Abstract
A study is overpowered if there is such a large sample size that small, clinically meaningless differences can be detected statistically. Studies should be planned to detect differences that are clinically meaningful to patients and providers.
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Moore MJ, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25(15):1960–6.
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Cohen, A.L. (2023). Overpowering. In: Problems and Pitfalls in Medical Literature. Springer, Cham. https://doi.org/10.1007/978-3-031-40295-1_17
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DOI: https://doi.org/10.1007/978-3-031-40295-1_17
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