Herbs and Herbal Formulations for the Management and Prevention of Gastrointestinal Diseases

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Herbal Medicine Phytochemistry

Abstract

Diseases affecting the digestive tract’s activities are referred to as GIT disorders. Stomach or abdominal pain, dyspepsia, bloating, diarrhea, constipation, dysentery, vomiting, and gastroenteritis are typical gastrointestinal illnesses. Patients with gastrointestinal issues are routinely treated with herbal or alternative treatments. In several regions of the world, herbs have historically been trusted for the management of numerous illnesses. They are considered vital bases of pharmaceutical items, especially herbal remedies, and their use considerably impacts the delivery of basic health care. Because they have minimal side effects when used appropriately, herbal medications are becoming more and more popular with Westerners. In recent years, a widespread trend has been there toward a resurgence of interest in a conventional system of medical care. According to the WHO, traditional medicine has a place in the primary healthcare system. Medicinal plants remain to be a significant source of treatment in develo** nations. The majority of people in develo** nations, or about 88% of them, are thought to rely on a traditional system of medicine for their medical care. When treating GI problems, evidence-based, rational phytotherapy which employs herbs and herbal preparations to provide the desired therapeutic effect plays a significant role. Given the variety of these disorders, it stands to reason that a wide range of herbal products can be utilized in both prevention and treatment. This chapter aims to review the use of various herbs and herbal preparations for managing and preventing gastrointestinal diseases as well as their safety and efficacy.

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Abbreviations

5-HT:

5-hydroxytryptamine

BMI:

Body mass indices

DFHE:

Dill Fruit Hydroalcoholic Extract

DGL:

Deglycyrrhizinated licorice

DNA:

Deoxyribonucleic acid

ESCOP:

European Scientific Cooperative on Phytotherapy

FD:

Functional Dyspepsia

FGIDs:

Functional gastrointestinal disorders

GERD:

Gastroesophageal Reflux Disease

GI:

Gastrointestinal

GLP-1:

Glucagon-like peptide 1

H2:

Histamine Type 2

IBS:

Irritable Bowel Syndrome

IL 10:

Interleukin 10

LES:

Lower esophageal sphincter

L-NAME:

L-NG-Nitro arginine methyl ester

MMP:

Matrix metalloproteinase

NERD:

Nonerosive reflux disease

PDS:

Postprandial distress syndrome

PKS:

Polyketide synthases

PMO:

Peppermint Oil

POAL:

Probiotics originating from Aloe leaf)

PPIs:

Proton pump inhibitors

QOL:

Quality of Life

RCT:

Randomized control trial

TCM:

Traditional Chinese medicine

TID:

Thrice a day

VEGF:

Vascular endothelial growth factor

WHO:

World Health Organization

XO:

Xanthine oxidase

References

  1. Ley RE, Turnbaugh PJ, Klein S, Gordon JI (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444:1022–1023

    Article  CAS  PubMed  Google Scholar 

  2. Cheng LK, O’Grady GDP, Egbuji JU, Windsor JA, Pullan AJ (2010) Gastrointestinal system. Wiley interdisciplinary reviews. Syst Biol Med 2:65–79

    Google Scholar 

  3. Neamsuvan O, Tuwaemaengae T, Bensulong F, Asae A, Mosamae K (2012) A survey of folk remedies for gastrointestinal tract diseases from Thailand’s three southern border provinces. J Ethnopharmacol 144:11–21

    Article  PubMed  Google Scholar 

  4. Mathabe MC, Nikolova RV, Lall N, Nyazema NZ (2006) Antibacterial activities of medicinal plants used for the treatment of diarrhoea in Limpopo Province, South Africa. J Ethnopharmacol 105:286–293

    Article  CAS  PubMed  Google Scholar 

  5. Karki A, Tiwari BR (2007) Prevalence of acute diarrhoea in Kathmandu valley. JNMA J Nepal Med Assoc 46:175–179

    CAS  PubMed  Google Scholar 

  6. Jeremy S (2022) Brief note on functional and structural gastrointestinal disorder. J Hepatol Gastroint Dis 8

    Google Scholar 

  7. 13 Most Common Gastrointestinal Conditions and What to Do About Them (2020) Available via DIALOG https://www.centurymedicaldental.com/13-most-common-gastrointestinal-conditions-and-what-to-do-about-them/

  8. Salisbury BH, Terrell JM (2022) Antacids. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island

    Google Scholar 

  9. Nugent CC, Falkson SR, Terrell JM (2022) H2 blockers. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island

    Google Scholar 

  10. Yibirin M, De Oliveira D, Valera R, Plitt AE, Lutgen S (2021) Adverse effects associated with proton pump inhibitor use. Cureus 13:e12759

    PubMed  PubMed Central  Google Scholar 

  11. Biswas M, Singh KNM, Shetty YC, Koli PG, Ingawale S, Bhatia SJ (2019) Prescription pattern & adverse drug reactions of prokinetics. Indian J Med Res 149:748–754

    Article  PubMed  PubMed Central  Google Scholar 

  12. World Health Organization (WHO) (1993) Summary of WHO guidelines for the assessment of herbal medicines. Herbal Gram 28:13–14

    Google Scholar 

  13. Cheema HS, Prakash O, Pal A, Khan F, Bawankule DU, Darokar MP (2014) Glabridin induces oxidative stress-mediated apoptosis-like cell death of malaria parasite Plasmodium falciparum. Parasitol Int 63:349–358

    Article  CAS  PubMed  Google Scholar 

  14. Kashyap S, Rao PB, Mishra P, Supriya (2019) Antioxidant potential and activity of aerial parts of eight medicinal plants of Uttarakhand, India. Bangladesh J Bot 48:265–270

    Article  Google Scholar 

  15. Gaur R, Cheema HS, Yadav DK, Singh SP, Darokar MP, Khan F, Bhakuni RS (2015) In vitro antimalarial activity and molecular modeling studies of novel artemisinin derivatives. RSC Adv 5:47959–47974

    Article  CAS  Google Scholar 

  16. Boniface PK, Verma S, Shukla A, Cheema HS, Srivastava SK, Khan F, Darokar MP, Pal A (2015) Bioactivity guided isolation of antiplasmodial constituents from Conyza sumatrensis (Retz.) E.H. Walker. Parasitol Int 64:118–123

    Article  CAS  PubMed  Google Scholar 

  17. Reynolds T, Dweck AC (1999) Aloe vera leaf gel: a review update. J Ethnopharmacol 68:3–37

    Article  CAS  PubMed  Google Scholar 

  18. Eshun K, He Q (2004) Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries – a review. Crit Rev Food Sci Nutr 44:91–96

    Article  PubMed  Google Scholar 

  19. Boudreau MD, Beland FA (2006) An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 24:103–154

    Article  CAS  PubMed  Google Scholar 

  20. Tan Z, Li F, **ng J (2011) Separation and purification of Aloe anthraquinones using PEG/salt aqueous two-phase system. Sep Sci Technol 46:1503–1510

    Article  CAS  Google Scholar 

  21. Mizuuchi Y, Shi SP, Wanibuchi K et al (2009) Novel type III polyketide synthases from Aloe arborescent. FEBS J 276:2391–2401

    Article  CAS  PubMed  Google Scholar 

  22. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S (2006) Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 33:232–237

    Article  CAS  PubMed  Google Scholar 

  23. Babaee N, Zabihi E, Mohseni S, Moghadamnia AA (2012) Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis. Dent Res J (Isfahan) 9:381–385

    PubMed  Google Scholar 

  24. Chapman DD, Pittelli JJ (1974) Double-blind comparison of alophen with its components for cathartic effects. Curr Ther Res Clin Exp 16:817–820

    CAS  PubMed  Google Scholar 

  25. de Witte P (1993) Metabolism and pharmacokinetics of anthranoids. Pharmacology 47:86–97

    Article  PubMed  Google Scholar 

  26. Ulbricht C, Armstrong J, Basch E et al (2007) An evidence-based systematic review of Aloe vera by the natural standard research collaboration. J Herb Pharmacother 7:279–323

    Article  PubMed  Google Scholar 

  27. Kang MC, Kim SY, Kim YT et al (2014) In vitro and in vivo antioxidant activities of polysaccharide purified from Aloe vera (Aloe barbadensis) gel. Carbohydr Polym 99:365–371

    Article  CAS  PubMed  Google Scholar 

  28. Suboj P, Babykutty S, Valiyaparambil Gopi DR, Nair RS, Srinivas P, Gopala S (2012) Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-kappaB. Eur J Pharm Sci 45:581–591

    Article  CAS  PubMed  Google Scholar 

  29. Khare CP (2004) Indian herbal remedies: rational western therapy, ayurvedic and other traditional usages, botany. Springer, Berlin

    Book  Google Scholar 

  30. Pulliah T (2002) Medicinal plants in India. Regency Publications, New Delhi

    Google Scholar 

  31. Hornok L (1992) Cultivation and processing of medicinal plants. Wiley, New York

    Google Scholar 

  32. Sharma R (2004) Agrotechniques of medicinal plants. Daya Publishing House, New Delhi

    Google Scholar 

  33. Santos AG, Figueiredo AC, Lourenco PM, Barrosa JG, Pedro LG (2002) Hairy root cultures of Anethum graveolens (dill): establishment, growth, time-course study of their essential oil and its comparison with parent plant oils. Biotechnol Lett 24:1031–1036

    Article  CAS  Google Scholar 

  34. Blank I, Grosch W (1991) Evaluation of potent odorants in dill seed and dill herb (Anethum graveolens L.) by aroma extract dilution analysis. J Food Sci 56:63–67

    Article  CAS  Google Scholar 

  35. Bonnlander B, Winterhalter P (2000) 9-Hydroxypiperitone beta-D-glucopyranoside and other polar constituents from dill (Anethum graveolens L.) herb. J Agric Food Chem 48:4821–4825

    Article  CAS  PubMed  Google Scholar 

  36. Duke JA (2001) Handbook of medicinal herbs. CRC Press, London

    Google Scholar 

  37. Fleming T (2000) PDR for herbal medicines. Medical Economics Company, Montvale

    Google Scholar 

  38. Nair R, Chanda S (2007) Antibacterial activities of some medicinal plants of the western region of India. Turk J Biol 31:231–236

    Google Scholar 

  39. Hosseinzadeh H, Karimi GR, Ameri M (2002) Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice. BMC Pharmacol 2:21–25

    Article  PubMed  PubMed Central  Google Scholar 

  40. Mahran GH, Kadry HA, Thabet CK, Al-Azizi M, Liv N (1992) GC/MS analysis of volatile oil of fruits of Anethum graveolens. Int J Pharmacog 30:139–144

    Article  CAS  Google Scholar 

  41. Mohele B, Heller W, Wellmann E (1985) UV-induced biosynthesis of quercetin 3-o-beta-d-glucuronide in dill Anethum graveolens cell cultures. Phytochem 24:183–185

    Google Scholar 

  42. Naseri-Gharib MK, Heidari A (2007) Antispasmodic effect of A. graveolens fruit extract on rat ileum. Int J Pharm 3:260–264

    Article  Google Scholar 

  43. Gocmanac-Marija I, Dusanka K, Milica R et al (2015) Spasmolytic effect of Anethum graveolens l. Methanol extract on isolated rat ileum. Acta Med Median 54:5–10

    Article  Google Scholar 

  44. Salehi Surmaghi MH, Amin GR, Kaveh S (2002) Carvi fructus. In: Iranian herbal pharmacopeia scientific committee, 1st edn. Iranian Ministry of Health & Medical Education Publications, Tehran

    Google Scholar 

  45. Johri RK (2011) Cuminum cyminum and Carum carvi: an update. Pharmacogn Rev 5:63–72

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Zheng GQ, Kenney PM, Lam LK (1992) Anethofuran, carvone, and limonene: potential cancer chemopreventive agents from dill weed oil and caraway oil. Planta Med 58:338–341

    Article  CAS  PubMed  Google Scholar 

  47. ESCOP (2003) Monographs: the scientific foundation for herbal medicinal products. Thieme, Stuttgart

    Google Scholar 

  48. Sachan AK, Das DR, Kumar M (2016) Carum carvi-an important medicinal plant. J Chem Pharm Res 8:529–533

    CAS  Google Scholar 

  49. Olennikov DN, Kashchenko NI (2014) Polysaccharides. Current state of knowledge: an experimental and scientometric investigation. Khimiya rastitel’nogo syr’ya 1:5–26

    Google Scholar 

  50. Ravid U, Putievsky E, Katzir I, Weinstein V, Ikan R (1992) Chiral GC analysis of (S)(+)- and (R)(−)-carvone with high enantiomeric purity in caraway, dill and spearmint oils. Flavour Fragr J 7:289–292

    Article  CAS  Google Scholar 

  51. de Carvalho CCCR, da Fonseca MMR (2006) Carvone: why and how should one bother to produce this terpene. Food Chem 95:413–422

    Article  Google Scholar 

  52. Forster HB, Niklas H, Lutz S (1980) Antispasmodic effects of some medicinal plants. Planta Med 40:309–319

    Article  CAS  PubMed  Google Scholar 

  53. Al-Essa MK, Shafagoj YA, Mohammed F, Afifi FU (2010) Relaxant effect of ethanol extract of Carum carvi on dispersed intestinal smooth muscle cells of the Guinea pig. Pharm Biol 48:76–80

    Article  CAS  PubMed  Google Scholar 

  54. Hawrelak JA, Cattley T, Myers SP (2009) Essential oils in the treatment of intestinal dysbiosis: a preliminary in vitro study. Altern Med Rev 14:380–384

    PubMed  Google Scholar 

  55. Khayyal MT, el-Ghazaly MA, Kenawy SA et al (2001) Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination. Arzneimittelforschung 51:545–553

    CAS  PubMed  Google Scholar 

  56. Chey WD, Lacy BE, Cash BD, Epstein M, Shah SM (2017) Randomized controlled trial to assess the efficacy & safety of caraway oil/L-menthol plus usual care polypharmacy vs. placebo plus usual care polypharmacy for functional dyspepsia. Gastroenterology 152:S306

    Article  Google Scholar 

  57. Lauche R, Janzen A, Lüdtke R, Cramer H, Dobos G, Langhorst J (2015) Efficacy of caraway oil poultices in treating irritable bowel syndrome – a randomized controlled cross-over trial. Digestion 92:22–31

    Article  PubMed  Google Scholar 

  58. Bhandari PR, Kamdod MA (2012) Emblica officinalis (Amla): a review of potential therapeutic applications. Int J Green Pharm 6:257–269

    Article  Google Scholar 

  59. Khan KH (2009) Roles of Emblica officinalis in medicine – a review. Bot Res Int 2:218–228

    CAS  Google Scholar 

  60. Khattak KF (2013) Proximate composition, phytochemical profile and free radical scavenging activity of radiation processed Emblica officinalis. Int Food Res J 20:1125–1131

    CAS  Google Scholar 

  61. Jain SK, Khurdiya DS (2004) Vitamin C enrichment of fruit juice based ready-to-serve beverages through blending of Indian gooseberry (Emblica officinalis Gaertn.) juice. Plant Foods Hum Nutr 59:63–66

    Article  CAS  PubMed  Google Scholar 

  62. Zhang LZ, Zhao WH, Guo YJ, Tu GZ, Lin S, **n LG (2003) Studies on chemical constituents in fruits of Tibetan medicine Phyllanthus emblica. Zhongguo Zhong Yao Za Zhi 28:940–943

    CAS  PubMed  Google Scholar 

  63. Rehman H, Yasin KA, Choudhary MA et al (2007) Studies on the chemical constituents of Phyllanthus emblica. Nat Prod Res 21:775–781

    Article  Google Scholar 

  64. Singh E, Sharma S, Pareek A, Dwivedi J, Yadav S, Sharma S (2011) Phytochemistry, traditional uses and cancer chemopreventive activity of Amla (Phyllanthus emblica): the sustainer. J Appl Pharm Sci 2:176–183

    Google Scholar 

  65. Mehrotra S, Jamwal R, Shyam R et al (2011) Anti-helicobacter pylori and antioxidant properties of Emblica officinalis pulp extract: a potential source for therapeutic use against gastric ulcer. J Med Plants Res 5:2577–2583

    Google Scholar 

  66. Al-Rehaily AJ, Al-Howiriny TS, Al-Sohaibani MO, Rafatullah S (2002) Gastroprotective effects of “Amla” Emblica officinalis on in vivo test models in rats. Phytomedicine 9:515–522

    Article  CAS  PubMed  Google Scholar 

  67. Sidhu S, Pandhi P, Malhotra S, Vaiphei K, Khanduja KL (2011) Beneficial effects of Emblica officinalis in L-arginine-induced acute pancreatitis in rats. J Med Food 14:147–155

    Article  CAS  PubMed  Google Scholar 

  68. Deshmukh CD, Bantal V, Pawar A (2010) Protective effect of Emblica officinalis fruit extract on acetic acid-induced colitis in rats. J Herb Med Toxicol 4:25–29

    Google Scholar 

  69. Karkon Varnosfaderani S, Hashem-Dabaghian F, Amin G et al (2018) Efficacy and safety of amla (Phyllanthus emblica L.) in non-erosive reflux disease: a double-blind, randomized, placebo-controlled clinical trial. J Integr Med 16:126–131

    Article  PubMed  Google Scholar 

  70. Muckensturm B, Foechterlen D, Reduron JP, Danton P, Hildenbrand M (1997) Phytochemical and chemotaxonomic studies of Foeniculum vulgare. Biochem Syst Ecol 25:353–358

    Article  CAS  Google Scholar 

  71. Barros L, Carvalho AM, Ferreira ICFR (2010) The nutritional composition of fennel (Foeniculum vulgare): shoots, leaves, stems and inflorescences. LWT- Food Sci Technol 43:814–818

    Article  CAS  Google Scholar 

  72. Agarwal R, Gupta SK, Agarwal SS, Srivastava S, Saxena R (2008) Oculohypotensive effects of Foeniculum vulgare in experimental models of glaucoma. Indian J Physiol Pharmacol 52:77–83

    PubMed  Google Scholar 

  73. Faudale M, Viladomat F, Bastida J, Poli F, Codina C (2008) Antioxidant activity and phenolic composition of wild, edible, and medicinal fennel from different Mediterranean countries. J Agric Food Chem 56:1912–1920

    Article  CAS  PubMed  Google Scholar 

  74. Kunzemann J, Herrmann K (1977) Isolation and identification of flavon(ol)-O-glycosides in caraway (Carum carvi L.), fennel (Foeniculum vulgare Mill.), anise (Pimpinella anisum L.), and coriander (Coriandrum sativum L.), and of flavon-C-glycosides in anise – I. Phenolics of spices. Z Lebensm Unters Forsch 164:194–200

    Article  CAS  PubMed  Google Scholar 

  75. Parejo I, Jauregui O, Sánchez-Rabaneda F, Viladomat F, Bastida J, Codina C (2004) Separation and characterization of phenolic compounds in fennel (Foeniculum vulgare) using liquid chromatography-negative electrospray ionization tandem mass spectrometry. J Agric Food Chem 52:3679–3687

    Article  CAS  PubMed  Google Scholar 

  76. Nassar MI, Aboutabl EA, Makled YA, ElKhrisy EA, Osman AF (2010) Secondary metabolites and pharmacology of Foeniculum vulgare Mill. Subsp. Piperitum. Rev Latinoam de Química 38:103–112

    CAS  Google Scholar 

  77. Cherng J, Chiang W, Chiang L (2008) Immunomodulatory activities of common vegetables and spices of Umbelliferae and its related coumarins and flavonoids. Food Chem 106:944–950

    Article  CAS  Google Scholar 

  78. Roby MHH, Sarhan MA, Selim KA, Khalel KI (2013) Antioxidant and antimicrobial activities of essential oil and extracts of fennel (Foeniculum vulgare L.) and chamomile (Matricaria chamomilla L.). Ind Crops Prod 44:437–445

    Article  CAS  Google Scholar 

  79. Chakǔrski I, Matev M, Koǐchev A, Angelova I, Stefanov G (1981) Treatment of chronic colitis with an herbal combination of Taraxacum officinale, Hipericum perforatum, Melissa officinalis, Calendula officinalis, and Foeniculum vulgare. Intern Dis 20:51–54

    Google Scholar 

  80. Birdane FM, Cemek M, Birdane YO, Gülçin I, Büyükokuroğlu E (2007) Beneficial effects of vulgare ethanol-induced acute gastric mucosal injury in rat. World J Gastroenterol 13:607–611

    Article  PubMed  PubMed Central  Google Scholar 

  81. Fiore C, Eisenhut M, Ragazzi E, Zanchin G, Armanini D (2005) A history of the therapeutic use of liquorice in Europe. J Ethnopharmacol 99:317–324

    Article  PubMed  PubMed Central  Google Scholar 

  82. Hattori M, Sakamoto T, Kobashi K et al (1983) Metabolism of glycyrrhizin by human intestinal flora. Planta Med 48:38–42

    Article  CAS  PubMed  Google Scholar 

  83. Yamamoto K, Kakegawa H, Ueda H et al (1992) Gastric cytoprotective anti-ulcerogenic actions of hydroxyl chalcones in rats. Planta Med 58:389–393

    Article  CAS  PubMed  Google Scholar 

  84. Chandler RF (1985) Licorice, more than just a flavour. Can Pharm J 118:421–424

    Google Scholar 

  85. Doll R, Hill I, Hutton C et al (1962) Clinical trial of a triterpenoid liquorice compound in gastric and duodenal ulcer. Lancet 2:793–796

    Article  Google Scholar 

  86. Wilson JA (1972) A comparison of carbenoxolone sodium and deglycyrrhizinated liquorice in the treatment of gastric ulcer in the ambulant patient. Br J Clin Pract 26:563–566

    Article  CAS  PubMed  Google Scholar 

  87. Morgan AG, Pacsoo C, McAdam WA (1985) Maintenance therapy. A two-year comparison between Caved-S and cimetidine treatment in the prevention of symptomatic gastric ulcer. Gut 26:599–602

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Morgan AG, McAdam WA, Pacsoo C et al (1982) Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy. Gut 23:545–551

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Turpie AG, Runcie J, Thomson TJ (1969) Clinical trial of deglycyrrhizinised liquorice in gastric ulcer. Gut 10:299–303

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Rees WD, Rhodes J, Wright JE et al (1979) Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroent 14:605–607

    Article  CAS  PubMed  Google Scholar 

  91. Kassir ZA (1985) Endoscopic controlled trial of four drug regimens in the treatment of chronic duodenal ulceration. Ir Med J 78:153–156

    CAS  PubMed  Google Scholar 

  92. Tewari SN, Wilson AK (1973) Deglycyrrhizinated liquorice in duodenal ulcer. Practitioner 210:820–823

    CAS  PubMed  Google Scholar 

  93. Rita P, Animesh DK (2011) An Updated overview of Peppermint (Mentha Piperita L.). Int Res J Pharm 2:1–10

    Google Scholar 

  94. Grigoleit HG, Grigoleit P (2005) Peppermint oil in irritable bowel syndrome. Phytomedicine 12:601–606

    Article  CAS  PubMed  Google Scholar 

  95. Loolaie M, Moasef N, Rasouli H, Adibi H (2017) Peppermint and its functionality: a review. Arch Clin Microbiol 4:54

    Google Scholar 

  96. Shah PP, D’Mello PM (2004) A review of medicinal uses and pharmacological effects of Mentha piperita. Nat Prod Rad 3:214–221

    Google Scholar 

  97. Dalvi SS, Nadkarni PM, Pardesi R, Gupta KC (1991) Effect of peppermint oil on gastric emptying in man: a preliminary study using a radiolabelled solid test meal. Indian J Physiol Pharmacol 35:212–214

    CAS  PubMed  Google Scholar 

  98. Tate S (1997) Peppermint oil: a treatment for postoperative nausea. J Adv Nurs 26:543–549

    Article  CAS  PubMed  Google Scholar 

  99. Hill JM, Aronson OI (1991) The mechanism of action of peppermint oil on gastrointestinal smooth muscle an analysis using patch clamp electrophysiology and isolated tissue pharmacology in rabbit and Guinea pig. Gastroenterology 101:55–65

    Article  Google Scholar 

  100. Somerville KW, Ellis WR, Whitten BH, Balfour TW, Bell GD (1985) Stones in the common bile duct: experience with medical dissolution therapy. Postgrad Med J 61:313–316

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Verma A, Mogra R (2015) Psyllium (Plantago ovata) husk: a wonder food for good health. IJSR 4:1581–1585

    Google Scholar 

  102. Theuissen EAM (2008) Water soluble dietary fibers and cardiovascular disease. Physiol Behav 94:285–292

    Article  Google Scholar 

  103. Purohit P, Rathore HS (2019) Isabgol: a herbal remedy. World J Pharm Res 8:579–585

    CAS  Google Scholar 

  104. Shabbir S (2019) Psyllium the hidden superfood of all times. J Nutraceuticals Food Sci 4:1–2

    Google Scholar 

  105. Garg P (2017) Psyllium husk should be taken at higher dose with sufficient water to maximize its efficacy. J Acad Nutr Diet 117(5):681

    Article  PubMed  Google Scholar 

  106. Chaplin MF, Chaudhury S, Dettmer PW, Sykes J, Shaw AD, Davies GJ (2000) Effect of ispaghula husk on the faecal output of bile acids in healthy volunteers. J Steroidal Biochem Mol Biol 72:283–292

    Article  CAS  Google Scholar 

  107. Leeds AR (2009) Dietary fiber; role in nutrition management of disease. In: Caballero B (ed) Guide to nutritional supplements. Academic Press, USA

    Google Scholar 

  108. Ayurvedic Pharmacopoeia of India (1999–2011) Government of India, Ministry of Health and Family Welfare Department of Ayush

    Google Scholar 

  109. Ishikawah T, Sega Y, Kitajima J (2001) Water-soluble constituents of ajowan. Chem Pharm Bull 49:840–844

    Article  Google Scholar 

  110. Chopra RN (1982) Chopra’s indigenous drug of India, 2nd edn. Academic Publishers, Calcutta

    Google Scholar 

  111. Garg SN, Kumar S (1998) A new glucoside from Trachyspermum ammi. Fitoterapia 69:511–512

    CAS  Google Scholar 

  112. Nagalakshmi S, Shankaracharya NB, Naik JP, Rao LJM (2000) Studies on chemical and technological aspects of ajowan (Trachyspermum ammi syn. Carum copticum). J Food Sci Technol 37:277–281

    CAS  Google Scholar 

  113. Choudhury S (1998) Composition of the seed oil of Trachyspermum ammi (L.) Sprague from Northeast India. J Essen Oil Res 10:588–590

    Article  CAS  Google Scholar 

  114. Vasudevan K, Vembar S, Veeraraghavan K, Haranath PS (2000) Influence of intragastric perfusion of aqueous spice extracts on acid secretion in anesthetized albino rats. Indian J Gastroenterol 19:53–56

    CAS  PubMed  Google Scholar 

  115. Ramaswamy S, Sengottuvelu S, Sherief S et al (2010) Gastroprotective activity of Ethanolic extract of Trachyspermum Ammi fruit. Int J Pharm Biosci 1:1–15

    Google Scholar 

  116. Patel K, Srinivasan K (2001) Studies on the influence of dietary spices on food transit time in experimental rats. Nutr Res 21:1309–1314

    Article  Google Scholar 

  117. Gilani AH, Jabeen Q, Ghayur MN, Janbaz KH, Akhtar MS (2005) Studies on the antihypertensive, antispasmodic, bronchodilator and hepatoprotective activities of the Carum copticum seed extract. J Ethnopharmacol 98:127–135

    Article  CAS  PubMed  Google Scholar 

  118. Basch E, Ulbricht C, Kuo G, Szapary P, Smith M (2003) Therapeutic applications of fenugreek. Altern Med Rev 8:20–27

    PubMed  Google Scholar 

  119. Parthasarathy VA, Kandinnan K, Srinivasan S (2008) Fenugreek in: organic spices. New India Publishing Agencies, New Delhi

    Book  Google Scholar 

  120. Grieve M (1984) A modern herbal: the medicinal, culinary, cosmetic and economic properties, cultivation and folklore of herbs, grasses, fungi, shrubs and trees with all their modern scientific uses. Savvas Publishing

    Google Scholar 

  121. U.S. Department of Health and Human Services (2012) National Institutes of Health Website

    Google Scholar 

  122. Verma N, Usman K, Patel N et al (2016) A multicenter clinical study to determine the efficacy of a novel fenugreek seed (Trigonella foenum-graecum) extract (FenfuroTM) in patients with type 2 diabetes. Food Nutr Res 60:32382

    Article  PubMed  Google Scholar 

  123. Helmy H (2011) Study the effect of fenugreek seeds on gastric ulcers in experimental rats. World J Dairy Food Sci 6:152–158

    Google Scholar 

  124. Bhat BG, Sambaiah K, Chandrasekhara N (1985) The effect of feeding fenugreek and ginger on bile composition in the albino rat. Nutr Rep Int 32:1145–1151

    Google Scholar 

  125. DiSilvestro RA, Verbruggen MA, Offutt EJ (2011) Anti-heartburn effects of a fenugreek fiber product. Phytother Res 25:88–91

    Article  CAS  PubMed  Google Scholar 

  126. Haghshenas B, Nami Y, Haghshenas M et al (2015) Effect of addition of inulin and fenugreek on the survival of microencapsulated Enterococcus durans 39C in alginate-psyllium polymeric blends in simulated digestive system and yogurt. Asian J Pharm Sci 10:350–361

    Article  Google Scholar 

  127. Pandian RS, Anuradha CV, Viswanathan P (2002) Gastroprotective effect of fenugreek seeds (Trigonella foenum-graecum) on experimental gastric ulcer in rats. J Ethnopharmacol 81:393–397

    Article  PubMed  Google Scholar 

  128. Anuradha CV, Ravikumar P (1998) Anti-lipid peroxidative activity of seeds of fenugreek (Trigonella foenum-graecum). Med Sci Res 26:317–321

    Google Scholar 

  129. Ligumsky M, Sestieri M, Okon E, Ginsburg I (1995) Antioxidants inhibit ethanol-induced gastric injury in the rat. Role of manganese, glycine, and carotene. Scand J Gastroenterol 30:854–860

    Article  CAS  PubMed  Google Scholar 

  130. Saurez J, Herrera MD, Marhuenda E (1996) Hesperidine and neohesperidin dihydrochalcone on different experimental models of induced gastric ulcer. Phytother Res 10:616–618

    Article  Google Scholar 

  131. Haniadka R, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS (2013) A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food Funct 4:845–855

    Article  CAS  PubMed  Google Scholar 

  132. Ali BH, Blunden G, Tanira MO, Nemmar A (2008) Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem Toxicol 46:409–420

    Article  CAS  PubMed  Google Scholar 

  133. Chrubasik S, Pittler MH, Roufogalis BD (2005) Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12:684–701

    Article  CAS  PubMed  Google Scholar 

  134. Lohsiriwat S, Rukkiat M, Chaikomin R, Leelakusolvong S (2010) Effect of ginger on lower esophageal sphincter pressure. J Med Assoc Thai 93:366–372

    PubMed  Google Scholar 

  135. Johns Cupp M (2000) Toxicology and clinical pharmacology of herbal products. Humana Press, Totowa

    Book  Google Scholar 

  136. Capasso F, Gaginella TS, Grandolini G, Izzo AA (2003) Phytotherapy. A quick reference to herbal medicine. Springer, Heidelberg

    Google Scholar 

  137. Koh EM, Kim HJ, Kim S et al (2009) Modulation of macrophage functions by compounds isolated from Zingiber officinale. Planta Med 75:148–151

    Article  CAS  PubMed  Google Scholar 

  138. Pongrojpaw D, Somprasit C, Chanthasenanont A (2007) A randomized comparison of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy. J Med Assoc Thail 90:1703–1709

    Google Scholar 

  139. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B (2007) Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thail 90:15–20

    Google Scholar 

  140. Sharma SS, Gupta YK (1998) Reversal of cisplatin-induced delay in gastric emptying in rats by ginger (Zingiber officinale). J Ethnopharmacol 62:49–55

    Article  CAS  PubMed  Google Scholar 

  141. Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, Leeprakobboon K, Leelasettagool C (2006) The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. Am J Obstet Gynecol 194:95–99

    Article  PubMed  Google Scholar 

  142. Phillips S, Ruggier R, Hutchinson SE (1993) Zingiber officinale (ginger)-an antiemetic for day case surgery. Anaesthesia 48:715–717

    Article  CAS  PubMed  Google Scholar 

  143. Mowrey DB, Clayson DE (1982) Motion sickness, ginger, and psychophysics. Lancet 1:655–657

    Article  CAS  PubMed  Google Scholar 

  144. DerMarderosian A, Beutler JA (2006) The review of natural products. Wolters Kluwer, St. Louis

    Google Scholar 

  145. Giacosa A, Morazzoni P, Bombardelli E, Riva A, Bianchi Porro G, Rondanelli M (2015) Can nausea and vomiting be treated with ginger extract? Eur Rev Med Pharmacol Sci 19:1291–1296

    CAS  PubMed  Google Scholar 

  146. Wu KL, Rayner CK, Chuah SK et al (2008) Effects of ginger on gastric emptying and motility in healthy humans. Eur J Gastroenterol Hepatol 20:436–440

    Article  PubMed  Google Scholar 

  147. Hu ML, Rayner CK, Wu KL et al (2011) Effect of ginger on gastric motility and symptoms of functional dyspepsia. World J Gastroenterol 17:105–110

    Article  PubMed  PubMed Central  Google Scholar 

  148. Rani B, Prasad M, Kumar R, Vikram Y, Kachhawa GR, Sharma S (2013) Triphala: a versatile counteractive assortment of ailments. Int J Pharm Chem Sci 2:101–109

    Google Scholar 

  149. Kumar NS, Nair AS, Nair AM, Murali M (2016) Pharmacological and therapeutic effects of Triphala – a literature review. J Pharmacogn Phytochem 23:23–27

    Google Scholar 

  150. Lu K, Chakroborty D, Sarkar C et al (2012) Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-a mediated angiogenesis. PLoS One 7:e43934

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  151. Belapurkar P, Goyal P, Tiwari BP (2014) Immunomodulatory effects of Triphala and its individual constituents: a review. Indian J Pharm Sci 76:467–475

    PubMed  PubMed Central  Google Scholar 

  152. Lee HS, Won NH, Kim KH, Lee H, Jun W, Lee KW (2005) Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro. Biol Pharm Bull 28:1639–1644

    Article  CAS  PubMed  Google Scholar 

  153. Olennikov DN, Kashchenko NI, Chirikova NK (2015) In vitro bioaccessibility, human gut microbiota metabolites and hepatoprotective potential of chebulic ellagitannins: a case of Padma Hepaten® formulation. Nutrients 7:8456–8477

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  154. Biradar YS, Singh R, Sharma K, Dhalwal K, Bodhankar SL, Khandelwal KR (2007) Evaluation of anti-diarrhoeal property and acute toxicity of Triphala Mashi, an Ayurvedic formulation. J Herb Pharmacother 7:203–212

    Article  CAS  PubMed  Google Scholar 

  155. Nariya M, Shukla V, Jain S, Ravishankar B (2009) Comparison of enteroprotective efficacy of Triphala formulations (Indian herbal drug) on methotrexate-induced small intestinal damage in rats. Phytother Res 23:1092–1098

    Article  PubMed  Google Scholar 

  156. Nariya MB, Shukla VJ, Ravishankar B, Jain SM (2011) Comparison of gastroprotective effects of Triphala formulations on stress-induced ulcer in rats. Indian J Pharm Sci 73:682–687

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  157. Pulok K, Mukherjee SR, Bhattacharyya S et al (2005) Clinical study of ‘Triphala’ – a well-known phytomedicine from India. Iran J Pharmacol Ther 5:51–54

    Google Scholar 

  158. Rayudu V, Raju AB (2014) Effect of Triphala on dextran sulphate sodium-induced colitis in rats. Ayu 35:333–338

    Article  PubMed  PubMed Central  Google Scholar 

  159. Carlsen MH, Halvorsen BL, Holte K et al (2010) The total antioxidant content of more than 3100 foods, beverages, spices, herbs and supplements used worldwide. Nutr J 9:1–11

    Article  Google Scholar 

  160. Yadav S, Gite S, Nilegaonkar S, Agte V (2011) Effect of supplementation of micronutrients and phytochemicals to fructooligosaccharides on growth response of probiotics and E. coli. Biofactors 37:58–64

    Article  CAS  PubMed  Google Scholar 

  161. Tabasco R, Sánchez-Patán F, Monagas M et al (2011) Effect of grape polyphenols on lactic acid bacteria and bifidobacteria growth: resistance and metabolism. Food Microbiol 28:1345–1352

    Article  CAS  PubMed  Google Scholar 

  162. Boto-Ordóñez M, Urpi-Sarda M, Queipo-Ortuño MI, Tulipani S, Tinahones FJ, Andres-Lacueva C (2014) High levels of Bifidobacteria are associated with increased levels of anthocyanin microbial metabolites: a randomized clinical trial. Food Funct 5:1932–1938

    Article  PubMed  Google Scholar 

  163. Jimenez N, Esteban-Torres M, Mancheno JM et al (2014) Tannin degradation by a novel tannase enzyme present in some Lactobacillus plantarum strains. Appl Environ Microbiol 80:2991–2997

    Article  PubMed  PubMed Central  Google Scholar 

  164. Matoba Y, Tanaka N, Noda M, Higashikawa F, Kumagai T, Sugiyama M (2013) Crystallographic and mutational analyses of tannase from Lactobacillus plantarum. Proteins 8:2052–2058

    Article  Google Scholar 

  165. Jimenez N, Curiel JA, Reveron I et al (2013) Uncovering the Lactobacillus plantarum WCFS1 gallate decarboxylase involved in tannin degradation. Appl Environ Microbiol 79:4253–4263

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  166. Malfertheiner P (2017) STW 5 (Iberogast) therapy in gastrointestinal functional disorders. Dig Dis:3525–3529

    Google Scholar 

  167. Pilichiewicz AN, Horowitz M, Russo A et al (2007) Effects of Iberogast on proximal gastric volume, antropyloroduodenal motility and gastric emptying in healthy men. Am J Gastroenterol 102:1276–1283

    Article  CAS  PubMed  Google Scholar 

  168. Ammon HP, Kelber O, Okpanyi SN (2006) Spasmolytic and tonic effect of Iberogast (STW 5) in intestinal smooth muscle. Phytomedicine 13:67–74

    Article  PubMed  Google Scholar 

  169. von Arnim U, Peitz U, Vinson B, Gundermann KJ, Malfertheiner P (2007) STW 5, a phytopharmacon for patients with functional dyspepsia: results of a multicenter, placebo-controlled double-blind study. Am J Gastroenterol 102:1268–1275

    Article  Google Scholar 

  170. von Arnim U, Vinson BR, Malfertheiner P et al (2008) Functional dyspepsia: are relapse rates influenced by active treatment. Gastroenterology:134

    Google Scholar 

  171. Madisch A, Holtmann G, Plein K (2004) Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial. Aliment Pharmacol Ther 19:271–279

    Article  CAS  PubMed  Google Scholar 

  172. Kearns GL, Chumpitazi BP, Abdel-Rahman SM, Garg U, Shulman RJ (2015) Systemic exposure to menthol following administration of peppermint oil to pediatric patients. BMJ Open 5:e008375

    Article  PubMed  PubMed Central  Google Scholar 

  173. Haber SL, El-Ibiary SY (2016) Peppermint oil for treatment of irritable bowel syndrome. Am J Health Syst Pharm 73:22–26

    Article  CAS  PubMed  Google Scholar 

  174. Grigoleit HG, Grigoleit P (2005) Pharmacology and preclinical pharmacokinetics of peppermint oil. Phytomedicine 12:612–616

    Article  CAS  PubMed  Google Scholar 

  175. Blumenthal M, Goldberg A, Brinckmann J (2000) Herbal medicine: expanded commission E monographs. Integrative Medicine Communications, Boston

    Google Scholar 

  176. Hawthorn M, Ferrante J, Luchowski E, Rutledge A, Wei XY, Triggle DJ (1988) The actions of peppermint oil and menthol on calcium channel dependent processes in intestinal, neuronal and cardiac preparations. Aliment Pharmacol Ther 2:101–118

    Article  CAS  PubMed  Google Scholar 

  177. Mizuno S, Kato K, Ono Y et al (2006) Oral peppermint oil is a useful antispasmodic for double-contrast barium meal examination. J Gastroenterol Hepatol 21:1297–1301

    Article  PubMed  Google Scholar 

  178. Imagawa A, Hata H, Nakatsu M et al (2012) Peppermint oil solution is useful as an antispasmodic drug for esophagogastroduodenoscopy, especially for elderly patients. Dig Dis Sci 57:2379–2384

    Article  PubMed  Google Scholar 

  179. Cash BD, Epstein MS, Shah SM (2016) A novel delivery system of peppermint oil is an effective therapy for irritable bowel syndrome symptoms. Dig Dis Sci 61:560–571

    Article  CAS  PubMed  Google Scholar 

  180. **ao Y, Li Y, Shu J et al (2019) The efficacy of oral Zhizhu Kuanzhong, a traditional Chinese medicine, in patients with postprandial distress syndrome. J Gastroenterol Hepatol 34:526–531

    Article  CAS  PubMed  Google Scholar 

  181. Wen M, Zhang F, Wang Y (2019) Effect of Zhizhu Kuanzhong capsules on treatment of functional dyspepsia: a meta-analysis of randomized controlled trials. Chin J Integr Med 25:625–630

    Article  PubMed  Google Scholar 

  182. Wei Z, Ai L, Chen X et al (2019) Comparative studies on the regulatory effects of raw and charred hawthorn on functional dyspepsia and intestinal flora. Trop J Pharm Res 18:333–339

    Article  CAS  Google Scholar 

  183. Wu Z, Zhang S, Li P, Lu X, Wang J, Zhao L, Wang Y (2016) Effect of Aurantii Fructus Immaturus Flavonoidon the contraction of isolated gastric smooth muscle strips in rats. Evid Based Complement Alternat Med 2016:1–7

    Google Scholar 

  184. Cremonini F (2014) Standardized herbal treatments on functional bowel disorders: moving from putative mechanisms of action to controlled clinical trials. Neurogastroenterol Motil 26:893–900

    Article  CAS  PubMed  Google Scholar 

  185. Tominaga K, KatoM TH et al (2014) A randomized, placebo-controlled, double-blind clinical trial of rikkunshito for patients with non-erosive reflux disease refractory to proton-pump inhibitor: the G-PRIDE study. J Gastroenterol 49:1392–1405

    Article  CAS  PubMed  Google Scholar 

  186. Kusunoki H, Haruma K, Hata J et al (2010) Efficacy of Rikkunshito, a traditional Japanese medicine (Kampo), in treating functional dyspepsia. Intern Med 49:2195–2202

    Article  PubMed  Google Scholar 

  187. Tominaga K, Kido T, Ochi M et al (2011) The traditional Japanese medicine rikkunshito promotes gastric emptying via the antagonistic action of the 5-HT(3) receptor pathway in rats. Evid Based Complement Alternat Med 2011:248481

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  188. Kitagawa H, Munekage M, Matsumoto T et al (2015) Pharmacokinetic profiles of active ingredients and its metabolites derived from rikkunshito, a ghrelin enhancer, in healthy Japanese volunteers: a cross-over, randomized study. PLoS One 10:e0133159

    Article  PubMed  PubMed Central  Google Scholar 

  189. Kawahara H, Kubota A, Hasegawa T et al (2007) Effects of rikkunshito on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux. Pediatr Surg Int 23:1001–1005

    Article  PubMed  Google Scholar 

  190. Odaka T, Yamato S, Yokosuka O (2017) Esophageal motility and rikkunshito treatment for proton pump inhibitor-refractory non-erosive reflux disease: a prospective, uncontrolled, open-label pilot study trial. Curr Ther Res Clin Exp 84:37–41

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  191. Kito Y, Suzuki H (2010) Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles. Am J Physiol Gastrointest Liver Physiol 298:G755–G763

    Article  CAS  PubMed  Google Scholar 

  192. Hayakawa T, Arakawa T, Kase Y et al (1999) Liu- Jun-Zi-tang, a kampo medicine, promotes adaptive relaxation in isolated Guinea pig stomachs. Drugs Exp Clin Res 25:211–218

    CAS  PubMed  Google Scholar 

  193. Araki Y, Mukaisho KI, Fujiyama Y, Hattori T, Sugihara H (2012) The herbal medicine rikkunshito exhibits strong and differential adsorption properties for bile salts. Exp Ther Med 3:645–649

    Article  PubMed  PubMed Central  Google Scholar 

  194. Shiratori M, Shoji T, Kanazawa M et al (2011) Effect of rikkunshito on gastric sensorimotor function under distention. Neurogastroenterol Motil 23:323–329, 155–156

    Google Scholar 

  195. Tatsuta M, Iishi H (1993) Effect of treatment with liu-jun-zi-tang (TJ-43) on gastric emptying and gastrointestinal symptoms in dyspeptic patients. Aliment Pharmacol Ther 7:459–462

    Article  CAS  PubMed  Google Scholar 

  196. Tominaga K, Iwakiri R, Fujimoto K et al (2012) Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan. J Gastroenterol 47:284–292

    Article  CAS  PubMed  Google Scholar 

  197. Kwon YS, Son M (2013) DA-9701: a new multi-acting drug for the treatment of functional dyspepsia. Biomol Ther 21:181–189

    Article  Google Scholar 

  198. ** M, Son M (2018) DA-9701 (Motilitone): a multi-targeting botanical drug for the treatment of functional dyspepsia. Int J Mol Sci 19:4035

    Article  PubMed  PubMed Central  Google Scholar 

  199. Jung JW, Kim JM, Jeong JS et al (2014) Pharmacokinetics of chlorogenic acid and corydaline in DA-9701, a new botanical gastroprokinetic agent, in rats. Xenobiotica 44:635–643

    Article  CAS  PubMed  Google Scholar 

  200. Choi MG, Rhee PL, Park H et al (2015) Randomized, controlled, multicenter trial: comparing the safety and efficacy of DA-9701 and itopride hydrochloride in patients with functional dyspepsia. J Neurogastroenterol Motil 21:414–422

    Article  PubMed  PubMed Central  Google Scholar 

  201. Park JY, Kim JG, Hong SJ et al (2019) A randomized double-blind comparative study of the efficacy of helicobacter pylori eradication therapy and motilitone® for functional dyspepsia. Korean J Helicobacter Up Gastrointest Res 19:106–114

    Article  Google Scholar 

  202. Park CH, Kim HS, Lee SK (2014) Effects of the new prokinetic agent DA-9701 formulated with corydalis tuber and pharbitis seed in patients with minimal change esophagitis: a bi-center, randomized, double-blind, placebo-controlled study. J Neurogastroenterol Motil 20:338–346

    Article  PubMed  PubMed Central  Google Scholar 

  203. Kim SY, Woo HS, Kim KO et al (2017) DA-9701 improves colonic transit time and symptoms in patients with functional constipation: a prospective study. J Gastroenterol Hepatol 32:1943–1948

    Article  CAS  PubMed  Google Scholar 

  204. Sastry JLN, Vats A, Vedula S, Kumar S (2016) Symptomatic management of functional dyspepsia: evaluation of efficacy and safety of pudin hara pearls and pudin hara liquid. Int J Res Ayurveda Pharm 7:65–69

    Article  CAS  Google Scholar 

  205. Bhardwaj S, Verma R, Gupta J (2018) Challenges and future prospects of herbal medicine. Int Res Med Health Sci 1:12–15

    Google Scholar 

  206. Saggar S, Mir PA, Kumar N, Chawla A, Uppal J, Shilpa, Kaur A (2022) Traditional and herbal medicines: opportunities and challenges. Pharmacogn Res 14:107–114

    Article  CAS  Google Scholar 

  207. Prabhakar P, Mamoni B (2021) Technical problems, regulatory and market challenges in bringing herbal drug into mainstream of modern medicinal practices. Res J Biotechnol 16:3

    Google Scholar 

  208. Lee JY, Jun SA, Hong SS, Ahn YC, Lee DS, Son CG (2016) Systematic review of adverse effects from herbal drugs reported in randomized controlled trials. Phytother Res 30:1412–1419

    Article  PubMed  Google Scholar 

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Acknowledgments

The Chancellor of R G S College of Pharmacy is acknowledged by the writers for his gracious assistance in giving the essential resources and inspiration for the work to be completed successfully.

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Singh, N., Sharma, U., Mishra, B., Kandalkar, A.M., Jain, S.K. (2024). Herbs and Herbal Formulations for the Management and Prevention of Gastrointestinal Diseases. In: Izah, S.C., Ogwu, M.C., Akram, M. (eds) Herbal Medicine Phytochemistry. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-031-43199-9_24

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