Abstract
The influence of unmodified engineered AuNPs versus biofunctionalized by cyanobacterium Arthrospira platensis (spirulina) on rats was studied. Au NPs were administered per os in a quantity of 1 µgAu/day per animal for 28 days, followed by a clearance period of the same duration. The accumulation of nanoparticles in different organs, the change in hematological and biochemical parameters in the experimental animals were assessed at the end of the nanoparticle administration and the clearance periods. The amount of gold accumulated in organs was determined by applying neutron activation analysis at the IBR-2 reactor. Biochemical and hematological analyses of the blood were performed using a semi-automated system StarDust MC15. The biofunctionalized nanoparticles were accumulated in larger amounts, and the amount of metal remaining after the clearance period was also higher in the case of the functionalized nanoparticles. Only biofunctionalized nanoparticles accumulated in the ovaries. Both types of nanoparticles possess high biological activity, inclusive of their induced changes in the leukogram, glucose, urea and liver transaminases levels. More pronounced changes being characteristic for unmodified gold nanoparticles. Tested nanoparticles can cause long-term or delayed effects, which include the increase in glucose and urea levels as well as the increase in ALT activity after the clearance period.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Bansal, S.A., Kumar, V., Karimi, J., Singh, A.P., Kumar, S.: Role of gold nanoparticles in advanced biomedical applications. Nanoscale Adv. 2, 3764–3787 (2020). https://doi.org/10.1039/D0NA00472C
Zhang, S., et al.: Ribbon of DNA lattice on gold nanoparticles for selective drug delivery to cancer cells. Angewandte Chemie Int. Ed. 59, 14584–14592 (2020). https://doi.org/10.1002/anie.202005624
Goddard, Z.R., Marín, M.J., Russell, D.A., Searcey, M.: Active targeting of gold nanoparticles as cancer therapeutics. Chem. Soc. Rev. 49, 8774–8789 (2020). https://doi.org/10.1039/D0CS01121E
Chen, J., et al.: Sex differences in the toxicity of polyethylene glycol-coated gold nanoparticles in mice. Int. J. Nanomedicine 8, 2409–2419 (2013). https://doi.org/10.2147/IJN.S46376
Siddique, S., Chow, J.C.L.: Gold nanoparticles for drug delivery and cancer therapy. Appl. Sci. 10(11), 3824 (2020). https://doi.org/10.3390/app10113824
Khan, H.A., Abdelhalim, M.A.K., Al-Ayed, M.S., Alhomida, A.S.: Effect of gold nanoparticles on glutathione and malondialdehyde levels in liver, lung and heart of rats. Saudi J. Biol. Sci. 19(4), 461–464 (2012). https://doi.org/10.1016/j.sjbs.2012.06.005
Kozics, K., et al.: Pharmacokinetics, biodistribution, and biosafety of PEGylated gold nanoparticles in vivo. Nanomaterials 11(7), 1702 (2021). https://doi.org/10.3390/nano11071702
Rudi, L., et al.: Accumulation and effect of silver nanoparticles functionalized with Spirulina platensis on rats. Nanomaterials 11(11), 2992 (2021). https://doi.org/10.3390/nano11112992
Cepoi, L., et al.: Effects of PEG-coated silver and gold nanoparticles on Spirulina platensis biomass during its growth in a closed system. Coatings 10(8), 717 (2020). https://doi.org/10.3390/coatings10080717
Parveen, A., Malashetty, V.B., Mantripragada, B., Yalagatti, M.S., Abbaraju, V., Deshpande, R.: Bio-functionalized gold nanoparticles: Benign effect in Sprague-Dawley rats by intravenous administration. Saudi J. Biol. Sci. 24(8), 1925–1932 (2017). https://doi.org/10.1016/j.sjbs.2017.11.041
Behroozi, Z., et al.: Distribution of gold nanoparticles into the brain: a systematic review and meta-analysis. Nanotoxicology 15(8), 1059–1072 (2021). https://doi.org/10.1080/17435390.2021.1966116
Hirn, S., et al.: Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration. Eur. J. Pharm. Biopharm. 77(3), 407–416 (2011). https://doi.org/10.1016/j.ejpb.2010.12.029
Bednarski, M., et al.: The influence of the route of administration of gold nanoparticles on their tissue distribution and basic biochemical parameters: in vivo studies. Pharmacol. Rep. 67(3), 405–409 (2015). https://doi.org/10.1016/j.pharep.2014.10.019
Jo, M.R., Bae, S.H., Go, M.R., Kim, H.J., Hwang, Y.G., Choi, S.J.: Toxicity and biokinetics of colloidal gold nanoparticles. Nanomaterials 5(2), 835–850 (2015). https://doi.org/10.3390/nano5020835
Lee, J.H., Gulumian, M., Faustman, E.M., Workman, T., Jeon, K., Yu, I.J.: Blood biochemical and hematological study after subacute intravenous injection of gold and silver nanoparticles and coadministered gold and silver nanoparticles of similar sizes. Biomed. Res. Int. 8460910 (2018). https://doi.org/10.1155/2018/8460910
Acknowledgments
The results were obtained within the project 20.80009.5007.05 funded by the National Agency for Research and Development, Republic of Moldova.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Ethics declarations
The authors declare no conflict of interest.
Rights and permissions
Copyright information
© 2024 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Cepoi, L., Rudi, L., Chiriac, T., Zinicovscaia, I., Grozdov, D., Rudic, V. (2024). Effect of Gold Nanoparticles Functionalized by Arthrospira Platensis on Rats. In: Sontea, V., Tiginyanu, I., Railean, S. (eds) 6th International Conference on Nanotechnologies and Biomedical Engineering. ICNBME 2023. IFMBE Proceedings, vol 91. Springer, Cham. https://doi.org/10.1007/978-3-031-42775-6_40
Download citation
DOI: https://doi.org/10.1007/978-3-031-42775-6_40
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-42774-9
Online ISBN: 978-3-031-42775-6
eBook Packages: EngineeringEngineering (R0)