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Estimation of Cardiac Output in Insect Hearts Paced at Different Rates

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IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering (CLAIB 2022, CBEB 2022)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 98))

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Abstract

Insects have been often used as experimental animal models because of their considerable genetic homology with humans, short lifespan and low-cost maintenance. This study aims to estimate hemodynamic parameters (both systolic and the cardiac output) in response to increase in heart rate in the perfused in situ cardiac tube of the mealworm beetle Tenebrio molitor using a software developed in our laboratory, in which the heart is modeled as a prolate spheroid. A negative relationship between rate and the systolic parameters (e.g., stroke volume and ejection fraction) was observed, but the cardiac output was not statistically affected by heart rate. Considering that the end-diastolic volume was not significantly changed by rate, the negative staircase cannot be attributed mostly to the heterometric (Frank-Starling) regulation of cardiac systolic force.

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Acknowledgment

The technical support of Ms. Elizângela S. Oliveira is greatly appreciated. Financial support: Brazilian National Council for Scientific and Technological Development - CNPq (304010/2016-2 grant to JWMB and scholarship, for FHKI, 127197/2021-4); Brazilian Ministry of Health/FINEP (grant# 01-13-0214-00); and Coordination for the Improvement of Higher Education Personnel (CAPES, scholarships for NCBC and ARS).

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Authors and Affiliations

  1. Department of Electronics and Biomedical Engineering, School of Electrical and Computer Engineering, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil

    F. H. K. Inazumi, N. C. B. Calderon, A. R. Santana, R. A. Bassani & J. W. M. Bassani

  2. LabNECC, Center for Biomedical Engineering, UNICAMP, Campinas, SP, Brazil

    F. H. K. Inazumi, N. C. B. Calderon, A. R. Santana, R. A. Bassani & J. W. M. Bassani

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  1. F. H. K. Inazumi
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  2. N. C. B. Calderon
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  3. A. R. Santana
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  4. R. A. Bassani
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  5. J. W. M. Bassani
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Corresponding author

Correspondence to N. C. B. Calderon .

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Editors and Affiliations

  1. Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Federal University of Santa Catarina, Florianópolis, Brazil

    Jefferson Luiz Brum Marques

  2. Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Federal University of Santa Catarina, Florianópolis, Brazil

    Cesar Ramos Rodrigues

  3. Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Federal University of Santa Catarina, Florianópolis, Brazil

    Daniela Ota Hisayasu Suzuki

  4. Institute of Biomedical Engineering, Federal University of Santa Catarina, Florianópolis, Brazil

    José Marino Neto

  5. Institute of Biomedical Engineering, Department of Electrical and Electronic Engineering, Federal University of Santa Catarina, Florianópolis, Brazil

    Renato García Ojeda

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Inazumi, F.H.K., Calderon, N.C.B., Santana, A.R., Bassani, R.A., Bassani, J.W.M. (2024). Estimation of Cardiac Output in Insect Hearts Paced at Different Rates. In: Marques, J.L.B., Rodrigues, C.R., Suzuki, D.O.H., Marino Neto, J., García Ojeda, R. (eds) IX Latin American Congress on Biomedical Engineering and XXVIII Brazilian Congress on Biomedical Engineering. CLAIB CBEB 2022 2022. IFMBE Proceedings, vol 98. Springer, Cham. https://doi.org/10.1007/978-3-031-49401-7_56

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  • DOI: https://doi.org/10.1007/978-3-031-49401-7_56

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-031-49401-7

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