Materials, 33, 1548–1561.
Nafady, A., Albaqami, M. D., & Alotaibi, A. M. (2023). Recycled polypropylene waste as abundant source for antimicrobial, superhydrophobic and electroconductive nonwoven fabrics comprising polyaniline/silver nanoparticles. Journal of Inorganic and Organometallic Polymers and Materials, 33, 1306–1316.
Nguyen, N.-T., Vu, T.-H., Bui, V.-H., Phan, D.-N., Nguyen, T.-H., & Nguyen, T.-M.-L. (2023). Investigation of the antimicrobial and physico-mechanical properties of nature-friendly nanosilver-loaded pig lining leather prepared using exhaustion method. PRO, 1891, 11.
Masa, A., Jehsoh, N., Dueramae, S., & Hayeemasae, N. (2023). Boosting the antibacterial performance of natural rubber latex foam by introducing silver-doped zinc oxide. Polymers (Basel), 15, 1040.
Refaee, A. A., El-Naggar, M. E., Mostafa, T. B., Elshaarawy, R. F. M., & Nasr, A. M. (2022). Nano-bio finishing of cotton fabric with quaternized chitosan schiff base-TiO2-ZnO nanocomposites for antimicrobial and uv protection applications. European Polymer Journal, 166, 111040.
Aravind, H. P., Jadhav, S. A., More, V. B., Sonawane, K. D., & Patil, P. S. (2019). Novel one step sonosynthesis and deposition technique to prepare silver nanoparticles coated cotton textile with antibacterial properties. Colloid Journal, 81, 720–727.
Kuehr, S., Kosfeld, V., & Schlechtriem, C. (2021). Bioaccumulation assessment of nanomaterials using freshwater invertebrate species. Environmental Sciences Europe, 33, 9.
Abbas, Q., Yousaf, B., Amina, A. M. U., Munir, M. A. M., El-Naggar, A., Rinklebe, J., & Naushad, M. (2020). Transformation pathways and fate of engineered nanoparticles (ENPs) in distinct interactive environmental compartments: A review. Environment International, 138, 105646.
Devasena, T., Iffath, B., Renjith Kumar, R., Muninathan, N., Baskaran, K., Srinivasan, T., & John, S. T. (2022). Insights on the dynamics and toxicity of nanoparticles in environmental matrices. Bioinorganic Chemistry and Applications, 2022, 1–21.
Singh, K., Thakur, S. S., Ahmed, N., Alharby, H. F., Al-Ghamdi, A. J., Al-Solami, H. M., Bahattab, O., & Yadav, S. (2022). Ecotoxicity assessment for environmental risk and consideration for assessing the impact of silver nanoparticles on soil earthworms. Heliyon, 8, e11167.
Pérez-de-Luque, A. (2017). Interaction of nanomaterials with plants: What do we need for real applications in agriculture? Frontiers in Environmental Science, 5, 1–7.
Gupta, R., & **e, H. (2018). Nanoparticles in daily life: Applications, toxicity and regulations. Journal of Environmental Pathology, Toxicology and Oncology, 37, 139–148.
Wu, J., Bosker, T., Vijver, M. G., & Peijnenburg, W. J. G. M. (2021). Trophic transfer and toxicity of (mixtures of) ag and tio2 nanoparticles in the lettuce–terrestrial snail food chain. Environmental Science & Technology, 55, 16563–16572.
Boros, B.-V., & Ostafe, V. (2020). Evaluation of ecotoxicology assessment methods of nanomaterials and their effects. Nanomaterials, 10, 610.
Pareek, V., Gupta, R., & Panwar, J. (2018). Do physico-chemical properties of silver nanoparticles decide their interaction with biological media and bactericidal action? A review. Materials Science and Engineering: C, 90, 739–749.
Mishra, S., & Sundaram, B. (2023). Fate, transport, and toxicity of nanoparticles: An emerging pollutant on biotic factors. Process Safety and Environment Protection, 174, 595–607.
Angel, B. M., Batley, G. E., Jarolimek, C. V., & Rogers, N. J. (2013). The impact of size on the fate and toxicity of nanoparticulate silver in aquatic systems. Chemosphere, 93, 359–365.
Ferdous, Z., & Nemmar, A. (2020). Health impact of silver nanoparticles: A review of the biodistribution and toxicity following various routes of exposure. International Journal of Molecular Sciences, 21, 2375.
Shi, H., Magaye, R., Castranova, V., & Zhao, J. (2013). Titanium dioxide nanoparticles: A review of current toxicological data. Particle and Fibre Toxicology, 10, 15.
Henkler, F., Tralau, T., Tentschert, J., Kneuer, C., Haase, A., Platzek, T., Luch, A., & Götz, M. E. (2012). Risk assessment of nanomaterials in cosmetics: A european union perspective. Archives of Toxicology, 86, 1641–1646.
**e, S., Manuguri, S., Proietti, G., Romson, J., Fu, Y., Inge, A. K., Wu, B., Zhang, Y., Häll, D., Ramström, O., et al. (2017). Design and synthesis of theranostic antibiotic nanodrugs that display enhanced antibacterial activity and luminescence. Proceedings of the National Academy of Sciences of the United States of America, 114, 8464–8469.
Ye, X., Feng, T., Li, L., Wang, T., Li, P., & Huang, W. (2021). Theranostic platforms for specific discrimination and selective killing of bacteria. Acta Biomaterialia, 125, 29–40.
El-Zowalaty, M. E., Al-Ali, S. H. H., Husseiny, M. I., Geilich, B. M., Webster, T. J., & Hussein, M. Z. (2015). The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities. International Journal of Nanomedicine, 10, 3269–3274.
Song, J., Liu, H., Lei, M., Tan, H., Chen, Z., Antoshin, A., Payne, G. F., Qu, X., & Liu, C. (2020). Redox-channeling polydopamine-ferrocene (PDA-FC) coating to confer context-dependent and photothermal antimicrobial activities. ACS Applied Materials & Interfaces, 12, 8915–8928.
Zohra, T., Numan, M., Ikram, A., Salman, M., Khan, T., Din, M., Salman, M., Farooq, A., Amir, A., & Ali, M. (2021). Cracking the challenge of antimicrobial drug resistance with crispr/cas9, nanotechnology and other strategies in eskape pathogens. Microorganisms, 9, 954.
Sadani, K., Muthuraj, L., Nag, P., Fernandes, M., Kondabagil, K., Mukhopadhyay, C., & Mukherji, S. (2020). A point of use sensor assay for detecting purely viral versus viral-bacterial samples. Sensors and Actuators B: Chemical, 322, 128562.
Nag, P., Sadani, K., Mukherji, S., & Mukherji, S. (2020). Beta-lactam antibiotics induced bacteriolysis on LSPR sensors for assessment of antimicrobial resistance and quantification of antibiotics. Sensors and Actuators B: Chemical, 311, 127945.
Sadani, K., Nag, P., Thian, X. Y., & Mukherji, S. (2022). Enzymatic optical biosensors for healthcare applications. Biosensors and Bioelectronics: X, 12, 100278.
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Bharti, S., Nag, P., Sadani, K., Mukherji, S., Mukherji, S. (2023). Exploring the Application, Safety, and Challenges of Free Versus Immobilized Antimicrobial Nanomaterials. In: Chaughule, R.S., Lokur, A.S. (eds) Applications of Nanotechnology in Microbiology. Springer, Cham. https://doi.org/10.1007/978-3-031-49933-3_5
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