Abstract
Measurements of the melting point of high-purity organic substances are crucial in various fields, such as medicine, biology, and perfumery and cosmetic production. This research was aimed at develo** melting point certified reference materials (CRMs) for organic substances, with metrological traceability to the SI base units for “temperature” (°C). The study analyzes the metrological assurance in the field of melting point measurements, including a reference complex used to measure the melting point and purity of organic substances in the range of + 40 to + 250 °C. The research also identifies the basic requirements for substances eligible as CRMs. The study presents the results of determining the melting point of benzophenone, benzoic acid, succinic acid, anthracene, and caffeine, along with interlaboratory comparisons. To harmonize the results, a method is suggested, which involves presenting the certified value of the melting point determined by direct measurements and certified values of the optical transparency temperature at various heating rates in the certificates of the developed CRMs. These results have theoretical significance in improving the accuracy of measurements in the field of thermal analysis to a higher quality level. The study also outlines research directions for future work.
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Notes
- 1.
Federal Information Fund for Ensuring the Uniformity of Measurements. Available via FIF EUM. https://fgis.gost.ru/fundmetrology. Accessed 7 October 2022.
- 2.
GSO 7895-2001 Caffeine melting point reference material. Available via FIF EUM. https://fgis.gost.ru/fundmetrology/registry/19/items/392091. Accessed 7 October 2022.
GSO 11070-2018 Reference material for the melting point of benzophenone. Available via FIF EUM. https://fgis.gost.ru/fundmetrology/registry/19/items/593689. Accessed 7 October 2022.
GSO 11071-2018 Standard sample of the melting point of benzoic acid. Available via FIF EUM. https://fgis.gost.ru/fundmetrology/registry/19/items/394949. Accessed 7 October 2022.
- 3.
GET 34-2020 State primary standard of temperature unit in the range from 0 to 3200 °C: D. I. Mendeleyev Institute for Metrology. Available via FIF EUM. https://fgis.gost.ru/fundmetrology/registry/12/items/1385580. Accessed 7 October 2022.
Abbreviations
- ILC:
-
Interlaboratory comparison
- MI:
-
Measuring instrument
- CRM:
-
Certified reference material
- FIF EUM:
-
Federal Information Fund for Ensuring the Uniformity of Measurements in Russia
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Acknowledgements
The research was carried out within the research work “Development and study of melting point measurements based on high-purity organic substances” and development work “Creation of a reference complex for measuring the melting point and purity of organic substances” at the D. I. Mendeleyev Institute for Metrology. All measurements were carried out using the equipment of the D. I. Mendeleyev Institute for Metrology.
Contribution of the Authors
Kazartsev Ya. V.—development of measurement methodology, programming, conducting research, carrying out a formal analysis of the data obtained, writing a draft of the article, preparation and creation of visual materials; Korchagina E. N.—development of the idea (concept) of the study, management of research and development work, obtaining funding, revision of the article; Solovev I. V.—conducting research, carrying out a formal analysis of the data obtained, revision of the article.
Conflict of Interest
The article was prepared on the basis of a report presented at the V International Scientific Conference “Reference Materials in Measurement and Technology” (Yekaterinburg, September 13–16, 2022). The article was admitted for publication after the abstract was revised, the article was formalized, and the review procedure was carried out.
The version in the Russian language is published in the journal “Measurement Standards. Reference Materials” 2023;19(1):29–40. (In Russ.). https://doi.org/10.20915/2077-1177-2023-19-1-29-40.
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Kazartsev, Y.V., Korchagina, E.N., Solovev, I.V. (2024). Melting Point Certified Reference Materials for Organic Substances: Development Prospects. In: Sobina, E.P., et al. Reference Materials in Measurement and Technology . RMMT 2022. Springer, Cham. https://doi.org/10.1007/978-3-031-49200-6_18
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