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Carbon Monoxide Against Ischemia-Reperfusion Injury: A Tour into the Immune System

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Gasotransmitters in Organ Transplantation

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Abstract

Carbon monoxide (CO) is quickly moving past its historic label as a molecule once feared, to a therapeutic drug that modulates inflammation. The development of carbon monoxide-releasing molecules (CO-RM) and utilization of heme oxygenase-1 inducers have shown CO to be a promising therapy in reducing renal ischemia-reperfusion injury (IRI) and other inflammatory diseases. In this chapter, we will discuss the developments and application of CO-RM in renal IRI, and organ transplantation as well as the anti-inflammatory mechanisms of CO in respect to mitigating apoptosis, suppressing dendritic cell maturation and signalling, inhibiting toll-like receptor activation, promoting anti-inflammatory responses, and the effects on renal vasculature.

This chapter is an expanded version by the same authors in the publication titled Carbon monoxide mechanism of protection against renal ischemia and reperfusion injury. Biochem Pharmacol. 2022; 202:115156.

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Authors and Affiliations

  1. Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Aaron M. Kwong, Patrick P. W. Luke & Rabindra N. Bhattacharjee

  2. Division of Urology, Department of Surgery, London Health Sciences Center, Western University, London, ON, Canada

    Patrick P. W. Luke & Rabindra N. Bhattacharjee

  3. Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON, Canada

    Patrick P. W. Luke & Rabindra N. Bhattacharjee

  4. Multi-Organ Transplant Program, London Health Sciences Center, Western University, London, ON, Canada

    Patrick P. W. Luke

  5. Department of Surgery, Division of Urology, London Health Sciences Center, University of Western Ontario, London, ON, Canada

    George J. Dugbartey

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Kwong, A.M., Luke, P.P.W., Dugbartey, G.J., Bhattacharjee, R.N. (2024). Carbon Monoxide Against Ischemia-Reperfusion Injury: A Tour into the Immune System. In: Gasotransmitters in Organ Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-031-48067-6_6

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